Susan J. Zunino, Ph.D.

 Susan J. Zunino, Ph.D.

Position

  • Adjunct Professor
  • Department of Nutrition
  • Research Molecular Biologist
  • USDA ARS Western Human Nutrition Research Center

Contact

Education

  • B.S., Biology, University of Nevada, Reno
  • Ph.D., Cellular and Molecular Biology, University of Nevada, Reno

Research Interests

Dr. Zunino’s lab is interested in how phytochemicals regulate immune response.  Obesity increases the risk of developing viral and bacterial infections compared to normal weight individuals.  The focus of the laboratory is to understand how dietary phytochemicals may modulate the innate immune response to decrease the risk of infection in the obese. 

Selected Publications

Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, Bonnel EL, Woodhouse LR, Zunino SJ, Peerson JM, Lee JY, Rutledge JC, Hwang DH. Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial. J Nutr. 2016 Jul;146(7):1411-9. [PubMed]

Zunino SJ, Storms DH, Freytag TL, Adkins YC, Bonnel EL, Woodhouse LR, Breksa AP 3rd, Manners GD, Mackey BE, Kelley DS. Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults. Nutr Res. 2016 Jan;36(1):24-30. [PubMed]

Zunino SJ, Storms DH. Physiological levels of resveratrol metabolites are ineffective as anti-leukemia agents against Jurkat leukemia cells. Nutr Cancer 2015;67(2):266-74. [PubMed]

Zunino SJ, Peerson JM, Freytag TL, Breksa AP, Bonnel EL, Woodhouse LR, Storms DH. Dietary grape powder increases IL-1beta and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans. Br J Nutr 2014;112(3):369-80. [PubMed]

Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. Int J Oncol 2013;42(2):741-8. [PubMed]

Zunino SJ, Storms DH, Freytag TL, Mackey BE, Zhao L, Gouffon JS, Hwang DH. Dietary strawberries increase the proliferative response of CD3/CD28-activated CD8(+) T cells and the production of TNF-alpha in lipopolysaccharide-stimulated monocytes from obese human subjects. Br J Nutr 2013;110(11):2011-9. [PubMed]

Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol 2012;40(4):1277-84. [PubMed]

Zunino SJ, Storms DH, Newman JW, Pedersen TL, Keen CL, Ducore JM. Dietary resveratrol does not delay engraftment, sensitize to vincristine or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice. Int J Oncol 2012;41(6):2207-12. [PubMed]

Zunino SJ, Parelman MA, Freytag TL, Stephensen CB, Kelley DS, Mackey BE, Woodhouse LR, Bonnel EL. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr 2012;108(5):900-9. [PubMed]

Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ. Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice. Br J Nutr 2012;108(10):1789-99. [PubMed]

Zunino SJ, Storms DH, Ducore JM. Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11). Cancer Lett 2010;296(1):49-54. [PubMed]

Zunino SJ, Storms DH, Ducore JM. Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11). Int J Oncol 2010;37(5):1307-13. [PubMed]

Zunino SJ, Storms DH. Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells. Nutr Cancer 2009;61(1):94-102. [PubMed]

Zunino SJ, Storms DH. Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro. J Nutr 2009;139(8):1603-8. [PubMed]

Zunino SJ, Storms DH, Stephensen CB. Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. J Nutr 2007;137(5):1216-21. [PubMed]

Zunino SJ, Ducore JM, Storms DH. Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells. Cancer Lett 2007;254(1):119-27. [PubMed]

Zunino SJ, Storms DH. Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. Cancer Lett 2006;240(1):123-34. [PubMed]

Peipp, M., D. Saul, K. Barbin, J. Bruenke, S.J. Zunino, M. Niederweis, and G.H. Fey. 2004. Efficient secretion of fluorescent scFv-fusion proteins directed against CD antigens from insect and mammalian cells. J. Immunol. Methods 285: 265-280. [PubMed]

Bruenke, J., B. Fischer, K. Barbin, K. Schreiter, Y. Wachter, K. Mahr, F. Titgemeyer, M. Peipp, S.J. Zunino, R. Repp, T. Valerius, and G.H. Fey. 2004. A recombinant bispecific single-chain Fv antibody against HLA class II and Fc RIII (CD16) triggers effective lysis of lymphoma cells. Br. J. Haematol. 125: 167-179. [PubMed]

Lang, P., K. Barbin, T. Feuchtinger, J. Greil, M. Peipp, S.J. Zunino, M. Pfeiffer, R. Handgretinger, D. Niethammer, G.H. Fey. 2004. Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts. Blood 103: 3982-3985. [PubMed]

Kellner, C. and S.J. Zunino. 2004. Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization. Cancer Lett., in press. [PubMed]

Knott, A., Y. Mueller, S.J. Zunino, C. Berens, and W. Hillen. 2003. Conditional cell suicide using dox-dependent caspase-2 expression. J. Gene Med. 5: 343-354. [PubMed]

Dörrie, J., K. Sapala, and S.J. Zunino. 2002. Interferon-g increases the expression of glycosylated CD95 in B-leukemic cells: An inducible model to study the role of glycosylation in CD95-signaling and trafficking. Cytokine 18: 98-107. [PubMed]

Peipp, M., H. Küpers, D. Saul, B. Schlierf, J. Greil, S.J. Zunino, M. Gramatzki, and G.H. Fey. 2002. A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells. Cancer Res. 62: 2848-2855. [PubMed]

Dörrie, J., K. Sapala, and S.J. Zunino. 2001. Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett. 170: 33-39. [PubMed]

Dörrie, J., H. Gerauer, Y. Wachter, and S.J. Zunino. 2001. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61: 4731-4739. [PubMed]

Peipp, M., N. Simon, A. Loichinger, W. Baum, K. Mahr, S.J. Zunino, and G. H. Fey. 2001. An improved procedure for the generation of recombinant single-chain Fv antibody fragments reacting with human CD13 on intact cells. J. Immunol. Methods 251: 161-176. [PubMed]

Dörrie, J., W. Schuh, A. Keil, E. Bongards, J. Greil, G.H. Fey, and S.J. Zunino. 1999. Regulation of CD95 expression and CD95-mediated cell death by interferon-g in acute lymphoblastic leukemia with chromosomal translocation t(4;11). Leukemia 13: 1539-1547. [PubMed]

Zunino, S.J., J. Bass, M. Singh, and L.J. Picker. 1996. Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes. Am. J. Pathol. 149(2): 653-663. [PubMed]

Zunino, S.J., L.F. Simons, J.F. Sambrook, and M.J.H. Gething. 1994. Interleukin-1 promotes hyperglycemia and insulitis in mice normally resistant to streptozotocin-induced diabetes. Am. J. Pathol. 145(3): 661-670. [PubMed]

Hudig, D., N.J. Allison, G.R. Ewoldt, R. Gault, D. Netski, T.M. Pickett, D.D. Redelman, M.T. Wang, U. Winkler, S.J. Zunino, C.-M. Kam, S. Odake, and J.C. Powers. 1993. Serine protease control of lymphocyte-mediated cytolysis. In Cytotoxic Cells: Generation, Recognition, Effector Functions and Methods. M.V. Sitkovsky and P.A. Henkart (eds.), Springer Verlag, Boston, pp 295-304.

Gething, M.J.H., L. Roman, L. Simons, S. Zunino, N. Jiang, R. Hammer, and J. Sambrook. 1991. Transgenic animal models in biomedical research. Proceedings National Institute of Health Symposium, Washington, D.C. (November 4-5), D.G. Scarpelli, G. Migaki, and J.M. Pletcher (eds.), pp 43-46.

Zunino, S.J., R.C. Bleackley, J. Martinez, and D. Hudig. 1990. RNKP-1, a novel NK-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes. J. Immunol. 144: 2001-2009. [PubMed]

Zunino, S.J., N.J. Allison, C.-M. Kam, J.C. Powers, and D. Hudig. 1988. Localization, function, and gene expression of chymotrypsin-like proteases of cytotoxic RNK-16 lymphocytes. Biochim. Biophys. Acta 967: 331-340. [PubMed]

Zunino, S.J. and D. Hudig. 1988. Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562. Infect. Immun. 56(3): 564-569. [PubMed]