UNIVERSITY OF CALIFORNIA
COOPERATIVE EXTENSION

NUTRITION PERSPECTIVES

Volume 26, No. 5
September/October 2001

TABLE OF CONTENTS

Governor Has Signed SB 19 (Escutia): School Nutrition
Life Expectancy Hits New High in 2000; Mortality Declines For
Several Leading Causes of Death

Diet, Exercise Delay Type 2 Diabetes
As Diabetes Epidemic Surges, HHS and ADA Join Forces to Fight Heart Disease,
the Leading Cause of Death for People with Diabetes

Obesity and Diabetes Still On the Rise in US
Healthful Weight, Proper Diet, and Exercise Could Prevent Diabetes
Use of Weight Loss Products by Adults
Physicians Influence Fitness
Obesity Linked To Early Puberty in Young Girls
'Miracle' Health Claims: Add a Dose of Skepticism
Folic Acid Reminder
Is Folic Acid Fortification Preventing Neural Tube Defects?
Alternative Medicine Is No Fad
Soy Foods: Should You or Shouldn't You?

Resources:

Prenatal & Infant Nutrition for Teens
Nutrition/Physical Resources on the Web
HHS Media Advisory

Subscription for NUTRITION PERSPECTIVES

Sheri Zidenberg-Cherr, PhD, Editor Department of Nutrition University of California Davis, CA 95616

NUTRITION PERSPECTIVES is prepared by Sheri Zidenberg-Cherr, PhD, Nutrition Specialist, Cristy Hathaway, and staff. It is designed to provide research-based information on ongoing nutrition and food-related programs. It is published bimonthly (six times annually) as a service of the University of California Cooperative Extension and the United States Department of Agriculture. Subscription to NUTRITION PERSPECTIVES is available from UC Cooperative Extension, Department of Nutrition, University of California, Davis, California. Cost is ten dollars ($10.00) for a one-year subscription. Subscriptions and questions or comments on articles may be addressed to: NUTRITION PERSPECTIVES, Department of Nutrition, University of California, Davis, CA 95616-5270. Phone (916)752-3387; FAX, (916) 752-8905.

GOVERNOR HAS SIGNED SB 19 (ESCUTIA): SCHOOL NUTRITION

The bill establishes specific nutrition standards for food and beverages sold in elementary schools, prohibits the sale of sodas until after the last lunch period in middle schools, and increases the State's reimbursement for school meals by 10 cents. Below is a summary of the final bill.

Summary of provisions:

1. Sets nutritional standards for foods sold in elementary schools:
Any snacks sold outside the federal meal program must
· Have no more than 35 percent of its calories from fat
· Have no more than 10 percent of its calories from saturated fat
· Be no more than 35 percent sugar by weight
The only beverages that may be sold to students are milk, water or juice that is at least 50 percent fruit juice with no added sweeteners.

2. In middle schools carbonated beverages may be sold only after the end of the last lunch period.

3. High schools and middle schools may elect to take part in a pilot program that implements the nutritional standards for all foods and beverages sold outside the federal meal program.
· They will be eligible for the increased reimbursement rate stated below in number 4, and a planning grant stated below in number 5.

4. The bill increases the reimbursement rate for free- and reduced-price meals in elementary and middle schools by 10 cents from the current 13 cents to 23 cents. Meals purchased at full price by children will be reimbursable at a rate of 10 cents per meal.

5. Districts with elementary schools, middle schools or high schools participating in the pilot program may apply for planning grants to be used for developing other policies related to nutrition and physical activity.
· Funds may be used for costs associated with developing and adopting these policies, including paid release time for teachers and school employees, publication costs, costs associated with holding a public hearing, etc.

Costs:
· Year 1: $5 million (grants and technical support)
· Year 2: $5 million (grants and technical support)
· Year 3: $30 million (one-half year of increased reimbursement rates)
· Year 4 and ongoing: $60 million for increased reimbursement rates.

Note:
· SB 19 does NOT restrict food services on high schools, unless they volunteer for the pilot.
· SB 19 does NOT restrict the sale of candy for fundraisers when those sales take place at home or in the community.
· SB 19 does NOT prohibit the sale of sodas in middle schools. It allows such sales after the end of the last lunch period.
Source: Online at: http://democrats.sen.ca.gov/senator/escutia/; October 5, 2001

LIFE EXPECTANCY HITS NEW HIGH IN 2000; MORTALITY DECLINES FOR
SEVERAL LEADING CAUSES OF DEATH

Life expectancy for the US population reached a record high of 76.9 years in 2000 as mortality declined for several leading causes of death, according to preliminary figures from a report released by HHS' Centers for Disease Control and Prevention (CDC).

"Americans on average are living longer than ever before, and much of this is due to the progress we've made in fighting diseases that account for a majority of deaths in the country," HHS Secretary Tommy G. Thompson said. "But we can do even more by eating right, exercising regularly and taking other simple steps to promote good health and prevent serious illness and disease."

The estimates are featured in a new CDC report, "Deaths: Preliminary Data for 2000," an analysis of over 85 percent of the death certificates recorded in the United States for 2000.

The report shows that age-adjusted death rates continued to fall for heart disease and cancer, the two leading causes of death in the US that account for more than half of all deaths in the country each year. Mortality from heart disease has declined steadily since 1950, while cancer mortality has been on the decline since 1990.
Age-adjusted death rates also fell for other leading causes of death, including: homicide, suicide, accidents or "unintentional injuries," stroke, diabetes, chronic lower respiratory diseases, and chronic liver disease and cirrhosis.

In addition, the preliminary infant mortality rate in the US fell to its lowest level ever in 2000, 6.9 infant deaths per 1,000 live births, down from a rate of 7.1 in 1999.
"A healthy pregnancy is a major factor in reducing the risk of infant death," said CDC Director Jeffrey Koplan. "Timely prenatal care and avoiding harmful behavior like smoking are two examples of how pregnant mothers can protect the health of their infants."

The report also shows that mortality decreased by 3.7 percent for HIV infection in 2000, the fifth straight year of decline. After increasing every year between 1987 and 1994 at an average of 16 percent annually, HIV mortality leveled off in 1995, dropped 29 percent in 1996, 48 percent in 1997, and 21 percent in 1998, before slowing to a 3.6 percent decline in 1999.

Meanwhile, mortality increased for certain leading causes of death, including Alzheimer's disease, influenza and pneumonia, kidney disease, hypertension, septicemia, and pneumonitis due to solids and liquids, a condition that disproportionately affects the aging population and which emerged for the first time as one of the 15 leading causes of death.

"Information is often the most effective weapon we have against many of these problems, and having timely data gives us better information," said Dr. Edward Sondik, director of CDC's National Center for Health Statistics, which prepared the report.

Information on causes of death is recorded on death certificates by physicians, medical examiners and coroners, and reported to the state vital statistics offices. Demographic information is provided by funeral directors, based on information from informants, who are usually family members.

The report can be found online at the CDC Web site: http://www.cdc.gov/nchs. Note: All HHS press releases, fact sheets and other press materials are available at www.hhs.gov/news.
Source: HHS Press Release; October 10, 2001.


DIET, EXERCISE DELAY TYPE 2 DIABETES

At least 10 million Americans at high risk for Type 2 diabetes can sharply lower their chances of getting the disease with diet and exercise, a major clinical trial indicates (1).

"In view of the rapidly rising rates of obesity and diabetes in America, this good news couldn't come at a better time," said Health and Human Services Secretary Tommy G. Thompson in announcing the findings August 9 at the National Institutes of Health (NIH). "So many of our health problems can be avoided through diet, exercise and making sure we take care of ourselves."

The study also found that treatment with the oral diabetes drug Glucophage (metformin) reduces diabetes risk, though less dramatically, in people at high risk for Type 2 diabetes.

Participants who were randomly assigned to intensive lifestyle intervention reduced their risk of getting Type 2 diabetes by 58 percent. On average, this group maintained their physical activity at 30 minutes a day, usually with walking or other moderate-intensity exercise, and lost 5 percent to 7 percent of their body weight. Participants picked randomly to receive treatment with Glucophage reduced their risk of getting Type 2 diabetes by 31 percent.

The study, called the Diabetes Prevention Program (DPP), compared diet and exercise to treatment with Glucophage in 3,234 people with impaired glucose tolerance (IGT), a condition that often precedes diabetes. The trial clearly answered the main research questions.

The DPP, conducted at 27 centers nationwide, is sponsored by the NIH. It is the first major trial to show that diet and exercise can effectively delay diabetes in a diverse American population of overweight people with IGT, a condition in which blood glucose levels are higher than normal but the individual is not yet considered to have diabetes.

Forty-five percent of the participants enrolled in the DPP were from minority groups that suffer disproportionately from Type 2 diabetes: African Americans, Hispanic Americans, Asian Americans and Pacific Islanders, and American Indians. The trial also recruited other groups known to be at higher risk for Type 2 diabetes, including people age 60 and older, women with a history of gestational diabetes, and people with a first-degree relative with Type 2 diabetes.
Lifestyle intervention worked as well in men and women and in all the ethnic groups, according to the study's chairman, David Nathan, MD, of Massachusetts General Hospital in Boston. It also worked well in people age 60 and older, reducing the development of diabetes in this group by 71 percent. Glucophage was effective in men and women and in all the ethnic groups, but was relatively ineffective in the older volunteers and in those who were less overweight.

DPP volunteers were randomly assigned to one of the following groups:
· Intensive lifestyle changes with the aim of reducing weight by 7 percent through a low-fat diet and exercising for 150 minutes a week;
· Treatment with Glucophage (850 mg twice a day), a drug approved in 1995 to treat Type 2 diabetes; or
· A standard group taking placebo pills in place of Glucophage.

The later two groups also received information on diet and exercise. DPP participants ranged form age 25 to 85, with an average age of 51. Upon entry to the study, all had impaired glucose tolerance as measured by an oral glucose tolerance, and all were overweight, with an average body mass index (BMI) of 34. (A BMI of 25 or more, or 27 after age 35, indicates obesity.) About 29 percent of the DPP standard group developed diabetes during the average follow-up period of three years. In contrast, 14 percent of diet and exercise group and 22 percent of the Glucophage group developed diabetes.

Volunteers in the diet and exercise group achieved the study goal, on average a 7 percent, or 15-pound, weight loss, in the first year and generally sustained a 5 percent total loss for the study's duration. Participants in this lifestyle intervention group received training in diet, exercise (most chose walking), and behavior modification skills.

Can the interventions prevent diabetes altogether? "We simply don't know how long, beyond the 3-year period studied, diabetes can be delayed," says Nathan. "We hope to follow the DPP population to learn how long the interventions are effective." The researchers will analyze the data to determine whether the interventions reduced cardiovascular disease and atherosclerosis, major causes of death in people with diabetes.

Reference:

1. The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care. 1999 Apr;22(4):623-34.
Source: FDA Consumer; 35(5); September-October 2001; pp. 10-11.


AS DIABETES EPIDEMIC SURGES, HHS AND ADA JOIN FORCES TO FIGHT HEART DISEASE, THE LEADING CAUSE OF DEATH FOR PEOPLE WITH DIABETES

A new emphasis on treating diabetes comprehensively, that is, managing not only blood glucose, but also blood pressure, and cholesterol, could save lives, according to the U.S. Department of Health and Human Services (HHS), the National Diabetes Education Program (NDEP) and the American Diabetes Association (ADA). NDEP is co-sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Centers for Disease Control and Prevention.
Marking November as national diabetes month, HHS and its partners are joining forces to inform the public that good diabetes management is more than lowering blood glucose. Control of blood pressure and cholesterol is crucial to help prevent heart disease and stroke, the leading killers of people with diabetes. New guidelines for blood pressure and LDL cholesterol in people with diabetes are lower than for the general population and similar to those for people with known heart disease. This new public awareness campaign comes in response to new studies that show a dramatic link between diabetes and heart disease. Research now shows that people with diabetes can live longer and healthier lives with relatively small decreases in blood glucose, blood pressure and cholesterol.

"With 16 million people and counting, diabetes is growing at an alarming rate in America," said HHS Secretary Tommy G. Thompson. "Diabetes has increased 49 percent from 1990 to 2000 and projections indicate a 165 percent increase by the year 2050. If you have diabetes, you are at a very high risk for heart attack and stroke. But you can take control and lower your risk with this new treatment approach."

To communicate the importance of comprehensive care in simple language, the "ABCs of diabetes" have been developed. The A stands for the A1C (a-one-see), or hemoglobin A1C test, which measures average blood glucose (sugar) over the previous 3 months. B is for blood pressure, and C is for cholesterol. This approach was developed because the vast majority of people with diabetes don't know that they are at very high risk of cardiovascular disease and that this risk can be greatly reduced with appropriate treatment. Research shows that 75 percent of people with diabetes die from heart disease and stroke, and they die younger than the general population.

"The American Diabetes Association is delighted to support NDEP in getting the word out about the 'ABCs of Diabetes,'" said Dr. John Buse, Chair of the Association's Cardiovascular Initiative, entitled "Make the Link." "The ABCs of Diabetes is a clear message for both patients and healthcare providers that it's not just glucose that matters if you want to help prevent heart disease and stroke."

"People with diabetes know how important it is to control their blood glucose, but too little attention is paid to the role of cholesterol and blood pressure," said Allen M. Spiegel, MD, NDEP spokesperson and director of the NIDDK at the National Institutes of Health (NIH). "Research shows that this new approach, aggressively treating these three risk factors, can save lives."

Recommended Targets:

· A1C less than 7 percent. Check at least twice a year.
· Blood pressure below 130/80. Check at every doctor's visit.
· Cholesterol (LDL) below 100. Check at least once a year.

Questions to Ask

· What are my A1C, blood pressure, and cholesterol numbers?
· What are my treatment goals?
· What do I need to do to reach and maintain my goals?

The same steps needed to control blood glucose work for controlling blood pressure and cholesterol: stay at a healthy weight; follow a healthy diet; get daily physical activity; don't smoke; and take prescribed medications.

NDEP and ADA have developed a new tool: a new brochure for people with diabetes that provides essential information and has a wallet card to help them track their ABC numbers. It's free, and part of a new, national public education campaign, Be Smart about Your Heart: Control the ABCS of Diabetes. To get the new brochure and the free wallet card and to learn more about diabetes, call 1-800-438-5383 or visit NDEP's Web site at http://ndep.nih.gov or contact the ADA at 1-800-DIABETES or visit www.diabetes.org/makethelink.

The National Diabetes Education Program is jointly sponsored by NIH and the Centers for Disease Control and Prevention (CDC) and 200 public and private partners. The American Diabetes Association is the nation's leading voluntary health organization supporting diabetes research, information and advocacy. Founded in 1940, the ADA has offices in every region of the country, providing services to more than 800 communities.

Source: HHS Press Release; November 1, 2001.


OBESITY AND DIABETES STILL ON THE RISE IN US

The prevalence of obesity in the United States increased 61 percent from 1991 to 2000, according to a current study (1). Diabetes also increased in that same time period by 49 percent. In 2000, 19.8 percent of adults were obese, 56.4 percent were overweight, and more than 7 percent had diabetes. The results were taken from the CDCs Behavioral Risk Factor Surveillance System, a random-digit telephone survey of 184,450 people. Weight, height, and diagnosis of diabetes were self-reported by the survey respondents. The authors concluded that obesity and diabetes will likely continue to increase unless effective interventions are implemented. To read the study, go to www.jama.com.

Reference:

1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA; September 2001; 12;286(10):1195-200.

Source: Nutrition Week; XXXI(34); September 17, 2001; p. 6.


HEALTHFUL WEIGHT, PROPER DIET, AND EXERCISE
COULD PREVENT DIABETES

Women who aren't overweight, exercise at least half an hour a day, and eat a diet high in fiber reduce their risk of type 2 diabetes by 90 percent, according to a recent study (1). These women also ate a diet low in glycemic index and trans fat. Researchers form the Harvard School of Public Health followed 84,941 women as part of the Nurses Health Study form 1980-1996. During that time, overweight or obesity was the single most important predictor of diabetes, contributing to 61 percent of the cases of type 2 diabetes in the study. Lack of exercise, a poor diet, smoking, and abstinence from alcohol were also associated with a significant increased risk for diabetes. To read an abstract of the study, go to www.nejm.org

Reference:

1. Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med; September 2001; 13;345(11):790-7.

Source: Nutrition Week; XXXI(34); September 17, 2001; p. 6.


USE OF WEIGHT LOSS PRODUCTS BY ADULTS

Nearly 7 percent of surveyed adults, 30 percent of which included young obese women, use non-prescription weight loss products, according to a recent study (1). In a survey of 14,679 adults aged 18 of older, women and younger adults were the most frequent users of non-prescription weight loss products, including ephedra, which has been linking to adverse health effects. Almost 8 percent of normal-weight women also used non-prescription weight loss products. In their report, Blanck and colleagues state that they believe that the use of these products will only increase obesity rates in the United States. To read the article abstract, go to http://jama.amaassn.org/issues/v286n8/abs/joc10285.html.

Reference:

1. Blanck HM, Khan LK, Serdula MK. Use of nonprescription weight loss products: results from a multistate survey. JAMA; August 2001; 22-29;286(8):930-5.

Source: Nutrition Week; XXXI(34); September 3, 2001; p. 7.


PHYSICIANS INFLUENCE FITNESS

As few as 3 hours of counseling by health care workers over 2 years can boost sedentary adults' physical fitness, according to a study form the National Heart, Lung, and Blood Institute (NHLBI) (1). At the beginning of the trial, only 1 percent of volunteers met federal recommendations for physical activity. Two years later, about 20 percent did. Director Claude Lefant said the results mean that time-crunched physicians and their staff can still have an important effect on patients' health.
The study of 874 adults compared three types of education and counseling, ranging from 4-minute "advice sessions" to regular telephone counseling and weekly support classes. For women, the more intense intervention led to more activity. However, for men the short sessions were just as effective as the long.

Fitness was measured by oxygen uptake during a treadmill test, while physical activity was self-reported. The NHLBI said the study is the first controlled trial to compare the effects of various methods of education and counseling on long-term physical fitness.

Reference:

1. Simons-Morton DG, Hogan P, Dunn AL, Pruitt L, King AC, Levine BD, Miller ST. Characteristics of inactive primary care patients: baseline data from the activity counseling trial. For the Activity Counseling Trial Research Group. Prev Med; November 2000; 31(5):513-21.

Source: JAMA; 286(11); September 19, 2001; p. 1306.


OBESITY LINKED TO EARLY PUBERTY IN YOUNG GIRLS

Obesity is related to early puberty in girls, according to a study from the American Academy of Pediatrics' 1,600-member national practice-based research network, Pediatric Research in Office Settings (PROS) (1).

The study found that 6- to 9-year-old girls who had started developing breasts or pubic hair were significantly more overweight than girls of the same age who had not. The study also found that this association was stronger for white girls than for black girls, but it could not account for the finding that black girls started puberty, on average, one year earlier than white girls.

Virginia Commonwealth University School of Medicine pediatric endocrinologist Paul Kaplowitz, MD, FAAP, collaborated with the authors of a 1997 PROS study to re-examine puberty data on 17,000 girls between the ages of 3 and 12 years old, after accounting for the girls' body mass indexes.

The original PROS study of secondary sexual characteristics was conducted in the mid-1990s. Findings from this study suggest that girls in the United States, particularly black girls, are beginning puberty at younger ages than studies found several decades ago, but the reasons are not clear. However, because nutritional status affects the timing of puberty and knowing that there is a trend for increasing obesity in US children, the authors of the recently published article sought to better define the relationship between obesity and early puberty in girls.

Based on these findings, physicians should anticipate that overweight girls are more likely to show signs of early puberty and physicians should take obesity and racial status into account when deciding how to manage early-maturing 6- to 9-year-old girls.

Practitioners seeking more information about joining PROS should contact PROS Central at (800) 433-9016, ext. 7623; e-mail PROS at pros@aap.org.
The PROS Secondary Sexual Characteristics study was supported by the Health Resources and Services Administration Maternal and Child Health Bureau, and Genentech Inc.

Reference:

1. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics; August 2001; 108(2):347-53.

Source: AAP News; 19(3); September 2001; p. 107.

'MIRACLE' HEALTH CLAIMS: ADD A DOSE OF SKEPTICISM

Whether they're looking for a short cut to losing weight or a cure for a serious ailment, consumers may be spending billions of dollars a year on unproven, fraudulently marketed, often useless health-related products, devices and treatments. Why? Because health fraud trades on false hope. It promises quick cures and easy solutions to a variety of problems, from obesity to cancer and AIDS. But consumers who fall for fraudulent "cure-all" products don't find help or better health. Instead, they find themselves cheated out of their money, their time, and maybe even their health. Fraudulently marketed health products can keep people from seeking and getting treatment from their own healthcare professional. Some products can cause serious harm, and many are expensive because health insurance rarely covers unapproved treatments.

To avoid becoming victims of health fraud, it's important for consumers to learn how to assess health claims and seek the advice of a health professional.

Common Health Fraud Targets

Officials at the Federal Trade Commission (FTC) and the Food and Drug Administration (FDA) say health fraud promoters often target people who are overweight or have serious conditions for which there are no cures, including multiple sclerosis, diabetes, Alzheimer's disease, cancer, HIV and AIDS, and arthritis.

Cancer

A diagnosis of cancer can bring feelings of fear and hopelessness. Many people may be tempted to turn to unproven remedies promoted as cancer cures. But they and their loved ones should be skeptical of "miracle" claims because no single device, remedy or treatment can treat all types of cancer. Cancer is a name given to a wide range of diseases; each requires different forms of treatment that are best determined with the advice of a health professional.

Cancer patients who want to try an experimental treatment should enroll in a legitimate clinical study. The FDA reviews clinical study designs to help ensure that patients are not subjected to unreasonable risks.

For more information about cancer treatments, contact the American Cancer Society; the nearest local chapter will be listed in the yellow pages of your phone book.

For free publications on cancer research and treatment, call the National Cancer Institute's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) or log on to http://cancernet.nci.nih.gov/.

HIV and AIDS

Although legitimate treatments can extend life and improve the quality of life for people with AIDS, there is, so far, no cure for the disease. People diagnosed with HIV, the virus that causes AIDS, may want to try untested drugs or treatments. But trying unproven products or treatments, such as electrical and magnetic devices and so-called herbal cures, can be dangerous and may cause HIV-positive individuals to delay seeking medical care.

An example is the herb St. John's Wort, which has been promoted as a safe treatment for HIV. There is no evidence that this herb is effective in treating HIV, and in fact, studies have shown that it interferes with medicines prescribed for HIV.

People who think they may be HIV-positive may turn to home test kits. But claims for these products may be misleading and possibly harmful. Safe, reliable HIV testing can be done only through a medical professional or a clinic, or through the Home Access Express HIV-1 Test System; it is the only system approved for home use by the FDA.

The US government has a toll-free HIV-AIDS Treatment Information Service, 1-800-HIV-0440 (1-800-448-0440), which is staffed by English- and Spanish-speaking health information specialists. Information also is available at www.hivatis.org.

Arthritis

Consumers spend an estimated $2 billion a year on unproven arthritis remedies - thousands of dietary and so-called natural cures, like mussel extract, desiccated liver pills, shark cartilage, CMO (cetylmyristoleate), honey and vinegar mixtures, and magnets and copper bracelets. But these remedies are not backed by adequate science to show that they offer long-term relief. For current, accurate information on arthritis treatments and alternative therapies, call the Arthritis Foundation at 1-800-283-7000 or visit its website at www.arthritis.org.

Assessing Claims for Dietary Supplements

The array of dietary supplements, vitamins and minerals, amino acids, enzymes, herbs, animal extracts and others, has grown tremendously over the years. Although the benefits of some of these products have been documented, the advantages of others are unproven.

For example, claims that a supplement allows you to eat all you want and lose weight effortlessly are false. To lose weight, you must lower your calorie intake or burn more calories, for example, by increasing exercise. Most medical experts recommend doing both.

Similarly, no supplement can cure arthritis or cancer in five days. Such claims are false. Consumers should be wary of any claims for a dietary supplement that say it can shrink tumors, cure insomnia, cure impotency, treat Alzheimer's disease, or prevent severe memory loss. These kinds of claims deal with the treatment of diseases, and companies that want to make such claims must follow the FDA's pre-market testing and review process required for new drugs.

FDA Regulation of Health Claims

Federal law allows for certain claims to be made in the labeling of food and supplements. These include claims approved by the Food and Drug Administration that show a strong link, based on scientific evidence, between a food substance and a disease or health condition. These approved claims can state only that a food substance reduces the risk of certain health problems, not that it can treat or cure a disease. Two examples of approved claims are: "The vitamin folic acid may reduce the risk of neural tube defect-affected pregnancies," and "Calcium may reduce the risk of the bone disease osteoporosis."

Dietary supplements also may carry claims in their labeling that describe the effect of a substance in maintaining the body's normal structure or function, as long as the claims don't imply the product treats or cures a disease. The FDA does not review or authorize these claims. An example of such a claim is, "Product B promotes healthy joints and bones." When a dietary supplement is promoted with a claim like this, the claim must be accompanied with the disclaimer, "This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease."

To learn more about the kinds of labeling claims that can be made for foods and dietary supplements, see www.cfsan.fda.gov/~dms/hclaims.html.

Safety Concerns

Prescription drugs must undergo clinical testing and receive the FDA's full review for safety and effectiveness before they are sold. Over-the-counter medicines are subject to the OTC drug review process, which determines safety and effectiveness of the products. Dietary supplements are not required to undergo government testing or review before they are marketed. Yet, supplements may have drug-like effects that could present risks for people on certain medicines or with certain medical conditions. This is true, even if the product is marketed as "natural." For example, St. John's Wort can have potentially dangerous interactions with a number of prescription drugs, including anticoagulants, oral contraceptives, antidepressants, anti-seizure medicines, drugs for HIV, and drugs to prevent transplant rejection.

If you take a prescription medicine, always consult your healthcare professional before starting a dietary supplement.

Some dietary supplement substances require further scrutiny and study before they can be considered safe for all people. Though many supplements have a history of use, that history does not necessarily guarantee safety in every circumstance.

Some substances for which safety concerns have been raised are comfrey, chaparral, lobelia, germander, aristolochia, ephedra (ma huang), L-tryptophan, germanium, magnolia-stephania, and stimulant laxative ingredients, such as those found in dieter's teas. The herb comfrey, for example, contains certain alkaloids that can cause serious liver damage. Consumers should not take any product containing comfrey either orally or as a suppository and should not apply comfrey products to broken skin.

Even some vitamins and minerals, when consumed in excessive quantities, can cause problems. For example, high intakes of vitamin A over a long period can reduce bone mineral density, cause birth defects and lead to liver damage, according to the National Academy of Sciences.

To ensure the safe use of any healthcare product, read the labels and package inserts, follow product directions and check with your healthcare professional.

How to Spot False Claims

When evaluating health-related claims, be skeptical. If something sounds too good to be true, it usually is. Here are some signs of a fraudulent claim:
· Statements that the product is a quick and effective cure-all or diagnostic tool for a wide variety of ailments. For example: "Extremely beneficial in the treatment of rheumatism, arthritis, infections, prostate problems, ulcers, cancer, heart trouble, hardening of the arteries and more."
· Statements that suggest the product can treat or cure diseases. For example: "shrinks tumors" or "cures impotency."
· Promotions that use words like "scientific breakthrough," "miraculous cure," "exclusive product," "secret ingredient" or "ancient remedy." For example: "A revolutionary innovation formulated by using proven principles of natural health-based medical science."
· Text that uses impressive-sounding terms like these for a weight-loss product: "hunger stimulation point" and "thermogenesis."
· Undocumented case histories or personal testimonials by consumers or doctors claiming amazing results. For example: "My husband has Alzheimer['s disease]. He began eating a teaspoonful of this product each day. And now in just 22 days he mowed the grass, cleaned out the garage, weeded the flower beds and we take our morning walk again."
· Limited availability and advance payment requirements. For example: "Hurry. This offer will not last. Send us a check now to reserve your supply."
· Promises of no-risk "money-back guarantees." For example: "If after 30 days you have not lost at least 4 pounds each week, your un-cashed check will be returned to you."

Avoiding Unscrupulous Dealers

It's easy to see why some people can be taken in by promoters' promises, especially when successful treatments have been elusive. But resist pressure to decide "on the spot" about trying an untested product or treatment. Ask for more information and consult a knowledgeable doctor, pharmacist or other healthcare professional. Promoters of legitimate healthcare products do not object to your seeking additional information.

To learn whether the FDA or the FTC have taken action against the promoter of a product you may be considering, visit www.fda.gov/oc/enforcement.html or www.ftc.gov. Visit www.cfsan.fda.gov/~dms/ds-warn.html for a list of the dietary supplement ingredients for which the FDA has issued warnings.

In addition, if you're considering a clinic that requires you to travel and stay far from home for treatment, check it out with your doctor. Although some clinics offer effective treatments, others prescribe untested, unapproved, ineffective, and possibly dangerous "cures." In addition, the healthcare providers who work in these clinics may be unlicensed or lack other appropriate credentials.

For information about a particular hospital, clinic or treatment center, contact the state or local health authorities where the facility is located. If the facility is in a foreign country, contact that government's health authority to see that the facility is properly licensed and equipped to handle the procedures involved. For information about facilities in Mexico, contact the Secretary of Health (Secretaria De Salud) in the Mexican state where the facility is located.

Online resources:

· Virtual Health "Treatments" (http://www.ftc.gov/bcp/conline/edcams/miracle/index.html)
Offers tips on avoiding health fraud online.

· Dietary Supplements (http://www.cfsan.fda.gov/~dms/supplmnt.html)
Offers an overview of dietary supplement regulation, including safety and warning information.

· Buying Medicines and Medical Products Online (http://www.fda.gov/oc/buyonline/default.htm)
Offers tips and precautions for buying medical products online.

How to Report a Potential Problem

To report a health product that you believe is being advertised falsely, contact:

· The FTC by phone, toll-free, at 1-877-FTC-HELP (1-877-382-4357); TDD: 202-326-2502; by mail to Consumer Response Center, Federal Trade Commission, Washington, DC 20580; or online at www.ftc.gov. Click on "File a Complaint Online."
· Your state Attorney General's office, state department of health, or local consumer protection agency. These offices are listed in the blue pages of your telephone book.

To report a product that you believe is fraudulently labeled, call your local FDA office. The number is listed in the blue pages of the telephone book.

To report an adverse reaction or illness that you think is related to the use of a supplement or other healthcare product, call a doctor or other healthcare provider immediately. You also may want to report your reaction or illness to FDA MedWatch. Call 1-800-FDA-1088 (1-800-332-1088) to request a report form, or file a complaint online at www.fda.gov/medwatch/report/hcp.htm. Patients' names are kept confidential. For more information on how to report a problem to FDA, see www.fda.gov/opacom/backgrounders/problem.html.

Food and Drug Administration

The FDA regulates over $1 trillion worth of products, which account for 25 cents of every dollar spent annually by American consumers. It is part of FDA's job to see that the food we eat is safe and wholesome and that the medicines and medical devices we use are safe and effective. For more information, call toll-free, 1-888-INFO-FDA (1-888-463-6332), or visit the FDA website, www.fda.gov.

Federal Trade Commission

The FTC works for the consumer to prevent fraudulent, deceptive and unfair business practices in the marketplace and to provide information to help consumers spot, stop, and avoid them. To file a complaint, or to get free information on any of 150 consumer topics, call toll-free, 1-877-FTC-HELP (1-877-382-4357), or use the online complaint form. The FTC enters Internet, telemarketing, identity theft and other fraud-related complaints into Consumer Sentinel, a secure, online database available to hundreds of civil and criminal law enforcement agencies US and abroad.

Source: Online at: http://www.ftc.gov/bcp/conline/pubs/health/frdheal.htm; September 2001.


FOLIC ACID REMINDER

Many physicians are missing a key opportunity to prevent birth defects by not telling their female patients to take a daily multivitamin containing folic acid, says the March of Dimes.

The voluntary health agency made its comments following the September 5th release of a survey of 2001 women aged 18 to 45 conducted by the Gallup Organization under a grant from the Centers for Disease Control and Prevention.

In the survey, 76 percent of the women said their physicians did not discuss the benefits of folic acid to prevent neural tube defects. Less than one-third of US women of childbearing age, not pregnant, take a daily multivitamin containing folic acid. But 20 percent of women asked said that they would be more likely to do so if physician or other health care professional said to.

The March of Dimes recommends that all women capable of becoming pregnant should take a multivitamin containing 400 µg of folic acid daily beginning before conception and continuing into the early months of pregnancy.

Copies of the survey, "Folic Acid and the Prevention of Birth Defects: A National Survey of Pre-Pregnancy Awareness and Behavior Among Women of Childbearing Age, 1995-2001," item 31-1596-01, may be obtained by calling (800) 367-6630.

Source: JAMA; 286(12); September 26, 2001; p. 1443.


IS FOLIC ACID FORTIFICATION PREVENTING NEURAL TUBE DEFECTS?

Neural tube defects (NTDs) are among the most common birth defects worldwide, resulting in nerve damage or death of the fetus due to spina bifida and anencephaly. Researchers have long known that folic acid supplementation of pregnant women can help reduce the incidence of NTDs, perhaps by as much as 50 percent to 70 percent, but translating this knowledge into effective public health policy has been problematic.

To prevent the first occurrence of a NTD, the U.S. Institute of Medicine recommends that women capable of becoming pregnant consume an extra 400 µg/d of synthetic folate, in addition to usual folate intake from foods. This approach recognizes that NTDs occur very early in a pregnancy, about the fourth week post-conception, and that women planning to become pregnant need extra folate at this very critical juncture. However, because an estimated 50 percent of pregnancies are not planned, and unplanned pregnancies usually have not been confirmed by the fourth week of gestation, in many cases a NTD will already have occurred by the time the pregnant woman thinks to begin folic acid supplementation(1). Therefore, pregnancy cannot be used as the trigger to initiate supplementation.

Focus on Fortification

The solution to this problem, according to many experts, is population-wide folic acid supplementation through food fortification. In 1998, the U.S. Food and Drug Administration endorsed this view by mandating folic acid fortification of all enriched grain products at a level of 140 µg per 100 g of product. This quantity is not sufficient to produce the full 400 µg/d of supplementation that is recommended for pregnant women, but this reduced level of fortification was deliberately chosen to prevent over consumption of folic acid by those who eat large quantities of fortified products. Of particular concern is that widespread fortification could mask pernicious anemia in the elderly, thereby delaying treatment of vitamin B12 deficiency.

Although it is understandable that the FDA would want to err on the conservative side, there has been some question as to whether fortification at these levels will help prevent NTDs. A national panel from the UK recently recommended that flour be fortified with folic acid at 240 µg per 100 g of product, nearly twice the level now mandated in the United States (2). It concluded that fortification at these levels could produce a significant reduction in NTDs without resulting in over consumption by any population segment.

Birth Certificate Data Show NTD Reductions

So, is the more cautious United States' approach to fortification working? According to two recent studies, the answer appears to be yes.
In a poster presented at the American College of Obstetricians and Gynecologists meeting in May 2001, Mark Evans and colleagues from Hahnemann University reported on their assessment of maternal serum alpha-fetoprotein (MSAFP) values in a total of 61,119 pregnant women in 1997 (before the U.S. fortification program began) and again in 2000 (3). Results show a 42 percent decrease in the number of patients with a multiple of median MSAFP value of 3.00 of higher. Given that higher MSAFP values are associated with increased likelihood of NTDs, Evans et al. concluded that this profound decrease would likely reflect a reduction in the number of actual births affected by NTDs.

This conclusion now appears to be confirmed by outcomes data from live births. Using birth certificate reports of NTDs from 45 states and Washington DC, Honein and colleagues compared the prevalence of spina bifida and anencephaly before mandatory folic acid fortification began (October 1995 through December 1996) to that after the program was in place (October 1998 through December 1999). Their findings indicate that NTDs decreased from 37.8 per 100,000 live births to 30.5 per 100,000 births, a decline of 19 percent (4).

The authors note that the quality of data obtained from birth certificates is limited, both because of known reporting inaccuracies and because many women with NTD-affected pregnancies choose to terminate their pregnancies. Still, according to other expert investigators, the data are robust enough to allow for some critical conclusions to be made. "The study by Honein et al. provides important information, food fortification works," write Mills and England in an accompanying editorial. "Birth certificates data can, however, provide only imprecise estimates of how well it works. Much hard work lies ahead to determine how many cases of NTD are actually being prevented" (5). They say that additional studies will be needed to decided whether folic acid fortification should continue at present levels, or if it should be increased, as some suggest, to reap even greater public health benefits.

Why Do Supplements Work?

Although these results appear to indicate significant progress in preventing NTDs, it can be argued that we have made little headway in the past decade in understanding why folic acid supplementation reduces NTD risk. Researchers agree that clinical folate deficiency is not a major cause of NTDs. There is some evidence to suggest that folate absorption is impaired in pregnancies affected by NTD, but these studies have been difficult to interpret because of differing methodologies.

Recently, using a new a more precise stable isotope tracer technique, Boddie and colleagues assessed whether 11 women with a history of NTD had reduced ability compared with 11 control group women to absorb polyglutamyl folate (the form of folate found naturally in foods) and monoglutamyl folate (synthetic folic acid found in supplements or fortified foods) (6). They found no significant difference in the ability of either group to absorb (estimated by urinary excretion) food folate vs. folic acid. However, the women with previous NTD-affected pregnancies showed a trend toward lower absorption of both forms of folate compared to control women. According to the authors, "The magnitude of this potential difference appears to be in the range of 20-25 percent, which may result in a physiologically significant difference in folate status in situations in which intake is limited." Larger studies using the same technique are needed to confirm these findings.

References:

1. McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM. Response of red blood cell folate to intervention: implications for folate recommendations for the prevention of neural tube defects. Am J Clin Nutr; May 2000;71 (5 Suppl):1308S-11S. Review.
2. Kirby RS. Fortification of foods with folic acid. N Engl J Med; September 28, 2000;343(13):971; discussion 972.
3. Evans MI, Wapner RJ, O'Brien JE, Dvorin E, Huang X, Harrison H. Impact of folic acid supplementation in the United States: markedly diminished high maternal serum AFPs. Obstet Gynecol; April 2001;97(4 Suppl 1):S42.
4. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA; 2001 Jun 20;285(23):2981-6.
5. Mills JL, England L. Food fortification to prevent neural tube defects: is it working? JAMA; June 2001 20;285(23):3022-3..
6. Boddie AM, Dedlow ER, Nackashi JA, Opalko FJ, Kauwell GP, Gregory JF 3rd, Bailey LB. Folate absorption in women with a history of neural tube defect-affected pregnancy. Am J Clin Nutr; July 2000; 72(1): 154-8.

Source: Nutrition & the MD; 27(8); August 2001; pp.4-5.

 

ALTERNATIVE MEDICINE IS NO FAD

Complementary and alternative medicine (CAM) is not a passing fad and will be around for the foreseeable future, said Harvard Medical School researchers in a study published in the August 21 Annals of Internal Medicine (1).

The study used data compiled from more than 2000 interviews and examined trends in the use of 20 different types of CAM from acupuncture to yoga.
The use of alternative treatments was independent of gender, ethnicity, and education level. Regional trends and urban vs rural differences were also absent. The researchers said most of the 20 therapies have steadily increased in popularity since the 1960s, with the largest overall growth rate occurring in the late 1960s and early 1970s.

The researchers noted the timing of societal adoption of particular therapies. In the 1960s, commercial diet programs, lifestyle diet therapy, megavitamin therapy, and self-help groups increased markedly. The 1970s saw growth in biofeedback, energy healing, herbal medicine, and imagery. In the 1980s, massage and naturopathy increased while yoga decreased in popularity. The 1990s brought increased use of aromatherapy, energy healing, herbal medicine, massage, and yoga.

Reference:

1. Goldman P. Herbal medicines today and the roots of modern pharmacology. Ann Intern Med. 2001 Oct 16;135(8 Pt 1):594-600.

Source: JAMA; 286(12); September 26, 2001; p. 1443.

SOY FOODS: SHOULD YOU OR SHOULDN'T YOU?

For years now, research has suggested that soy may be an effective cancer-fighter. But some recent studies suggest that women at high risk for breast cancer should moderate their soy intake. The current consensus is that you don't have to give up your tofu stir-fry or soy shake, but you may want to hold off on taking soy supplements.

It's been a long, strange trip for the humble soybean. A central part of Asian diets for millennia, this pale brown legume spent many years dismissed by meat-loving Americans as a strange "hippie" food. Gradually, however, soy has assumed a place in the scientific spotlight. In just the last few years, a realistic picture has emerged of soy's proper place in healthy, disease-fighting diets.

The Early Days of Soy Research

Cancer researchers began studying soy in an effort to explain why women in Asian countries had far fewer cases of breast cancer than American women. Interestingly, when Asian women moved to countries that consume more "Western" diets, higher in fat, lower in vegetables, and particularly low in soy foods like tofu and miso, their rates of breast cancer increased within one generation.

Before long, laboratory work began to support soy's potential for fighting cancers of the breast, prostate and colon. In some early trials, soy showed the ability to inhibit biological activities associated with these cancers in human subjects as well. Scientists soon came to focus on specific substances in soy called isoflavones. Recent research on soy isoflavones, however, has shown mixed results.

Are Soy Isoflavones Helpful or Harmful?

According to current theories, isoflavones are natural substances in soy that (among other functions) seem to act as weak forms of estrogen. That's important because some forms of breast cancer use estrogen to "feed" the formation of tumors. When soy isoflavones "stand in" for estrogen, breast cells obtain less of this powerful hormone, and are less likely to produce tumors.

So far so good, but a few recent studies have signaled that isoflavones may produce some negative effects as well. In one much-discussed clinical trial, supplements of soy isoflavones were found to increase the rate at which breast cells reproduce. That's worrisome because if a mutation should occur while cells are quickly growing and dividing, the cancer process could theoretically get off to a rapid start.

Researchers are quick to point out, however, that the results of any individual study need to be viewed in their proper context. This particular trial involved isoflavone supplements, not soy foods, and it lasted only two weeks. In addition, increased cell growth is just one of several indicators for breast cancer risk.

The Bottom Line

Since there aren't yet any dietary recommendations for soy intake and cancer prevention, what can we conclude? Dr. Mark Messina, a prominent soy foods expert at Loma Linda University in California, acknowledges that recent studies raise important questions. He believes that common sense and moderation offer the best answers.

Dr. Messina urges people to start by considering the Asian example. Most Japanese, for instance, consume no more than a single serving of soy food a day. "Loading up on any one food, including soy, is not advisable," he says. "A balanced diet that includes soy is a good idea, as long as it also includes plenty of vegetables, fruits, whole grains and beans. After all, many different plant foods appear to provide health benefits. The best way to take advantage of that fact is to eat a wide variety, all the time."

Many soy researchers believe that, for healthy women, even two of three servings of soy foods a day should be fine as one part of a mostly plant-based diet. Women at high risk for breast cancer, women who are taking tamoxifen, and women who have of have had hormone-dependent (estrogen-positive of ER+) breast cancer may want to limit themselves to no more than a few servings a week.

As for soy supplements, watch out. Soy pills and powders can contain amounts of isoflavones (usually daidzein and genistein) far in excess of the amounts possible to get through diet. Very little research has been done on the effects of such "mega-doses." The research that has been done raises enough doubt to conclude that, for the time being, it's probably best to leave the soy supplements on the store shelf.

Source: AICR Newsletter; Fall 2001; 73:1-3.


RESOURCES:

PRENATAL & INFANT NUTRITION FOR TEENS

"Building for the Future" is a nutrition education program curriculum designed to help teach the basics of prenatal and infant/young child nutrition to pregnant and parenting teens. The CD-ROM contains PowerPoint slide shows, Microsoft Word pre-tests, handouts, worksheets and post-tests for classroom instruction. It is produced by Outreach & Extension at the University of Missouri Lincoln University. For more information call 1-800-292-0969 or order at: http://www.muextension.missouri.edu/xplor/order.htm

Source: University of Missouri Press Release; August 01, 2001.

NUTRITION/PHYSICAL RESOURCES ON THE WEB

Knowledge Path: Childhood Nutrition

The National Center for Education in Maternal and Child Health (NCEMCH) has updated the knowledge path on childhood nutrition. This electronic document offers a guide to the Center's Web site on the topic and selected electronic and print resources found elsewhere. Identified in the knowledge path are downloadable electronic publications, databases, project descriptions, electronic discussion lists, and Web sites. Betsy Haughton at University of Tennessee and Jan Dodds at University of North Carolina at Chapel Hill assisted in the development process and provided content review.

Go to http://www.ncemch.org/RefDes/kpchildnutr.html

Bright Futures in Practice: Physical Activity

The NCEMCH posted an electronic version of Bright Futures in Practice: Physical Activity on the Bright Futures Web site. The guide provides current information on screening, assessment, and counseling to promote physical activity and to meet the needs of health professionals, families, and communities. The project was co-chaired by Kevin Patrick at San Diego State University and Bonnie Spear at University of Alabama at Birmingham and supported by MCHB/HRSA. Go to http://www.brightfutures.org/physicalactivity

The NCEMCH's nutrition and physical activity projects are supported by the Maternal and Child Health Bureau of the Health Resources and Services Administration through a cooperative agreement.

Source: NCEMCH Press Release; September 07, 2001.

HHS MEDIA ADVISORY

HHS Deputy Secretary Claude Allen unveiled Healthfinder Espanol, a new, Spanish-language gateway to reliable health information, at the Mary's Center for Maternal and Child Care, on September 28.

Healthfinder Espanol will help Spanish-speaking individuals easily find the answers to their health-related questions. Healthfinder is the award-winning, federal consumer health portal Web site managed by the US Department of Health and Human Services (HHS).

The HHS Office of Disease Prevention and Health Promotion, which leads the Healthfinder project, has worked with patients, staff, and local community members at Mary's Center, teaching citizens how to use the Internet as well as the Healthfinder Web site. Input received from the Mary's Center community was vital in the creation of Healthfinder Espanol. All HHS press releases, fact sheets and other press materials are available at www.hhs.gov/news.

Source: HHS Press Release; September 25, 2001.

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