Guodong Zhang, Ph.D.

Guodong Zhang

Associate Professor | Associate Nutritionist in AES

3209 Meyer Hall | Labs: 3407 Meyer Hall

Dr. Zhang's research seeks to elucidate the molecular mechanisms for the health effects of dietary and/or environmental compounds, in order to better understand their metabolic individualities, address inter-individual susceptibilities, and clarify their health effects.

Publications
  • Wang W., Yang J., Zhang J., Wang Y., Hwang S., Qi W., Wan D., Kim D., Sun J., Sanidad K.Z., Yang H., Park Y., Liu J., Liu Z., Hammock B.D. and Zhang G. (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. PNAS 115:5283-5288. PMID: 29717038; PMCID: PMC5960306.
  • Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D., Zeldin D.C., and Zhang G. (2019) Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Research 79:1822-1830. PMID: 30803995; PMCID: PMC6467714.
  • Wang Y., Yang J., Wang W., Sanidad K.Z., Cinelli M.A., Wan D., Hwang S.H., Kim D., Lee K.S.S., Xiao H., Hammock B.D., and Zhang G. (2020) Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. PNAS 117: 8431-8436. PMID: 32220957; PMCID: PMC7165420.
  • Zhang J., Yang J., Duval C.N., Edin L.M., Williams A., Lei L., Tu M., Pourmand E., Song R., Graves J.P., DeGraff L.M., Wong J.L., Wang Y., Sun Q., Sanidad K.Z., Wong S., Han Y., Zhang Z., Lee K.S.S., Park Y., Xiao H., Liu Z., Decker E.A., Cui W., Zeldin D.C., and Zhang G. (2023) CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J 37(7):e23009. PMID: 37273180; PMCID: PMC10283155.
  • Wang Y., Wang W., Yang H., Shao D., Zhao X., and Zhang G. (2019) Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radical Biology & Medicine 131:237-242. PMID: 30503401.
  • Wang Y., Dattmore D.A., Wang W., Pohnert G., Wolfram S., Zhang J., Yang R., Decker E.A., Lee K.S.S., and Zhang G. (2019) trans, trans-2,4-decadienal, a lipid peroxidation product, induces inflammatory responses via Hsp90- or 14-3-3ζ-dependent mechanisms. Journal of Nutritional Biochemistry 76:108286. PMID: 31918337; PMCID: PMC7003550.
  • Lei L., Yang J., Zhang J., and Zhang G. (2021) The lipid peroxidation product EKODE exacerbates colonic inflammation and colon tumorigenesis. Redox Biology 42:101880. PMID: 33541845; PMCID: PMC8113040.
  • Wang W, Wang Y, Sanidad KZ, Wang Y, Zhang J, Yang W, Sun Q, Bayram I, Song R, Yang H, Johnson D, Sherman HL, Kim D, Minter LM, Wong JJL, Zeng MY, Decker EA, and Zhang G. (2024) Oxidized polyunsaturated fatty acid promotes colitis and colitis-associated tumorigenesis in mice. Journal of Crohn's and Colitis. doi: 10.1093/ecco-jcc/jjae148.
  • Yang H., Wang W., Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E. & Zhang G. (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Translational Medicine 10:eaan4116. Doi: 10.1126/scitranslmed.aan4116. PMID: 29848663; PMCID: PMC6343133.
  • Yang H., Sanidad K.Z., Wang W., Xie M., Gu M., Cao X., Xiao H. & Zhang G. (2019) Triclocarban exposure exaggerates colonic inflammation and colon tumorigenesis: roles of gut microbiota involved. Gut Microbes 24:1-12. Doi: 10.1080/19490976.2019.1690364. PMID: 31760871; PMCID: PMC7524142.
  • Wang G., Zhang H., Zhang J., Sanidad K.Z., Parsonnet J., Haggerty T.D., Yang H., Ai L., Xie M., Cai Z., and Zhang G. (2021) Roles of gut microbiota in metabolism and pharmacokinetics of environmental chemical triclocarban. Science of the Total Environment 787:147677. Doi: 10.1016/j.scitotenv.2021.147677. PMID: 34004538; PMCID: PMC8192447.
  • Zhang J., Gibbs M.E., Sanidad K.Z., Zhang H., Liang Y., Zhao E., Chacon-Vargas K., Yeliseyev V., Parsonnet J., Haggerty T.D., Wang G., Simpson J.B., Jariwala P.B., Beaty V.V., Yang J., Yang H., Panigrahy A., Minter L.M., Kim D., Gibbons J.G., Liu L., Xiao H., Borlandelli V., Overkleeft H.S., Cloer E.W., Major M.B., Goldfarb D., Cai Z., Redinbo M.R., and Zhang G. (2022) Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nature Communications 13, Doi: 10.1038/s41467-021-27762-y. PMID: 35013263; PMCID: PMC8748916.