Gertrud Schuster, Ph.D.

 Gertrud  Schuster, Ph.D.

Position

  • Associate Project Scientist
  • Department of Nutrition

Contact

Education

  • MS (Diploma) in Biomedicine (Human Biology), Philipps-University at Marburg, Germany
  • Ph.D., Technical University Munich, Germany

Research Interests

Dr Schuster is investigating the effects of several nutrients, among them vitamin A and/ or D, omega-3/omega-6 fatty acids on bone metabolism, endocrine and immune function. Her research focusses on metabolic profiling of fatty acids and inflammatory bio-markers in combination with genetic predispositions/ polymorphisms. This will be examined in human intervention trials, in corresponding mouse models of inflammation, and in in-vitro assays.

Selected Publications

Schuster GU, Bratt JM, Jiang X, Pedersen TL, Grapov D, Adkins Y, Kelley DS, Newman JW, Kenyon NJ, Stephensen CB. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. Am J Respir Cell Mol Biol 2014;50(3):626-36. [PubMed]

O'Sullivan A, Armstrong P, Schuster GU, Pedersen TL, Allayee H, Stephensen CB, Newman JW. Habitual diets rich in dark-green vegetables are associated with an increased response to omega-3 fatty acid supplementation in Americans of African ancestry. J Nutr 2014;144(2):123-31.[PubMed]

Linderholm AL, Bratt JM, Schuster GU, Zeki AA, Kenyon NJ. Novel therapeutic strategies for adult obese asthmatics. Immunol Allergy Clin North Am 2014;34(4):809-23.[PubMed]

Labouesse MA, Gertz ER, Piccolo BD, Souza EC, Schuster GU, Witbracht MG, Woodhouse LR, Adams SH, Keim NL, Van Loan MD. Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone loss. Bone 2014;64:138-46.[PubMed]

Stephensen CB, Armstrong P, Newman JW, Pedersen TL, Legault J, Schuster GU, Kelley D, Vikman S, Hartiala J, Nassir R, Seldin MF, Allayee H. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res 2011;52(5):991-1003.[PubMed]

Schuster GU, Kenyon NJ, Stephensen CB. Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol 2008;180(3):1834-42.[PubMed]

Schuster GU, Johansson L, Kietz S, Stulnig TM, Parini P, Gustafsson JA. Improved metabolic control by depletion of Liver X Receptors in mice. Biochem Biophys Res Commun 2006;348(1):176-82.[PubMed]

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P. Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol Pharmacol 2006;70(4):1340-9.[PubMed]

Robertson KM, Schuster GU, Steffensen KR, Hovatta O, Meaney S, Hultenby K, Johansson LC, Svechnikov K, Soder O, Gustafsson JA. The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology 2005;146(6):2519-30.[PubMed]

Rasooly R, Schuster GU, Gregg JP, Xiao JH, Chandraratna RA, Stephensen CB. Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. J Immunol 2005;175(12):7916-29.[PubMed]

Gnerre C, Schuster GU, Roth A, Handschin C, Johansson L, Looser R, Parini P, Podvinec M, Robertsson K, Gustafsson JA, Meyer UA. LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. J Lipid Res 2005;46(8):1633-42.[PubMed]

Toresson G, Schuster GU, Steffensen KR, Bengtsson M, Ljunggren J, Dahlman-Wright K, Gustafsson JA. Purification of functional full-length liver X receptor beta produced in Escherichia coli. Protein Expr Purif 2004;35(2):190-8.[PubMed]

Steffensen KR, Neo SY, Stulnig TM, Vega VB, Rahman SS, Schuster GU, Gustafsson JA, Liu ET. Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals. J Mol Endocrinol 2004;33(3):609-22.[PubMed]

Steffensen, K. R., Nilsson, M., Schuster, G.U., Stulnig, T.M., Dahlman-Wright, K. and Gustafsson J. Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of Liver X Receptors alpha and beta respectively. Biochem. Biophys. Res. Commun. 2003;310:589-593. [PubMed]

Antonson, P., Schuster, G.U., Wang, L., Rozell, B., Holter, E., Flodby, P., Treuter, E., Holmgren, L. and Gustafsson J. Inactivation of the nuclear receptor coactivator RAP 250 in mice results in placental vascular dysfunction. Mol. Cell. Biol., 2003;23:1260-1268. [PubMed]

Juvet, L.K., Andresen, S.M., Schuster, G.U., Dalen, K.T., Tobin, K.A.R., Hollung, K., Haugen, F., Jacinto, S., Ulven, S. M., Bamberg, K., Gustafsson, J.Å. and Nebb, H.I. On the role of LXR-alpha in lipid accumulation in adipocytes. Mol Endo, 2002;17:172-182. [PubMed]

Schuster, G.U., Parini, P., Wang, L., Alberti, S., Steffensen, K.R., Hansson, G.K., Angelin, B. and Gustafsson, J. Accumulation of foam cells in LXR-deficient mice. Circulation, 2002;106:1147-53. [PubMed]

Wang, L., Schuster, G.U., Hultenby, K., Zhang, Q., Andersson, S. and Gustafsson, J. Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration.Proc Natl Acad Sci U.S.A., 2002;99:13878-13883. [PubMed]

Stulnig T.M., Oppermann, U., Steffensen, K.R., Schuster, G.U. and Gustafsson, J. Liver X Receptors downregulate 11b-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes, 2002;51:2426-33. [PubMed]

Stulnig, T.M., Steffensen, K.R., Gao, H., Reimers, M., Dahlman-Wright, K., Schuster, G.U. and Gustafsson, J. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol. 2002;62:1299-1305. [PubMed]

Li-Hawkins, J., Gåvels, M., Olin, M., Lund, E.G., Andersson, U., Schuster, G.U., Björkhem, I., Russell, D.W. and Eggertsen, G. Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J. Clin. Invest. 2002;110:1191-1200. [PubMed]

Steffensen, K.R., Schuster, G.U., Parini, P., Holter, E., Sadek, C.M., Cassel, T., Eskild, W. and Gustafsson, J. Different regulation of the LXRa promoter activity by isoforms of CCAAT/enhancer-binding proteins. Biochem. Biophys. Res. Commun. 2002; 293:1333-1340. [PubMed]

Tobin, K.A.R., Ulven, S.M., Schuster, G.U., Steineger, H.H., Andresen, S.M., Gustafsson, J. and Nebb, H.I. LXRs as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem., 2002, 277, 10691-10697. [PubMed]

Alberti, S., Schuster, G.U., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S. and Gustafsson, J. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRb-deficient mice. J. Clin. Invest, 2001, 107, 565-573. [PubMed]

Peters, H., Schuster, G.U., Neubüser, A., Richter, T., Höfler, H. and Balling, R. Isolation of the PAX9 cDNA from adult human esophagus. Mamm. Genome, 1997, 8, 62-64. [PubMed]

Löffler, M., Jöckel, J., Schuster G.U. and Becker C. Dihydroorotate: ubiquinone oxidoreductasse links mitochondria in the biosynthesis of pyrimidine nucleotides.Mol. Cell Biochem. 1997, 174, 125-129. [PubMed]

Löffler, M., Becker, C., Wegerle E. and Schuster G.U. Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/ oxidase and succinat dehydrogenase in mammalian tissues, cells and mitochondria. Histochem. Cell Biol., 1996, 105, 119-128. [PubMed]

Löffler, M., Rotgeri, A., Becker, C., Lakaschus, G. and Schuster, G.U. Dihydroorotate dehydrogenase from rat liver: localization, characterization and sequencing cDNA clones. German Journal of Gastroenterology, 1994, 32, 53.

Knecht, W., Altekruse, D., Schuster, G.U., Günnewig, K. and Löffler, M. Investigation of Mammalian Dihydroorotate-Dehydrogenase: Topochemical Relation to the Respiratory Chain. Biol Chem Hoppe Seyler, 1994, 375, 64.