Robert M. Hackman, Ph.D.

Robert Hackman

Unit
Research Nutritionist, Department of Nutrition

3150F Meyer Hall
Bio
Education
  • B.A., Natural Sciences, Johns Hopkins University
  • M.S., Biology & Nutrition, Pennsylvania State University
  • Ph.D., Nutrition, University of California, Davis
Research Interests

Dr. Hackman's research addresses the role of foods and nutritional and botanical supplements for enhancement of human health and performance. His current studies explore the role of fruits, nuts, wine and unique botanical extracts on vascular function, inflammation and skin aging.

Selected Publications

Wei, R., Hackman, R.M., Wang, Y., and Mackenzie, G.G. Targeting glycolysis with epigallocatechin-3-gallate enhances the efficacy of chemotherapeutics in pancreatic cancer cells and xenografts. Cancers 11:1496, 2019. [PubMed]

Borkowski, K., Yim, S.J., Holt, R.R., Hackman, R.M., Keen, C.L., Newman, J.W., and Shearer, G.C. Walnuts change lipoprotein composition suppressing TNFa-stimulated cytokine production by diabetic adipocytes. Journal of Nutritional Biochemistry 68:51-8, 2019. [PubMed]

Wei, R., Cortez Penso, N., Hackman, R.M., Wang, Y., and Mackenzie, G. Epigallocatechin-3-Gallate (EGCG) suppresses pancreatic cancer cell growth, invasion and migration partly through the inhibition of Akt pathway and epithelial-mesenchymal transition: Enhanced efficacy when combined with gemcitabine. Nutrients 11:1856, 2019. [PubMed]

Al-Dashti, Y.A., Holt, R.R., Carson, J.G., Keen, C.L., and Hackman, R.M. Effects of short-term dried plum (prune) intake on markers of bone resorption and vascular function in healthy postmenopausal women: A randomized crossover trial. Journal of Medicinal Food 22:982-92, 2019. [PubMed]

Suealek, N., Yokoyama, W.H., Rojpibulstit, P., Holt, R.R., and Hackman, R.M. Thai tea seed (Camellia oleifera) oil favorably affects plasma lipid responses in hamsters fed high-fat diets. European Journal of Lipid Science and Technology 121:1800024, 2019. [Wiley Online Library]

Wei, R., Mao, L., Xu, P., Zheng, X. Hackman, R.M., Mackenzie, G.G. and Wang, Y. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food and Function 14:5682-96, 2018. [PubMed]

Al-Dashti YA, Holt RR, Stebbins CL, Keen CL, Hackman RM. Dietary flavanols: A review of select effects on vascular function, blood pressure, and exercise performance. Journal of the American College of Nutrition 37:1-15, 2018. [PubMed]

Lan, Y., Wu, J., Wang, W., Sun, X., Hackman, R.M., Li, Z., and Feng, X. Evaluation of antioxidant capacity and flavor profile change of pomegranate wine during fermentation and aging process. Food Chemistry 232:777-87, 2017. [PubMed]

Chen, L., Ullah, N., Li, C., Hackman, R.M., Li, Z., Xu, X., Zhou, G., and Feng, X. Incorporated glucosamine adversely affects the emulsifying properties of whey protein isolate polymerized by transglutaminase. Journal of Dairy Science 100:3413-23, 2017. [PubMed]

Djurica, D., Ren, J., Holt, R.R., Feng, X., Carlson, C.R., Shindel, A.W., Keen, C.L, and Hackman, R.M. A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women. PharmaNutrition 4:132-8, 2016.

Chen L, Li C, Ullah N, Guo Y, Sun X, Wang X, Xu X, Hackman RM, Zhou G, Feng X. Different physicochemical, structural and digestibility characteristics of myofibrillar protein from PSE and normal pork before and after oxidation. Meat Science ;121:228-37. 2016. [PubMed]

Djurica D, Holt RR, Ren J, Shindel AW, Hackman RM, Keen CL. Effects of a dietary strawberry powder on parameters of vascular health in adolescent males. British Journal of Nutrition 116:639-47, 2016. [PubMed]

Feng X, Li C, Jia X, Guo Y, Lei N, Hackman RM, Chen L, Zhou G. Influence of sodium nitrite on protein oxidation and nitrosation of sausages subjected to processing and storage. Meat Science 116:260-7, 2016. [PubMed]

Feng, X., Li, C., Ullah, N., Cao, J., Lan, Y., Ge, W., Hackman, R.M., Li, Z., Chen, L. Susceptibility of whey protein isolate to oxidation and changes in physicochemical, structural, and digestibility characteristics. Journal of Dairy Science 98:7602-13, 2015. [PubMed]

Holt RR, Yim SJ, Shearer GC, Hackman RM, Djurica D, Newman JW, Shindel AW, Keen CL. Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content. Journal of Nutritional Biochemistry 26:1458-66, 2015. [PubMed]

Hackman, R.M., Aggarwal, B.B., Applebaum, R.S., deVere White, R.W., Dubick, M.A., Heber, D., Ito, T., Johnson, G.H., Keen, C.L., Winters, B.L., Stohs, S.J. Forecasting nutrition research in 2020. Journal of the American College of  Nutrition 33:340-6, 2014. [PubMed]

deVere White, R. W., Tsodikov, A., Stapp, E. C., Soares, S. E., Fujii, H., and Hackman, R. M. Effects of an aglycone-rich soy extract on serum isoflavone concentrations and prostate specific antigen in men with localized prostate cancer. Nutrition and Cancer 62: 1036-43, 2010. [PubMed]

Kalgaonkar, S., Nishioka, H., Gross, H.B., Fujii H., Keen, C.L., and Hackman, R.M. Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models. Phytotherapy Research 24:1223-8, 2010. [PubMed]

Ray, S.D., Parmar, M., Ismail, S., Rathod, J., Zinkovsky, D., Bulku, E., Gigllioti, J., Hackman, R.M. and Stohs, S.J. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytotherapy Research 22:458-71, 2008. [PubMed]

Polagruto, J.A., Gross, H.B., Kamangar, F., Kosuna, K., Sun, B., Fujii, H., Keen, C.L. and Hackman, R.M. Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. Journal of Medicinal Food 10:725-30, 2007. [PubMed]

Hackman, R.M., Polagruto, J.A., Zhu, Q.Y., Kosuna, K., Sun, B., Fujii, H. and Keen, C.L. Flavanols: Digestion, Absorption and Bioactivity. Phytochemistry Reviews first published online August 29, 2007.

Hackman, R.M., Havel, P.J., Schwartz, H.J., Rutledge, J.C., Watnik, M.R., Noceti, E.M., Stohs, S.J., Stern, J.S., and Keen, C.L. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: A randomized controlled trial. International Journal of Obesity 30:1545-56, 2006. [PubMed]

Ray, S., Patel, C., Phadke, S., Hackman, R.M. and Stohs, S. Short-term or long-term in vivo exposure to an ephedra and caffeine containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Archives of Toxicology 79:330-340, 2005. [PubMed]

deVere White, R.W., Hackman, R.M., Soares, S.E., Beckett, L.A., Li, Y. and Sun, B. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology 63:259-63, 2004. [PubMed]

Schock, B.C., Koostra, J., Kwack, S., Hackman, R.M., van der Vliet, A. and Cross, C.E. Ascorbic acid in nasal and tracheobronchial airway lining fluids. Free Radical Biology and Medicine 37:1393-1401, 2004. [PubMed]

Zhu, Q.Y., Hackman, R.M., Ensunsa, J.L., Holt, R.R. and Keen, C.L. Antioxidative activities of oolong tea. Journal of Agricultural and Food Chemistry 50:6929-34, 2002. [PubMed]

deVere White, R.W., Hackman, R.M., Soares, S.E., Beckett, L.A., and Sun, B. Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology 60:640-4, 2002. [PubMed]

Ji, Q.L., Harkey, M.R., Henderson, G.L., Gershwin, M.E., Stern, J.S. and Hackman, R.M. Quantitative determination of ginsenosides by high performance liquid chromatography-tandem mass spectrometry. Phytochemical Analysis 2001;12:320-6. [PubMed]

Harkey, M.R., Henderson, G.L., Gershwin, M.E., Stern, J.S. and Hackman, R.M. Variability of commercial ginseng products: an analysis of 25 preparations. American Journal of Clinical Nutrition 2001;73:1101-6. [PubMed]

Borchers A.T., Stern, J.S., Hackman, R.M., Keen, C.L., and Gershwin, M.E. Mushrooms, tumors, and immunity. Proceedings of the Society for Experimental Biology and Medicine 1999;221:281-93. [PubMed]

Henderson, G.L., Harkey, M.R., Gershwin, M.E., Hackman, R.M., Stern, J.S., and Stresser, D.M. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sciences 1999;65:209-14. [PubMed]

Borchers, A.T., Van de Water, J., Kenny, T.P., Keen, C.L., Stern, J.S., Hackman, R.M., and Gershwin, M.E. The comparative effects of three species of ginseng on human peripheral blood lymphocyte proliferative responses. International Journal of Immunotherapy 1998;14:143-52.

Borchers, A.T., Hackman, R.M., Keen, C.L., Stern, J.S., and Gershwin, M.E. Complementary medicine: A review of immunomodulatory effects of Chinese herbal medicines. American Journal of Clinical Nutrition 1997;66:1303-12. [PubMed]

Hackman RM, Oman R, Brown RL. Cellular bioenergetics, work performance, body composition and psychological indices among women in a diet-exercise program. Nutrition Research 1995;15:455-465.

Hackman RM, Ellis BK, Brown, RL. Phosphorus magnetic resonance spectra and changes in body composition during weight loss. Journal of the American College of Nutrition 1994;13:243-250. [PubMed]

Hackman RM, Ellis BK Increases in lean body mass and loss of fat mass among moderately obese women in a comprehensive weight management program. International Clinical Nutrition Reviews 1991;11:184-189.

Hackman RM, Wagner EL. The Senior Gardening and Nutrition Project: Development and transport of a dietary behavior change and health promotion program. Journal of Nutrition Education 1990;22: 262-270.