Assistant Project Scientist, Department of Nutrition
- Ph.D., Biochemical Sciences, National Taiwan University, Taiwan
Dr. Hsu's research involves studying the molecular basis of protein tyrosine phosphatases (PTPs) in metabolic regulation. In particular, he uses state-of-the-art genetic (animal models of human disease), biochemical and pharmacological approaches to investigate the role of PTPs in diabetes and its complications.
Ito Y, Hsu MF, Bettaieb A, Koike S, Mello A, Calvo-Rubio M, Villalba J, Haj FG. (2017). Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism, 76:56-69.
Hsu MF, Bettaieb A, Ito Y, Graham J, Havel PJ, Haj FG. (2017). Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Scientific Reports, 7: 461.
Hsu MF, Pan KT, Chang FY, Khoo KH, Urlaub H, Cheng CF, Chang GD, Haj FG, Meng TC. (2016). S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin Signaling. Free Radical Biology and Medicine, 99: 199-213.
Hsu MF, Meng TC. (2010). Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases. Journal of Biological Chemistry, Mar 12;285(11):7919-28.
Hsu MF, Lou YW, Chen YY, Meng TC. (2010). Handbook of Cell Signaling. 2 ed. San Diego: Academic Press, Chapter 105, PTP Oxidation, 855-862p.