Robert M. Hackman, Ph.D.

Robert Hackman

Research Nutritionist, Department of Nutrition

3150F Meyer Hall
  • B.A., Natural Sciences, Johns Hopkins University
  • M.S., Biology & Nutrition, Pennsylvania State University
  • Ph.D., Nutrition, University of California, Davis
Research Interests

Dr. Hackman's research addresses the role of foods and nutritional and botanical supplements for enhancement of human health and performance. His current studies explore the role of fruits, nuts, wine and unique botanical extracts on vascular function, inflammation and skin aging.

Selected Publications

Al-Dashti YA, Holt RR, Stebbins CL, Keen CL, Hackman RM. Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance. J Am Coll Nutr. 2018 May 2:1-15. [PubMed]

Lan, Y., Wu, J., Wang, W., Sun, X., Hackman, R.M., Li, Z., and Feng, X.  Evaluation of antioxidant capacity and flavor profile change of pomegranate wine during fermentation and aging process.  Food Chemistry 232:777-87, 2017. [PubMed]

Chen, L., Ullah, N., Li, C., Hackman, R.M., Li, Z., Xu, X., Zhou, G., and Feng, X.  Incorporated glucosamine adversely affects the emulsifying properties of whey protein isolate polymerized by transglutaminase.  Journal of Dairy Science 100:3413-23, 2017. [PubMed]

Djurica, D., Ren, J., Holt, R.R., Feng, X., Carlson, C.R., Shindel, A.W., Keen, C.L, and Hackman, R.M.  A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women.  PharmaNutrition 4:132-8, 2016.

Chen L, Li C, Ullah N, Guo Y, Sun X, Wang X, Xu X, Hackman RM, Zhou G, Feng X. Different physicochemical, structural and digestibility characteristics of myofibrillar protein from PSE and normal pork before and after oxidation. Meat Sci. 2016 Nov;121:228-37. [PubMed]

Djurica D, Holt RR, Ren J, Shindel AW, Hackman RM, Keen CL. Effects of a dietary strawberry powder on parameters of vascular health in adolescent males. Br J Nutr. 2016 Aug;116(4):639-47. [PubMed]

Feng X, Li C, Jia X, Guo Y, Lei N, Hackman RM, Chen L, Zhou G. Influence of sodium nitrite on protein oxidation and nitrosation of sausages subjected to processing and storage. Meat Sci. 2016 Jun;116:260-7. [PubMed]

Feng, X., Li, C., Ullah, N., Cao, J., Lan, Y., Ge, W., Hackman, R.M., Li, Z., Chen, L. Susceptibility of whey protein isolate to oxidation and changes in physicochemical, structural, and digestibility characteristics. J Dairy Sci. 2015 Sep 9. pii: S0022-0302(15)00659-1. [PubMed]

Holt RR, Yim SJ, Shearer GC, Hackman RM, Djurica D, Newman JW, Shindel AW, Keen CL. Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content. J Nutr Biochem. 2015 Aug 1. pii: S0955-2863(15)00176-X. doi: 10.1016/j.jnutbio.2015.07.012. [PubMed]

Hackman, R.M., Aggarwal, B.B., Applebaum, R.S., deVere White, R.W., Dubick, M.A., Heber, D., Ito, T., Johnson, G.H., Keen, C.L., Winters, B.L., Stohs, S.J. Forecasting nutrition research in 2020. J Am Coll Nutr. 2014;33(4):340-6. [PubMed]

deVere White, R. W., Hackman, R. M., and Kugelmass, J. The dogmas of nutrition and cancer: Time for a second (and maybe third) look. Annals of the New York Academy of Sciences 1190:118-25, 2010.  [PubMed]

deVere White, R. W., Tsodikov, A., Stapp, E. C., Soares, S. E., Fujii, H., and Hackman, R. M. Effects of an aglycone-rich soy extract on serum isoflavone concentrations and prostate specific antigen in men with localized prostate cancer. Nutrition and Cancer 62: 1036-43, 2010. [PubMed]

Kalgaonkar, S., Nishioka, H., Gross, H.B., Fujii H., Keen, C.L., and Hackman, R.M. Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models. Phytotherapy Research 24:1223-8, 2010. [PubMed]

Hackman, R.M., Kalgaonkar, S., Gross, H.B., Keen, C.L., Fujii, H and Dubick, M.A. Absorption of flavanols from a novel lychee fruit extract rich in flavonoids, and effects on membrane stability and oxidant defense in experimental animals and healthy human adults. Polyphenol Communications 2:837-8, 2008.

Ray, S.D., Parmar, M., Ismail, S., Rathod, J., Zinkovsky, D., Bulku, E., Gigllioti, J., Hackman, R.M. and Stohs, S.J. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytotherapy Research 22:458-71, 2008. [PubMed]

Hackman, R.M., Polagruto, J.A., Zhu, Q.Y., Kosuna, K., Sun, B., Fujii, H. and Keen, C.L. Flavanols: Digestion, Absorption and Bioactivity. Phytochemistry Reviews 7:195-208, 2008.

Polagruto, J.A., Gross, H.B., Kamangar, F., Kosuna, K., Sun, B., Fujii, H., Keen, C.L. and Hackman, R.M. Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. Journal of Medicinal Food 10:725-30, 2007. [PubMed]

Hackman, R.M., Polagruto, J.A., Zhu, Q.Y., Kosuna, K., Sun, B., Fujii, H. and Keen, C.L. Flavanols: Digestion, Absorption and Bioactivity. Phytochemistry Reviews first published online August 29, 2007.

Hackman, R.M., Havel, P.J., Schwartz, H.J., Rutledge, J.C., Watnik, M.R., Noceti, E.M., Stohs, S.J., Stern, J.S., and Keen, C.L. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: A randomized controlled trial. International Journal of Obesity 30:1545-56, 2006. [PubMed]

Ray, S., Patel, C., Phadke, S., Hackman, R.M. and Stohs, S. Short-term or long-term in vivo exposure to an ephedra and caffeine containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Archives of Toxicology 79:330-340, 2005. [PubMed]

deVere White, R.W., Hackman, R.M., Soares, S.E., Beckett, L.A., Li, Y. and Sun, B. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology 63:259-63, 2004. [PubMed]

Schock, B.C., Koostra, J., Kwack, S., Hackman, R.M., van der Vliet, A. and Cross, C.E. Ascorbic acid in nasal and tracheobronchial airway lining fluids. Free Radical Biology and Medicine 37:1393-1401, 2004. [PubMed]

Zhu, Q.Y., Hackman, R.M., Ensunsa, J.L., Holt, R.R. and Keen, C.L. Antioxidative activities of oolong tea. Journal of Agricultural and Food Chemistry 50:6929-34, 2002. [PubMed]

deVere White, R.W., Hackman, R.M., Soares, S.E., Beckett, L.A., and Sun, B. Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology 60:640-4, 2002. [PubMed]

Ji, Q.L., Harkey, M.R., Henderson, G.L., Gershwin, M.E., Stern, J.S. and Hackman, R.M. Quantitative determination of ginsenosides by high performance liquid chromatography-tandem mass spectrometry. Phytochemical Analysis 2001;12:320-6. [PubMed]

Harkey, M.R., Henderson, G.L., Gershwin, M.E., Stern, J.S. and Hackman, R.M. Variability of commercial ginseng products: an analysis of 25 preparations. American Journal of Clinical Nutrition 2001;73:1101-6. [PubMed]

Hackman, R.M., Stern, J.S., and Gershwin, M.E. Hypnosis and asthma: A critical review. Journal of Asthma 2000;37:1-15. [PubMed]

Hackman, R.M., Stern, J.S., and Gershwin, M.E. Complementary/alternative therapies in general medicine: Asthma and allergies. In: Complementary/Alternative Medicine: An Evidence-Based Approach, J.W. Spencer and J.J. Jacobs (Eds.). Mosby Year Book, St. Louis, Chapter 3, pp. 65-89, 1999.

Borchers A.T., Stern, J.S., Hackman, R.M., Keen, C.L., and Gershwin, M.E. Mushrooms, tumors, and immunity. Proceedings of the Society for Experimental Biology and Medicine 1999;221:281-93. [PubMed]

Henderson, G.L., Harkey, M.R., Gershwin, M.E., Hackman, R.M., Stern, J.S., and Stresser, D.M. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sciences 1999;65:209-14. [PubMed]

Borchers, A.T., Van de Water, J., Kenny, T.P., Keen, C.L., Stern, J.S., Hackman, R.M., and Gershwin, M.E. The comparative effects of three species of ginseng on human peripheral blood lymphocyte proliferative responses. International Journal of Immunotherapy 1998;14:143-52.

Davis, P.A., Chang, C., Hackman, R.M., Stern, J.S., and Gershwin, M.E. Acupuncture in the treatment of asthma: A critical review. Allergology and Immunopathology 1998;26:263-71. [PubMed]

Davis, P.A., Gold, E.B., Hackman, R.M., Stern, J.S. and Gershwin, M.E. The use of complementary/alternative medicine for the treatment of asthma in the United States. Investigative Allergology and Clinical Immunology 1998;8:73-77. [PubMed]

Borchers, A.T., Hackman, R.M., Keen, C.L., Stern, J.S., and Gershwin, M.E. Complementary medicine: A review of immunomodulatory effects of Chinese herbal medicines. American Journal of Clinical Nutrition 1997;66:1303-12. [PubMed]

Hackman, R.M., Stern, J.S., and Gershwin, M.E. Complementary and alternative medicine and asthma. Clinical Reviews in Allergy and Immunology 1996;14:321-37. [PubMed]

Hackman RM, Oman R, Brown RL. Cellular bioenergetics, work performance, body composition and psychological indices among women in a diet-exercise program. Nutrition Research 1995;15:455-465.

Hackman RM, Ellis BK, Brown, RL. Phosphorus magnetic resonance spectra and changes in body composition during weight loss. Journal of the American College of Nutrition 1994;13:243-250. [PubMed]

Hackman RM, Katra J, Geertsen S. The athletic trainer's role in modifying nutritional behaviors of adolescent athletes: Putting theory into practice. Journal of Athletic Training 1992;27:262-267. [PubMed]

Hackman RM, Ellis BK Increases in lean body mass and loss of fat mass among moderately obese women in a comprehensive weight management program. International Clinical Nutrition Reviews 1991;11:184-189.

Hackman RM. Nutrition and sports performance for the older athlete. In: Sports Science Symposium: Proceedings from the VIIIth World Veterans' championships. E. Zemper, G. Steigelman and S. James (Eds.) International Institute for Sports and Human Performance, Eugene, pp. 77-85, 1991.

Hackman RM, Wagner EL. The Senior Gardening and Nutrition Project: Development and transport of a dietary behavior change and health promotion program. Journal of Nutrition Education 1990;22: 262-270.