Gerardo Mackenzie, Ph.D.

 Gerardo  Mackenzie, Ph.D.

Position

  • Assistant Professor
  • Department of Nutrition

Contact

Education

  • Ph.D., Cell Biology, University of Buenos Aires, Argentina
  • B.S./M.S., Biochemistry,  University of Buenos Aires, Argentina

Research Interests

Dr. Mackenzie´s research focuses on the role of diet and other lifestyle factors in cancer development and prevention. Current research projects include: 1) Understanding the cellular and molecular mechanisms involved in the link between obesity, inflammation and cancer; 2) Evaluating the role of zinc in pancreatic carcinogenesis; and 3) Investigating the use of select nutraceuticals as potential chemopreventive agents.

Selected Publications

Matteolabakis G, Wang R, Rigas B and Mackenzie GG. Phospho-Valproic Acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)lactic acid-poly(ethylene glycol) nanoparticles. International Journal of Oncology Oct; 51(4):1035-1044. 2017 Oct. [PubMed]

Supasai S, Aimo L, Adamo AM, Mackenzie GG and Oteiza PI. Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms. Redox Biology 11:469-48. 2017 Apr. [PubMed]

Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG and Oteiza PI. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via a redox-regulated mechanisms. Molecular Carcinogenesis Aug 56(8):1868-1883. 2017 Apr. [PubMed]

Mattheolabakis G, Papayannis I, Yang J, Vaeth BM, Wang R, Bandovic J, Ouyang N, Rigas B and Mackenzie GG. Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice. Cancer Prev Res (Phila). 2016 Jul;9(7):624-34. [PubMed]

Bartels LE, Mattheolabakis G, Vaeth BM, LaComb JF, Wang R, Zhi J, Komninou D, Rigas B and Mackenzie GG. The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: An effect mediated by cyclin D1. Carcinogenesis. 2016 Apr;37(4):420-9. [PubMed]

Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, and Oteiza PI. The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth. Mol Carcinog. 2016 Jan 15. (epub ahead of print) [PubMed]

Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, and Oteiza PI. Gestational Marginal Zinc Deficiency Impaired Fetal Neural Progenitor Cell Proliferation by Disrupting the ERK1/2 Signaling Pathway. Journal of Nutritional Biochemistry. Journal of Nutritional Biochemistry. 2015 Nov;26(11):1116-23 (2015). [PubMed]

Son JS, Khair S, Pettet III DW, Ouyang N, Tian X, Zhang Y, Zhu W, Mackenzie GG, Robertson CE, Ir D, Frank DN, Rigas B and Ellen Li. Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice. PLoS ONE; Jun 29;10(6):e0127985. doi: 10.1371/journal.pone.0127985 (2015). [PubMed]

Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B. Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress. BCM Cancer Feb 28; 14:141 (2014). [PubMed]

Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N and Rigas B. A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice. Neoplasia 15(10): 1184-95 (2013). [PubMed]

Mackenzie GG, Huang L, Alston N, Ouyang N, Vrankova K, Mattheolabakis G, Constantinides PP and Rigas B. Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice. PLoS ONE 8(5): e61532; (2013). [PubMed]

Cheng KW, Wong CC, Alston N, Mackenzie GG, Huang L, Ouyang N, Xie G, Wiedmann T, Rigas B. Aerosol administration of phospho-sulindac inhibits lung tumorigenesis. Mol Cancer Ther. [PubMed]

Mattheolabakis G, Mackenzie GG, Huang L, Ouyang N, Cheng KW and Rigas B. Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats. Pharmaceutical Research Jun;30(6):1471-82 (2013). [PubMed]

Zhou D, Papayannis I, Mackenzie GG, Alston N, Ouyang N, Huang L, Nie T, Wong CC and Rigas B. The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies. Carcinogenesis. Apr;34(4):943-51 (2013). [PubMed]

Zhu R, Cheng KW, Mackenzie GG, Huang L, Sun Y, Xie G, Vrankova K, Constantinides PP and Rigas, B. Phospho-Sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: Enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles Pharmaceutical Research. Nov;29(11):3090-101. (2012). [PubMed]

Sun Y, Rowehl LM, Huang L, Mackenzie GG, Vrankova K, Komninou, D and Rigas, B. Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. Breast Cancer Research. Jan 31;14(1):R20 (2012). [PubMed]

Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Komninou, D, Kopelovich L, and Rigas, B. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. British Journal of Pharmacology. 165(7):2152-66 (2012). [PubMed]

Huang L, Mackenzie GG, Sun Y, Xie G, Johnson F, Komninou D and Rigas, B. Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds. Cancer Research; Dec 15; 71(24):7617-27 (2011). [PubMed]

Mackenzie GG, Salvador GA, Romero C, Keen, CL, and Oteiza, PI. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radical Biology & Medicine 51(2): 480-489 (2011). [PubMed]

Sun Y, Huang L, Mackenzie GG, and Rigas B. Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: Implications for the role of oxidative stress in the action of anticancer agents. The Journal of Pharmacology and Experimental Therapeutics. Sep;338(3):775-83 (2011). Highlighted by the editors as one in 4 out of 31 papers in the issue; in the journal’s section: “Highlighted Papers”; JPET 2011; 338: 731. [PubMed]

Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L and Rigas B. Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer Prevention Research. Jul;4(7):1052-60 (2011). [PubMed]

Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D and Rigas B. Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, pharmacokinetics and pharmacodynamics in mouse models. The Journal of Pharmacology and Experimental Therapeutics. Jun;337(3):876-886 (2011). Highlighted by the editors as one in 4 out of 34 papers in the issue; in the journal’s section: “Highlighted Papers”; JPET 2011; 337: 571. [PubMed]

Huang L, Mackenzie GG, Ouyang N, Sun Y, Xie G, Johnson F, Komninou D and Rigas, B. The novel phospho-NSAIDs OXT-328, MDC-22 and MDC-917 inhibit adjuvant-induced arthritis in the rat. British Journal of Pharmacology: Apr;162(7):1521-33. (2011). [PubMed]

Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, and Rigas B. Phospho-Sulindac (OXT-328), a novel sulindac derivative, is safe and effective for colon cancer prevention in mice. Gastroenterology 139(4):1320-32 (2010). Highlighted by the editors as one in 4 out of 40 papers in the issue; in the journal’s section: “This month in Gastroenterology”; Gastroenterology 2010; 139: 1069-1072. [PubMed]

Huang L, Zhu CH, Sun, Y, Xie G, Mackenzie GG, Qiao G, Komninou D. and Rigas B. Phosphosulindac (OXT-922) inhibits the growth of human colon cancer cell lines: A redox/polyamine dependent effect. Carcinogenesis: Nov;31(11):1982-90 (2010). [PubMed]

Verstraeten SV, Mackenzie GG, and Oteiza, P.I. The plasma membrane plays a central role in cells response to mechanical stress. Biochimica et Biophysica Acta 1798: 1739-1749 (2010). [PubMed]

Aimo L., Mackenzie GG, Keenan AH and Oteiza, P.I. Gestational Zinc deficiency affects the regulation of transcription factor AP-1, NF-κB and NFAT in fetal brain. J Nutritional Biochemistry Nov;21(11):1069-75 (2010). [PubMed]

Adamo AM, Zago MP, Mackenzie GG, Aimo L., Keen CL, Keenan AH and Oteiza PI. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res. 17(1):1-14 (2010). [PubMed]

Hua A, Mackenzie GG and Rigas B. The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin. International Journal of Oncology 35(4):837-844 (2009). [PubMed]

Mackenzie GG, Delfino JM., Keen CL, Fraga CG and Oteiza P.I. The interaction between dimeric procyanidins and the DNA-binding sites of transcription factor NF-κB. Biochemical Pharmacology Nov 1;78(9):1252-62 (2009). [PubMed]

Zhao W, Mackenzie GG, Murray OT, Zhang Z. and Rigas B. Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: A redox-dependent effect. Carcinogenesis; 30(3):512-9 (2009). [PubMed]

Verstraeten SV, Mackenzie GG, Oteiza PI and Fraga, C.G. (-)Epicatechin and related procyanidins modulate intracellular calcium and prevented oxidation in Jurkat T cells. Free Radical Research 42(10):864-72 (2008). [PubMed]

Mackenzie GG, Rasheed S, Wertheim W and Rigas B. NO-donating-NSAIDs, PPARδ and Cancer: Does PPARδ contribute to colon carcinogenesis? PPAR Research 2008;2008:919572. [PubMed]

Mackenzie GG, Queisser N, Wolfson, M., Fraga CG, Adamo AM and Oteiza PI. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutive active NF-κB and STAT3 pathways in Hodgkin’s lymphoma. International J. Cancer 123(1):56-65. (2008).  [PubMed]

Mackenzie GG, Adamo AM, Decker NP and Oteiza PI. Dimeric procyanidin B2 inhibits constitutively active NF-κB and NF-κB-dependent gene expression in Hodgkin’s lymphoma cells. Biochemical Pharmacology 75:1461-1471 (2008).[PubMed]

Mackenzie GG, Zago MP, Aimo L and Oteiza PI. Zinc deficiency in neuronal biology. IUBMB Life 59(4-5): 299-307 (2007).[PubMed]

Mackenzie GG and Oteiza PI. Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. Journal of Cellular Physiology 210(1):246-256 (2007).[PubMed]

Mackenzie GG and Oteiza PI. Modulation of transcription factor NF-κB in Hodgkin’s lymphoma cell lines: effect of (-)-epicatechin. Free Radical Research 40(10):1086-1094 (2006).[PubMed]

Mackenzie GG, Keen CL and Oteiza PI. Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. Journal of Neurochemistry 99(2): 402-415 (2006).[PubMed]

Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL and Oteiza PI. α-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-κB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radical Research. 40(1):75-84 (2006).[PubMed]

Zago MP, Mackenzie GG, Adamo AM, Keen CL and Oteiza PI. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H2O2. Antioxid Redox Signal. 7(11-12):1773-82 (2005).[PubMed]

Oteiza PI. and Mackenzie GG. Zinc, oxidant-triggered cell signaling, and human health. Molecular Aspects of Medicine 26(4-5):245-255 (2005).[PubMed]

Oteiza PI, Mackenzie GG and Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Molecular Aspects of Medicine 25(1-2):103-15 (2004).[PubMed]

Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG and Oteiza PI. Epicatechin, catechin and dimeric procyanidins inhibit PMA-induced NF-κB activation at multiple steps in Jurkat T cells. FASEB Journal 18: 167-169 (2004).[PubMed]

Verstraeten SV, Zago MP, Mackenzie GG, Keen CL and Oteiza PI. Influence of zinc deficiency on cell membrane fluidity in Jurkat T, 3T3 and IMR-32 cells. Biochemical Journal 378:579-587 (2004).[PubMed]

Actis-Goretta L, Mackenzie GG, Oteiza PI and Fraga CG. Comparative study of the antioxidant capacity of wines and other plant-derived beverages. Annals of the New York Academy of Sciences 957: 279-83 (2002). [PubMed]

Mackenzie GG, Keen CL and Oteiza PI. Zinc status of human neuroblastoma IMR-32 cells influences their susceptibility to iron-induced oxidative stress. Developmental Neuroscience 24: 125-133 (2002).[PubMed]

Mackenzie GG, Zago MP, Keen CL and Oteiza PI. Low intracellular zinc impairs the translocation of activated NF-κB to the nuclei in human neuroblastoma IMR-32 cells. Journal of Biological Chemistry 277:34610-34617 (2002). [PubMed]