MATHEMATICAL MODELING IN EXPERIMENTAL NUTRITION

Introduction

A healthful diet is key to growth, development, reproduction and disease prevention because it optimizes the dynamics of nutrient metabolism. There is keen interest in modeling of kinetic data to understand the dynamics of nutrient metabolism in vivo. Availability of tagged nutrients, novel analytical methods and computers that can solve/manipulate differential equations efficiently and accurately allows the dynamics of nutrient metabolism to be modeled.

Modeling is an important partner of experimental work. Opportunities now exist to characterize the dynamics of nutrient metabolism in vivo in humans at an unparalleled level of detail. Organizing and interpreting this detail will lead to a more fundamental understanding of diet and health, the dynamics of nutrient metabolism, the factors that affect it and the health consequences of altering it. An enhanced cooperative effort to emphasize modeling will provide new conceptual frameworks for experimentalists and attract scientists with diverse talents to study nutrition problems.

The conference includes 26 lectures by speakers that constitute an internationally renowned and diverse group of scholars. Presentations will be 40 to 45 minutes long followed by 10 to 15 minutes for discussion and questions. Abstracts of papers to be presented are available.

The lecture room (55 Roessler) will be equipped with a projector for 2x2 slides, an overhead projector for transparencies and a projection pallet for a lap-top computer.

Several Pentium computers loaded with SAAM and ACSL will be available for the modeling workshops in 1136 Meyer. Additional Pentium computers loaded with SAAM II will be available in 1138 Meyer Hall. Several poster boards are available in 1105 Meyer Hall for those wishing to display posters.

Three units of graduate credit are available to graduate students attending the conference. The Fall Quarter CRN for the Modeling course (NUT 298-05) is 68488. It has been set up as a letter-grade course. Everyone who is going to enroll must do so for 3 units.

Conference Program

Sunday (August 17) (Abstracts)
8:45-9:15	Registration (*Roessler Hall*)
9:15-10:00	Introduction Kevin Smith^1,Janet King², John Vogel^3.University of California¹, Davis, USDA/WHNRC², LLNL³.
Background & Theoretical Considerations for Compartmental Modeling. Chair: Michael Green
10:00-11:00	*"Balancing Needs, Efficiency, and Functionality in the Provision of Modeling Software:* *A Perspective* of *the NIH WinSAAM Project "* Ray Boston¹, Peter Greif², Meryl Wastney³, and Oscar Linares⁴. Clinical Studies¹, NBC, University of Pennsylvania; Laboratory of Experimental and Computational Biology² , National Institutes of Health; Dept. of Neonatology³, Georgetown University Medical School; and Department of Geriatrics⁴, Medical School, University of Michigan.
11:00-12:00	*"Approaches to Compartmental Population Kinetics."* Paolo Vicini¹, Bradley M. Bell², Claudio Cobelli³ , David M. Foster¹, Alan Schumitzky⁴ and P. Hugh R. Barrett¹. Department of Bioengineering¹, University of Washington, Seattle, WA; Applied Physics Laboratory², University of Washington, Seattle, WA; Department of Electronics and Information³, University of Padova, Italy; and Department of Mathematics⁴, University of Southern California, Los Angeles, CA
12:00-1:30	Lunch (Tercero Dining Commons)
(Chair: David Giltinan)
1:30-2:30	*"Statistical Models for Quantitative Bioassay.*" Matthew R. Facer¹, Hans-Georg Mueller¹, Andrew J. Clifford². Division of Statistics¹ and Dept of Nutrition², University of California, Davis, CA.
2:30-2:45	Break
2:45-3:45	*"The Mathematics Behind Modeling.* " Judah Rosenblatt, Metabolism Unit Shriners Burns Institute, Director of Biomathematics, University of Texas Medical Branch, Galveston, TX.
3:45-4:45	*"Nonparametric Calibration."* Raymond J. Carroll, Statistics Department, Texas A&M University, College Station, TX.
5:00-6:30	Barbecue Dinner & Mixer (*Leach Hall Courtyard) Menu*
Practical Examples of Compartmental Modeling for Beginning Modelers (Chair: Stephen Coburn)
7:00-8:00	*"Modeling Lactation with SAAM.*" Janet A. Novotny, USDA, Human Performance Laboratory, BHNRC, Beltsville, MD.
8:00-9:00	*"Modeling Energy Metabolism with ACSL.*" Heidi Johnson, Animal Science Department, University of California, Davis, CA.
Plenary Lecture For Experienced And Beginning Modelers.
9:00-10:00	*"Necessity for Modeling: Using the Accessible to Predict the Inaccessible. "* Claudio Cobelli, Department of Electronics and Informatics, University of Padova, Padua, Italy

Monday (August 18) Location: *55 Roessler* (Abstracts)
Modeling in Design of Experiments in Vitamin and Mineral Metabolism. (Chair: Harold Furr)
8:00-9:00	*"Modeling the Dynamics of Vitamin A Metabolism in Men.* " Michael H. Green¹ & Doris von Reinersdorff². Pennsylvania State University¹, University Park, PA; and Hoffmann-La Roche², Basel, Switzerland and Nutley, NJ.
9:00-10:00	*"Modeling of Vitamin A and beta-Carotene in Humans."* Betty J. Burri & Jin-Young Kim Park, Western Human Nutrition Research Ctr, USDA, Presidio of San Francisco, CA.
10:00-10:15	Break
10:15-11:15	"The Dynamics of Folate Metabolism in an Adult Volunteer" Andrew J. Clifford¹, Ali Arjomand¹, Stephen R. Dueker¹, Heidi Johnson², A. Daniel Jones³, Philip D. Schneider⁴ , Rebecca A. Zulim⁴ , Bruce Buchholz⁵ & John S. Vogel⁵. Nutrition¹ and Animal Science² Departments and Facility for Advanced Instrumentation³, University of California, Davis, CA, Cancer Center⁴, UCDMC, Sacramento, CA; and Center for Accelerator Mass Spectroscopy⁵, Lawrence Livermore National Laboratory, Livermore, CA.
Chair: Janet King
11:15-12:15	*"Human Zinc Metabolism: Advances in the Modeling of Stable Isotope Data."* K. Michael Hambidge, Nancy F. Krebs & Leland V. Miller, Univ. of Colorado Ctr for Human Nutrition, Denver, CO.
12:30-1:30	Lunch (*Tercero Dining Commons*)
1:30-2:30	*"Key Features of Copper Versus Molybdenum Metabolism in Humans Identified by* *Modeling."* Judith R. Turnlund, Western Human Nutrition Research Center, USDA, Presidio of San Francisco, CA.
2:30-3:30	*"Realistic Models of Calcium Waves in Living Cells.* " John Wagner¹, Richard L. Nuccitelli² & Joel E. Keizer³. Institute and Graduate Group in Applied Mathematics¹, and Sections of Molecular and Cell Biology² & Neurobiology, Physiology and Behavior³, Division of Biologic Sciences, University of California, Davis, CA.
3:30-3:45	Break
3:45-4:45	*"Calcium Kinetics During Extended Space Flight."* Meryl E. Wastney¹, Scott M. Smith²,Victor S. Oganov³ , Boris V. Morukov³, Irina M. Larina³, Steven A. Abrams⁴, Laurence E. Nyquist², Chi-Yu Shih², and Helen W. Lane². Georgetown University Medical Center¹, Washington, DC; NASA Johnson Space Center², Houston, TX; Institute for Biomedical Problems³, Moscow, Russia; and Baylor College of Medicine⁴, Houston, TX.
4:45-5:45	*"Insights into Bone Metabolism from Calcium Kinetic Studies in Children."* Steven A. Abrams, USDA, Childrens Nutrition Research Center, Houston, TX.
6:00-7:30	Dinner (*Tercero Dining Commons*)

ALL DAY	Modeling Workshops / Practice / Posters
	Ray C. Boston, Clinical Studies Dept, NBC, University of Penn. School of Veterinary Med, Kenneth Square, PA. Stephen P. Coburn, Biochemistry Department, Fort Wayne State Development Center, Fort Wayne, IN. David M. Foster, Center for Bioengineering, University of Washington, Seattle, WA. Michael H. Green, Nutrition Department, Pennsylvania State University, University Park, PA.

Tuesday (August 19)
Location:
8:00 am - 10:00 am Temporary Classroom 3, 10:15 a.m. - 6:00 p.m. 55 Roessler
(Abstracts)

Compartmental Modeling of Energy Metabolism, Protein, Growth, Lactation, and Amino Acids
(Chair: Chris Calvert)

Location: Temporary Classroom 3

8:00-9:00

"Modeling Ruminant Digestion and Metabolism."
Ransom L. Baldwin, Animal Science Department, University of California, Davis.

9:00-10:00

"Development and Application of a Compartmental Model of 3-Methylhistidine Metabolism in Humans and Domestic Animals."
John A. Rathmacher, Metabolic Technologies, Inc., and Animal Science Department, Iowa State University, Ames, IA.

10:00-10:15

Break

Location: 55 Roessler

10:15-11:15

"A Theoretical Model of Protein Synthesis and Degradation to Identify Appropriate Experimental Designs."
Heidi Johnson, Chris Calvert, Ransom L. Baldwin. Animal Science Department, University of California, Davis, CA.

11:15-12:15

"Dynamics of Glucose and Lipid Metabolism Using Mass Isotopomer Distribution Analysis (MIDA)."
Marc K. Hellerstein, Nutritional Sciences Dept. University of California, Berkeley, CA.

12:30-1:30

Lunch (Tercero Dining Commons)

1:30-2:30

"Modeling the Depression in Resting Metabolic Rate During Energy Deficit in Humans."
Janet A. Novotny & William V. Rumpler, USDA, Human Performance Lab, BHNRC, Beltsville, MD.

Compartmental modeling of aging, survival and mortality data

2:30-3:30

"Longevity and Mortality Dynamics of Medflies Under Protein Deprivation."
Jane-Ling Wang, Statistics Division, University of California, Davis, CA.

3:30-3:45

Break

4:00-6:00

Modeling Workshops / Practice / Posters

Stephen P. Coburn, Biochemistry Department, Fort Wayne State Development Center, Fort Wayne, IN.
Michael H. Green, Nutrition Department, Pennsylvania State University, University Park, PA.
Heidi Johnson, Animal Science Department, University of California, Davis, CA

6:00-7:30

Dinner (Tercero Dining Commons)

ALL DAY

Modeling Workshops / Practice / Posters

Wednesday (August 20) (Abstracts)
Analytical Assays and Isotopic Tracer Analysis in Biological Tissues (Chair: A. Daniel Jones)
8:00-9:00	*"Statistical Perspectives on Assay Development.*" David M. Giltinan. Department of Biostatistics, Genentech Inc., South San Francisco, CA.
9:00-10:00	*"Preparation and Analysis of Biological Materials for Stable Isotopes by Plasma Source* *Mass Spectrometry."* Ramon M. Barnes, Yves Gelinas, and Antoneta Krushevska, Department of Chemistry, Lederle Graduate Research Center, University of Massachusetts, Amherst, MA.
10:00-10:15	Break
10:15-11:15	"Protocol Development for Tracer Studies: Considerations and Perspectives." Stephen R. Dueker¹, A. Daniel Jones², Andrew J. Clifford¹. Nutrition Department¹ and Facility for Advanced Instrumentation², University of California, Davis, CA.
11:15-12:15	*"Accelerator Mass Spectrometry as a Bioanalytical Tool."* John S. Vogel. Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA.
12:30-1:30	Lunch (*Tercero Dining Commons*)
1:30-3:30	*Review of Conference Highlights and Future Plans*

8:00 - Noon	Modeling Workshops / Practice / Posters
	Ray C. Boston, Clinical Studies Dept, NBC, University of Penn. School of Vet Med, Kenneth Square, PA. Stephen P. Coburn, Biochemistry Department, Fort Wayne State Development Center, Fort Wayne, IN. David M. Foster, Center for Bioengineering, University of Washington, Seattle, WA. Michael H. Green, Nutrition Department, Pennsylvania State University, University Park, PA.

Menu
Barbeque Dinner & Mixer
Sunday, August 17

Lime Cilantro Chicken Breasts
Cheese Tortellini Primavera
Aggie Beans
Corn Cobbettes
Tomato, Cucumber, Onion Salad
California Fruit Salad
Watermelon
Chocolate Cake
Lemonade, Iced Tea
Complimentary Serving of California Wine
No Host Bar

Conference Registration

Mail/Fax the below Registration information to:
Mathematical Models in Experimental Nutrition VI
Attn: Andrew J. Clifford
Nutrition Department
University of California
One Shields Avenue
Davis, CA 95616-5270
FAX: 530-752-8966

Make checks payable to Regents, University of California
You will receive further information regarding accommodation and meals.

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Registration is limited to the first 100 respondents.

__ I will be bringing a poster to display.

__ I will be submitting an abstract.

__ I would like information on local accommodations.
(Participants must make their own travel/lodging arrangements.)

__ I have enclosed a check/purchase order for $300, payable to
Regents, University of California (Registration covers Sundays
Mixer/Dinner) Mail to: A. J. Clifford, Nutrition Department,
UCD, Davis, CA 95616

__ Please charge the following Master Card/VISA Card:

Account # _______________ Exp ___________

Signature ___________________________________________

Graduate Student Rate: $100. Advisor Signature required:_______________________

CONTACT INFORMATION

For further information, please contact:

Andrew J. Clifford
ajclifford@ucdavis.edu
Department of Nutrition
University of California
One Shields Avenue
Davis, CA 95616-5270
Phone: (530) 752-3376
Fax: (530) 752-8966

or

Hans-Georg Mueller
hgmueller@ucdavis.edu
Division of Statistics
University of California
One Shields Avenue
Davis, CA 95616-8705
Phone: (530) 752-1629
Fax: (530) 752-7099