John W. Newman, Ph.D.

Education

• B.A, Biochemistry & Molecular Biology, University of California, Santa Cruz
• Ph.D., Pharmacology & Toxicology, University of California, Davis

Research Interests

Dr. Newman's research group is developing and applying targeted and untargeted metabolomics tools to investigate metabolic responses to diet and their implications in the context of obesity and its associated co-morbidities. Active research areas include: 1) Investigating the functional implications of lipoprotein particle metabolomics structure on vascular and adipose physiology; 2) Investigating cross-talk between mediators of energy metabolism, inflammation, tissue growth and satiety; 3) Mapping the natural variance in metabolic responses to dietary challenges; 4) Investigating the impact of diet quality and weight maintenance/loss on metabolic indices of health.

Selected Publications

Shearer, G.C., K. Borkowski, S.L. Puumala, W.S. Harris, T.L. Pedersen, J.W. Newman. 2017. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. Prostag Leukotr Ess. Fatty Acids. 128. 1-10. [PubMed]

Hernandez-Carretero, A., N. Weber, M.R. LaFrano, J. Lantero Rodriguez, D.D. Sears, V. Wallenius, E. Börgeson, J.W. Newman, O. Osborn. 2017. Obesity-induced changes in lipid mediators persist after weight loss. Int. J. Obes. 1-9. [PubMed]

Agrawal, K., E. Melliou, X. Li, T.L. Pedersen, S.C. Wang, P. Magiatis, J.W. Newman, R.R. Holt. 2017. Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial. J. Func. Foods. 36:84-93. [PubMed]

Beccarelli LM, Scherr RE, Newman JW, Borkowska AG, Gray IJ, Linnell JD, Keen CL, Young HM. Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children. J Am Coll Nutr. 2018 Jan;37(1):44-50. [PubMed]

Tepaamorndech S, Kirschke CP, Pedersen TL, Keyes WR, Newman JW, Huang L. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activation and glucose uptake. FEBS J. 2015 Nov 2. doi: 10.1111/febs.13582.   [PubMed]

Picklo MJ Sr, Newman JW. Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats. Free Radic Biol Med. 2015 Sep 28;89:182-191. [PubMed]

Holt RR, Yim SJ, Shearer GC, Hackman RM, Djurica D, Newman JW, Shindel AW, Keen CL. Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content. J Nutr Biochem. 2015 Aug 1. pii: S0955-2863(15)00176-X. doi: 10.1016/j.jnutbio.2015.07.012. [PubMed]

Piccolo BD, Keim NL, Fiehn O, Adams SH, Van Loan MD, Newman JW. Habitual Physical Activity and Plasma Metabolomic Patterns Distinguish Individuals with Low vs. High Weight Loss during Controlled Energy Restriction. J Nutr. 2015 Apr;145(4):681-90. [PubMed]

Midtbø LK, Borkowska AG, Bernhard A, Rønnevik AK, Lock EJ, Fitzgerald ML, Torstensen BE, Liaset B, Brattelid T, Pedersen TL, Newman JW, Kristiansen K, Madsen L. Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. J Nutr Biochem. 2015 Feb 4. pii: S0955-2863(15)00021-2.[PubMed]

Snowden SG, Grapov D, Settergren M, D'Alexandri FL, Haeggström JZ, Fiehn O, Hyötyläinen T, Pedersen TL, Newman JW, Orešič M, Pernow J, Wheelock CE. High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Circ Cardiovasc Genet. 2014 Dec;7(6):955-64. [PubMed]

Newman JW, Pedersen TL, Brandenburg VR, Harris WS, Shearer GC. Effect of omega-3 fatty acid ethyl esters on the oxylipin composition of lipoproteins in hypertriglyceridemic, statin-treated subjects. PLoS One. 2014 Nov 13;9(11):e111471. [PubMed]

Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20;23(25):6838-47. [PubMed]

La Merrill M, Karey E, Moshier E, Lindtner C, La Frano MR, Newman JW, Buettner C. Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLoS One. 2014 Jul 30;9(7):e103337. [PubMed]

Dunn TN, Keenan AH, Thomas AP, Newman JW, Adams SH. A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice. Nutr Metab (Lond). 2014 May 30;11:24. [PubMed]

Fjære E, Aune UL, Røen K, Keenan AH, Ma T, Borkowski K, Kristensen DM, Novotny GW, Mandrup-Poulsen T, Hudson BD, Milligan G, Xi Y, Newman JW, Haj FG, Liaset B, Kristiansen K, Madsen L. Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. J Biol Chem. 2014 Jun 6;289(23):16032-45. [PubMed]

Gladine C, Newman JW, Durand T, Pedersen TL, Galano JM, Demougeot C, Berdeaux O, Pujos-Guillot E, Mazur A, Comte B. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. PLoS One. 2014 Feb 18;9(2):e89393. [PubMed]

Campbell C, Grapov D, Fiehn O, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Gustafson MB, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, Hoppel CL, Meissen JK, Take K, Adams SH. Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One. 2014 Jan 8;9(1):e84260. [PubMed]

O'Sullivan A, Armstrong P, Schuster GU, Pedersen TL, Allayee H, Stephensen CB, Newman JW. Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. J Nutr. 2014 Feb;144(2):123-31. [PubMed]

Pedersen LR, Olsen RH, Frederiksen M, Astrup A, Chabanova E, Hasbak P, Holst JJ, Kjær A, Newman JW, Walzem R, Wisløff U, Sajadieh A, Haugaard SB, Prescott E. Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol. BMC Cardiovasc Disord. 2013 Nov 19;13:106. [PubMed]

Schuster GU, Bratt JM, Jiang X, Pedersen TL, Grapov D, Adkins Y, Kelley DS, Newman JW, Kenyon NJ, Stephensen CB. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. Am J Respir Cell Mol Biol. 2014 Mar;50(3):626-36. [PubMed]

Piccolo BD, Dolnikowski G, Seyoum E, Thomas AP, Gertz ER, Souza EC, Woodhouse LR, Newman JW, Keim NL, Adams SH, Van Loan MD. Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults. Nutrients. 2013 Aug 26;5(9):3352-66. [PubMed]

Schie IW, Nolte L, Pedersen TL, Smith Z, Wu J, Yahiatène I, Newman JW, Huser T. Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by comparative Raman spectroscopy and gas chromatography. Analyst. 2013 Nov 7;138(21):6662-70. [PubMed]

Bruins, M.J., A.D. Dane, K. Strassburg, R.J. Vreeken, J.W. Newman, N. Salem Jr., C. Tyburczy, J.T. Brenna.  Plasma Oxylipin Profiling Identifies Polyunsaturated Vicinal Diols as Responsive to Arachidonic Acid and Docosahexaenoic Acid Intake in Growing Piglets. J Lipid Res. 2013 Mar 29. [Epub] PMID: 23543770. [PubMed]

Zunino, S.J., D.H. Storms, J.W. Newman, T.L. Pedersen, C.L. Keen, J.M. Ducore. Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. 2013. Int. J. Oncol. 42:741-8. [PubMed]

Fedor, D.M, Y. Adkins, J.W. Newman, B.E. Mackey, D.S. Kelley. 2013. The Effect of Docosahexaenoic Acid on t10, c12-Conjugated Linoleic Acid-Induced Changes in Fatty Acid Composition of Mouse Liver, Adipose and Muscle. Metab Syndr Relat Disord. 11(1):63-70. doi: 10.1089/met.2012.0116. [Epub 2012 Nov 21]. [PubMed]

Grapov D., S.H. Adams, T.L. Pedersen, W.T. Garvey, J.W. Newman. 2012. Type 2 diabetes associated changes in circulating non-esterified fatty acids, oxylipins, and endocannabinoids. PLoS ONE. 7(11): e48852. doi:10.1371/journal.pone. 0048852. [PubMed]

Zunino, S.J., D.H. Storms, J.W. Newman, T.L. Pedersen, C.L. Keen, J.M. Ducore. 2012. Dietary resveratrol does not delay engraftment, sensitize to vincristine, or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice. Int. J. Oncol. 41:2207. [Epub: Oct. 4, 2012]. Sept 11, 2012. doi: 10.3892/ijo.2012.1650. [PubMed]

Jamil K.M., K.H. Brown, M. Jamil, J.M. Peerson, A.H. Keenan, J.W. Newman, M.J. Haskell.  2012. Daily consumption of orange-fleshed sweet potato for 60-d increased plasma β-carotene concentration, but did not increase total body vitamin A pool size in Bangladeshi women.  J. Nutr. 142(10):1896-902. [Epub: Aug 29, 2012]. PMID: 22933750.

Sun C., K. Alkhoury, Y.I. Wang, G.A. Foster, C.E. Radecke, K. Tam, C.M. Edwards, M.T. Facciotti, E.J. Armstrong, A.A. Knowlton, J.W. Newman, A.G. Passerini, S.I. Simon. 2012. IRF-1 and miRNA126 modulate inflammatory VCAM-1 expression in response to a high fat meal. Circ. Res. 111(8):1054-64. [Epub: Aug 8, 2012]. PMID: 22874466. [PubMed]

Shahab-Ferdows S., M.A. Anaya-Loyola, H.V. Castañeda, J.L. Rosado, W.R. Keyes, J.W. Newman, J.W. Miller, L.H. Allen. 2012. Vitamin B-12 supplementation of rural mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker. J. Nutr. 142:1881-7. [Epub: Aug 22, 2012] PMID: 22915298. doi: 10.3945/​jn.112.165712. [PubMed]

Huang S., J.M. Rutkowsky, R.G. Snodgrass, K. Ono-Moore, J.W. Newman, D.A. Schneider, D.H. Hwang. 2012. Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways.  J. Lipid Res.  53(9):2002-13. [Epub: Jul 4, 2012]. PMID: 22766885. [PubMed]

D. Grapov, D., J.W. Newman. 2012. imDEV: a Graphical User Interface to R Multivariate Analysis Tools in Microsoft Excel. Bioinformatics. 28(17):2288-90. [Epub: Jul 19, 2012]. doi: 10.1093/bioinformatics/bts439. PMID: 22815358. [PubMed]

Strassburg, K., A.M.L. Huijbrechts, K. Kortekaas, J. Lindeman, T.L. Pedersen, A. Dane,  R. Berger, A. Brenkman, T. Hankemeier, J. van Duynhoven, E. Kalkhoven, J.W. Newman, R. Vreeken. 2012. Quantitative Profiling of Oxylipins through Comprehensive LC-MS/MS Analysis: Application in cardiac surgery.  Anal. Bianal. Chem. 404(5):1413-26 [Epub: Jul 20, 2012]. PMID: 22814969. [PubMed]

Keenan, A.H., T.L. Pedersen, K. Fillaus, G.C. Shearer, J.W. Newman. 2012. Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers. J. Lipid Res. 53:1662-1669. PMID: 22628615. doi: 10.1194/jlr.P025577. [PubMed]

Armstrong, P., D.S. Kelley, J.W. Newman, F. Staggers Sr.,  J. Hartiala, H. Allayee, C.B. Stephensen.  2012. Arachidonate 5-Lipoxygenase Gene Variants Affect Response to Fish Oil Supplementation by Healthy African Americans. J. Nutr. 142(8):1417-28. Epub 2012 Jun 27. PMID: 22739369. [PubMed]

Krishnan, S., J.W. Newman, T.A. Hembrooke, N.L Keim. 2012. Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful? Nutr. Metab. (Lond). 9(1):26. doi:10.1186/1743-7075-9-26. [PubMed]

Zunino, S.J., D.H. Storms, J.W. Newman, T.L. Pedersen, C.L. Keen, J.M. Ducore. 2011. Resveratrol given intraperitoneally does not inhibit growth of high-risk t(4;11) acute lymphoblastic leukemia cells in NOD/SCID mouse model.  Int. J. Oncol. 40(4):1277-84. [Epub Dec 22, 2011]. PMID: 22200740. doi: 10.3892/ijo.2011.1316. [PubMed]

Giordano R.M., J.W. Newman, T.L. Pedersen, M. Ramos, C. Stebbins. 2011. Effects of dynamic exercise on arachidonic acid metabolism.  Int. J. Sport Nutr. Exerc. Metabol. 21, 471-479. PMID: 22089302. [PubMed]

Bendsen, N.T.,  S. Stender, P.B. Szecsi, S.B. Pedersen, S. Basu, L.I. Hellgren, J.W. Newman, T.M. Larsen, S.B. Haugaard,  A. Astrup. 2011. Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. J. Lipid Res. 52: 1821-1828. PMID: 21795740. [PubMed]

Pedersen, T.L., W.R. Keyes, S. Shahab-Ferdows, L.H. Allen, J.W. Newman.  2011. Methylmalonic Acid Quantification in Low Serum Volumes Using UPLC-MS/MS.  J. Chromatogr. B. 879, 1502-6. doi: 10.1016/j.jchromb.2011.03.039 [PubMed]

Psychogios, N., D.D. Hau, J. Peng, A.C. Guo, R. Mandal, S. Bouatra, I. Sinelnikov, R. Krishnamurthy, R. Eisner, B. Gautam, N. Young, J. Xia, C. Knox, E. Dong, P. Huang, Z. Hollander, T.L. Pedersen, S.R. Smith, F. Bamforth, R. Greiner, B. McManus, J.W. Newman, T. Goodfriend, D.S. Wishart. 2011. The human serum metabolome.  PloS One. 6(2):e16857. PMID: 21359215.

Stephensen, C.B., P. Armstrong, J.W. Newman, T.L. Pedersen, J. Legault, G. Schuster, D. Kelley, S. Vikman, R. Nesser, M.F. Seldin, J. Hartiala, H. Allayee.  2011. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J. Lipid Res. 52(5):991-1003. [Epub Feb 4.] [PubMed]

Hartiala, J., D. Li, D.V. Conti, S. Vikman, Y. Patel, W.H.W. Tang, M-L. Brennan, J.W. Newman, C.B. Stephensen, P. Armstrong, S.L. Hazen, H. Allayee.  2011. Genetic contribution of the leukotriene pathway to coronary artery disease.   Hum. Genet. 129(6):617-27. doi: 10.1007/s00439-011-0963-3 [PubMed]

Gertow, K., E. Nobili, L. Folkersen, J.W. Newman, T.L. Pedersen, J. Ekstrand, J. Swedenborg, H. Kühn, C.E. Wheelock, G.K. Hansson, U. Hedin, J.Z. Haeggström, A. Gabrielsen.  2011. 12- and 15-lipoxygenase in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.  Atherosclerosis. 215(2): 411-16. [Epub: Feb 2011]. doi:10.1016/j.atherosclerosis.2011.01.015 [PubMed]

Bendsen, N.T.,  E. Chabanova, H.S. Thomsen, T.M. Larsen, J.W. Newman, S. Stender, J. Dyerberg, S.B. Haugaard,  A. Astrup. 2011. Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women. Nutr. Diab. 1: e4. doi:10.1038/nutd.2010.4 [PubMed]

Fiehn O., W.T. Garvey, J.W. Newman, K.H. Lok, C.L. Hoppel, S.H. Adams. 2010. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS One.  5(12):e15234.  PMID: 21170321. [PubMed]

Stumbo, P.J., R. Weiss, J.W. Newman, J.A. Pennington. K.L. Tucker, P.L. Wiesenfield, A-K. Illner, D.M. Klurfeld, J. Kaput. 2010. Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical activity for personalized health research.  J. Nutr. 140(12):2104-15. [E pub. Oct 27,2010]. doi: 10.3945/jn.110.128371. [PubMed]

Van Erk, M.J., S. Wopereis, C. Rubingh, T. van Vliet, E. Verheij, N.H.P. Cnubben, T. L. Pedersen, J.W. Newman, A.K.Smilde, J. van der Greef, H.F.J. Hendriks, B. van Ommen. 2010. Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. BMC Medical Genomics. 3(5). [PubMed]

Shearer, G.C., W.S. Harris, T.L. Pedersen, J.W. Newman. 2010. Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters.  J. Lipid Res. 51(8): 2074-81. [Epub Aug, 2009]. [PubMed]

Shearer, G.C., J.W. Newman. 2009. Impact of circulating esterified eicosanoids and other oxylipins on endothelial function. Curr. Atheroscler. Rep. 11(6):403-10. [PubMed]

Adams, S.H., C.L. Hoppel, K. Lok, L. Zhao, S. Wong, P.E. Minkler, D.H. Hwang, J.W Newman, W.T. Garvey. 2009. Plasma acylcarnitine profiles suggest incomplete fatty acid β-oxidation and altered TCA cycle activity in type 2 diabetes. J. Nutr. 139(6):1073-81. [PubMed]

Paulino, G., C.B. de la Serre, T. Knotts, P. Oort, J.W. Newman, S. Adams, H. Raybould. 2009. Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. Am J Physiol Endocrinol Metab 296:898-903. Epub Feb 3, 2009. [PubMed]

Shearer, G.C, J.W. Newman. 2008. Lipoprotein lipase liberates esterified oxylipins from very low-density lipoproteins. Prostaglandins Leukot. Essent. Fatty Acids. 79(6):215–22. [PubMed]

Wang, L., R. Gill, T.L. Pedersen, J.W. Newman, J.C. Rutledge. 2009. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that induce endothelial cell inflammation.  J. Lipid Res. 50(2):204-13 [Epub Sept, 2008]. [PubMed]

Sanchez-Mejia, R.S., J.W. Newman, S. Toh, G-Q. Yu, Y. Zhou, K. Scearce-Levie, I.H. Cheng, L. Gan, J.J. Palop, J.V. Bonventre, L. Mucke.  2008. Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer’s disease. Nat Neurosci. 11(11):1311-8 * [PubMed]

Kim, S.I., C.B. Andaya, J.W. Newman, S.S. Goyal, T.H. Tai.  2008. Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize MIK.  Theor. Appl. Genet. 117(8):1291-301. [PubMed]

Athirakul, K., J. A. Bradbury, J.P. Graves, L.M. DeGraff, J. Ma, Y. Zhao, J.F. Couse, R. Quigley, D.R. Harder, X. Zhao, J.D. Imig, T.L. Pedersen, J.W. Newman, B.D. Hammock, A.J. Conley, K.S. Korach, T.M. Coffman, D.C. Zeldin.  2008. Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB. 22(12):4096-108 [Epub. Aug 2008]. [PubMed]

Olearczyk, J.J., J.E. Quigley, B.C. Mitchell, T. Yamamoto, I-H. Kim, J.W. Newman, A. Luria, B.D. Hammock, J.D. Imig. 2009. Administration of a substituted adamantly-urea inhibitor of the soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clin. Sci. (Lond). 116:61-70 [Epub May 7, 2008]. [PubMed]

Morisseau, C., J.W. Newman, C.E. Wheelock, T. Hill, D. Morin, A.R. Buckpitt, B.D. Hammock.  2008. Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase. Chem. Res. Toxicol. 21(4):951-7. [PubMed]

Driesbach, A., J.C. Rice, S. Japa, J.W. Newman, A. Sigel, R.S. Gill, A.E. Hess, B.D. Hammock, J.J.L. Lertora, L.L. Hamm. 2008. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects.  Hypertension. 51:755-61. [PubMed]

Wheelock, C.E., J. Forshed, S. Goto, B.D. Hammock, J.W. Newman. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem. Res. Toxicol. 21(3):583-90. [PubMed]

Vogel, C.F.A., W. Li, J.W. Newman, B.D. Hammock, J. Tuscano, F. Matsumura. 2007.  Pathogenesis of Ah-Receptor mediated development of lymphoma is associated with increased Cyclooxygense-2 expression.  Am J Pathol. 171(5):1538-48. [PubMed]

Newman, J.W., B.D. Hammock, G.A. Kaysen, G.C. Shearer. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J. Lipid Res. 48(8):1792-800. [PubMed]

Wheelock, C.E., S. Goto, B.D. Hammock, J.W. Newman. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics. 3(2):137-45. [PubMed]

Luria, A., S.M. Weldon, A.K. Kabcenell, R.H. Ingraham, D. Matera, R. Gill, C. Morisseau, J.W. Newman , B.D. Hammock. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice. J Biol Chem. 282(5):2891-8 [PubMed]

Morisseau, C., J.W. Newman, H.-J. Tsai, P.A. Beacker, B.D. Hammock.  2006. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 16:5439-44. [PubMed]

Seubert, J.M., C.J. Sinal, J.P. Graves, L.M. DeGraff, C.R. Lee, K.B. Goralski, M.A. Carey, A.H. Luria, J.W. Newman, B.D. Hammock, H. Roberts, H.A. Rockman, E. Murphy, D.C. Zeldin.  2006. Role of soluble epoxide hydrolase in post-ischemic recovery of heart contractile function. Circ Res. 99(4):442-50. [PubMed]

Lee, C.R.  K.E. North, M.S. Bray, M. Fornage, J.M. Seubert, J.W. Newman, B.D. Hammock, D.J. Couper, G. Heiss, D.C. Zeldin. 2006. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: an Atherosclerosis Risk in Communities (ARIC) study. Human Molec Genetics. 15(10):1640-9. [PubMed]

Kelley, D.S., G.L. Bartolini, J.W. Newman, M. Vemuri, B.E. Mackey. 2006. Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10,c12-, and c9,t11-conjugated linoleic acid. Prostaglandins Leukot Essent Fatty Acids. 74(5):331-8. *+ [PubMed]

Davis, B.B., C. Morisseau, T. Pedersen, J.W. Newman, B.D. Hammock, R.H. Weiss. 2006. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther. 316(2):815-21. [PubMed]

Dorrance, A.M., N. Rupp, D.M. Pollock, J.W. Newman, B.D. Hammock, J.D. Imig. 2005. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido) dodecanoic Acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol. 46(6):842-6. [PubMed]

Imig, JD., X. Zhao, C.Z. Zaharis, J.J. Olearczyk, D.M. Pollock, J.W. Newman, I-H. Kim, T. Watanabe, B.D. Hammock. 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 46(4): 975-81. [PubMed]

Tran, K.L., P.A. Aronov, H. Tanaka, J.W. Newman, B.D. Hammock, C. Morisseau. 2005. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase.  Biochemistry. 44(36): 12179-87. [PubMed]

Schmelzer, K., L. Kubala, J. Eiserich, J.W. Newman, B.D. Hammock. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Nat Acad Sci USA. 102(28):9772-77. *+ [PubMed]

Shearer, G.C., J.W. Newman, B.D. Hammock, G.A. Kaysen. 2005. The graded effects of proteinuria on HDL structure in nephrotic rats. J Am Soc Nephrol. 16:1309-19. *+ [PubMed]

Newman, J.W., C. Morisseau, B.D. Hammock. 2005. Epoxide hydrolases: Their role and interactions with lipid metabolism. Prog Lipid Res. 44:1-51. [PubMed]

Newman J.W., Stok J.E., Vidal J.D., Corbin C.J., Huang Q., Hammock B.D., Conley AJ. 2004. Cytochrome p450-dependent lipid metabolism in preovulatory follicles. Endocrinology 145:5097-105. [PubMed]

Seubert, J., B. Yang, A. Bradbury, J. Graves, L. Miller, S. Gabel, R. Gooch, J. Foley, J. Newman, L. Mao, H.A. Rockman, B.D. Hammock, E. Murphy, D.C. Zeldin. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res 95:506-14. [PubMed]

Dey, A., R.S. Williams, D.M. Pollock, D.W. Stepp, J.W. Newman, B.D. Hammock, J.D. Imig. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12:1278-89. [PubMed]

Zhao, X., T. Yammamoto, J.W. Newman, I-H. Kim, T. Watanabe, B.D. Hammock, J. Stewart, J.S. Pollock, D.M. Pollock, J.D. Imig. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J Am Soc Nephrol. 15:1244-53. [PubMed]

DuTeaux, S.B., J.W. Newman, C. Morisseau, E.A. Fairbairn, K. Jelks, B.D. Hammock, M.G. Miller.  2004. Epoxide hydrolases in the rat epididymis: Possible roles in xenobiotic metabolism and endogenous fatty acid metabolism. Toxicol Sci. 78: 187-95. [PubMed]

Sather, P.J., J.W. Newman, M.G. Ikonomou. 2003. Congener based Aroclor quantification and speciation techniques – A comparison of the strengths, weaknesses, and proper use of two alternative approaches. Environ Toxicol Chem.  37: 5678-86. [PubMed]

Viswanathan, S., B.D. Hammock, J.W. Newman, P. Meerarani, M. Toborek, B.Hennig. 2003. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J Am Coll Nutr. 22(6):502-10. [PubMed]

Koivunen, M.E., C. Morisseau, J.W. Newman, W.R. Horwath, B.D. Hammock. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol Biochem. 35: 1433-42.

Watanabe, T., C. Morisseau, J.W. Newman, B.D. Hammock. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos. 31(7): 846-53. [PubMed]

Newman, J.W., C. Morisseau, T.R. Harris, B.D. Hammock. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Nat Acad Sci USA. 100(4):1558-63. [PubMed]

Newman, J.W., T. Watanabe, B.D. Hammock. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res. 43(9):1563-78. [PubMed]

Wheelock, C.E., T.A. Baumgartner, J.W. Newman, M.F. Wolfe, R.S. Tjeerdema. 2002. Effect of nutritional state on Hsp60 levels in the rotifer Brachionus plicatilis following toxicant exposure. Aquatic Toxicol. 61(1-2):89-93. [PubMed]

Morisseau, C., M.H. Goodrow, J.W. Newman, C.E. Wheelock, D.L. Dowdy, B.D. Hammock. 2002. Structural refinement of urea based soluble epoxide hydrolase inhibitors. Biochem Pharmacol. 63(9):1599-1608. [PubMed]

Watkins, S.M., B.D. Hammock, J.W. Newman, J.B. German. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am J Clin Nutr. 74(3):283-6. [PubMed]

Newman, J.W., and B.D. Hammock. 2001 Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J Chromatogr A. 925(1-2):223-40. [PubMed]

Hunt, J.W., B.S. Anderson, B.M. Phillips, J. Newman, R.S. Tjeerdema, R. Fairey, H.M. Puckett, M. Stephenson, R.W. Smith, C.J. Wilson, and K.M. Taberski.  2001. Evaluation and use of sediment toxicity reference sites for statistical comparisons in regional assessments. Environ Toxicol Chem. 20(6):1266-75. [PubMed]

Morisseau, C., J.W. Newman, D.L. Dowdy, M.H. Goodrow and B.D. Hammock.  2001.  Inhibition of microsomal epoxide hydrolases by ureas, amides and amines.  Chem Res Toxicol. 14:409-415. [PubMed]

Slim, R., B.D. Hammock, M. Toborek, L.W. Robertson, J.W. Newman, C.H.P. Morisseau, B.A. Watkins,V. Saraswathi, and B. Hennig.  2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells.  Toxicol Appl Pharmacol. 171(3):184-193. [PubMed]

Anderson, B.S., J.W. Hunt, B.M. Phillips, R. Fairey, H.M. Puckett, M. Stephenson, K. Taberski, J. Newman, R.S. Tjeerdema. 2001. Influence of sample manipulation on contaminant flux and toxicity at the sediment-water interface. Mar Environ Res. April, 2001. 51(3):191-211. [PubMed]

Newman, J.W., D.L. Denton, C. Morisseau, C.S. Koger, C.E. Wheelock, D.E. Hinton and B.D. Hammock.  2001.  Evaluation of fish models of soluble epoxide hydrolase inhibition.  Environ Health Persp. 109(1):61-6. [PubMed]

Yu, Z., F. Xu, L.M. Huse, C. Morisseau, A.J. Draper, J.W. Newman, C. Parker, L. Graham, M.M. Engler, B.D. Hammock, D.C. Zeldin and D.L. Kroetz.  2000.  Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.  Circ Res.  87(11):992-8. [PubMed]

Morisseau, C., J.K. Beetham, F. Pinot, S. Debernard, J.W. Newman and B.D. Hammock.  2000.  Cress and potato soluble epoxide hydrolases: Purification, biochemical characterization, and comparison to mammalian enzymes.  Arch. Biochem. Biophys.  378(2):321-32. [PubMed]

Greene, J.F., J.W. Newman, K.C. Williamson, and B.D. Hammock. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem Res Toxicol.  13(4):217-26. [PubMed]

Greene, J.F., K.C. Williamson, J.W. Newman, C. Morisseau, and B.D. Hammock.  2000.  Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification.  Arch Biochem Biophys.  376(2):420-32. [PubMed]

Newman, J.W., J.S. Becker, G. Blondina, and R.S. Tjeerdema.  1998.  Quantitation of Aroclors using congener specific results.  Environ Toxicol Chem.  17(11):2159-2167.

Morisseau, C., G. Du, J.W. Newman, and B. D. Hammock.  1998.  Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives. Arch Biochem Biophys.  356(2):214-28. [PubMed]

Fairey R., C. Roberts, M. Jacobi, S. Lamerdin , R. Clark , J. Downing, E. Long, J. Hunt, B. Anderson, J. Newman, R. Tjeerdema,  M. Stephenson, and C. Wilson.  1998.  Assessment of sediment toxicity and chemical concentrations in the San Diego Bay Region, California, USA.  Environ Toxicol Chem.  17(8):1570-81.

Anderson, B.S., J.W. Hunt, B.M. Phillips, S. Tudor, R. Fairey, J. Newman, H.M. Puckett, M. Stephenson, E.R. Long, R.S. Tjeerdema. 1998. Comparison of marine sediment toxicity test protocols for the amphipod Rhepoxynius abronius and the polychaete worm Nereis (Neanthes) arenaceodentata. Environ Toxicol Chem.  17(5):859-66.

Beckmen, K.B., L.J. Lowenstine, J. Newman, J. Hill, K. Hanni, and J. Gerber. 1997.  Clinical and pathological characterization of northern elephant seal skin disease.  J Wildlife Dis.  33(3):438-49. [PubMed]

Hunter, C. L., M.D. Stephenson, R.S. Tjeerdema, D.G. Crosby, G.S. Ichikawa, J.D. Goetzl, K.M. Paulson, D.B. Crane, M. Martin, and J.W. Newman.  1995.  Contaminants in oysters in Kaneohe Bay, Hawaii.  Mar Pollut Bull. 30: 646-54.

Newman, J.W., J. Vedder, W.M. Jarman, and R.R. Chang.  1994.  A method for the determination of environmental contaminants in living marine mammals using microscale samples of blubber and blood.  Chemosphere 28: 1795-805. [PubMed]