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Janet Y. Uriu-Adams

Janet Y. Uriu-Adams

  • Associate Researcher, Department of Nutrition

3205 Meyer

(530) 752-4658

jyuriuadams@ucdavis.edu

Email

Education

  • B.S., University of California, Berkeley
  • Ph.D., University of California, Davis

Research Interests

Dr. Uriu-Adams´ research focuses on investigating the mechanisms underlying copper and zinc deficiency-induced abnormal pre- and early postnatal development in mammals. Of particular interest is how the above affects oxidative and nitrosative stress, nitric oxide metabolism, and protein nitration. The effects of genetically-induced altered copper metabolism on development are assessed using mice lacking one allele of the copper transporter, Ctr-1. In addition, Dr. Uriu-Adams is investigating the influence of select diseases such as diabetes, Menkes disease, and asthma on mineral metabolism in humans and animal models.

Selected Publications

  • Uriu-Hare JY, Stern JS, Reaven GM, and Keen CL. The effect of maternal diabetes on trace element status and fetal development in the rat. Diabetes 1985;34:1031-40.
  • Keen CL, Lonnerdal B, Golub MS, Uriu-Hare JY, Olin KL, Hendrickx AG, and Gershwin ME. Influence of marginal maternal zinc deficiency on pregnancy outcome and infant zinc status in rhesus monkeys. Pediatr Res 1989;26:470-7.
  • Uriu-Hare JY, Stern JS, and Keen CL. Influence of maternal dietary Zn intake on expression of diabetes-induced teratogenicity in rats. Diabetes 1989;38:1282-90.
  • Romero-Chapman N, Lee J, Tinker D, Uriu-Hare JY, Keen CL, and Rucker RR. Purification, properties and influence of dietary copper on accumulation and functional activity of lysyl oxidase in rat skin. Biochem J 1991;275 ( Pt 3):657-62.
  • Walter RM, Jr., Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW, and Keen CL. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 1991;14:1050-6.
  • Keen CL, Uriu-Hare JY, Swan SH, and Neutra RR. The effects of water source on reproductive outcome in Fischer-344 rats. Epidemiology 1992;3:130-3.
  • Uriu-Hare JY, Walter RM, Jr., and Keen CL. 65zinc metabolism is altered during diabetic pregnancy in rats. J Nutr 1992;122:1988-98.
  • Gacheru S, McGee C, Uriu-Hare JY, Kosonen T, Packman S, Tinker D, Krawetz SA, Reiser K, Keen CL, and Rucker RB. Expression and accumulation of lysyl oxidase, elastin, and type I procollagen in human Menkes and mottled mouse fibroblasts. Arch Biochem Biophys 1993;301:325-9.
  • Jankowski MA, Uriu-Hare JY, Rucker RB, and Keen CL. Effect of maternal diabetes and dietary copper on fetal development in rats. Reprod Toxicol 1993;7:589-98.
  • Keen CL, Lonnerdal B, Golub MS, Olin KL, Graham TW, Uriu-Hare JY, Hendrickx AG, and Gershwin ME. Effect of the severity of maternal zinc deficiency on pregnancy outcome and infant zinc status in rhesus monkeys. Pediatr Res 1993;33:233-41.
  • Oster MH, Uriu-Hare JY, Trapp CL, Stern JS, and Keen CL. Dietary macronutrient composition influences tissue trace element accumulation in diabetic Sprague-Dawley rats. Proc Soc Exp Biol Med 1994;207:67-75.
  • Jankowski MA, Uriu-Hare JY, Rucker RB, Rogers JM, and Keen CL. Maternal zinc deficiency, but not copper deficiency or diabetes, results in increased embryonic cell death in the rat: implications for mechanisms underlying abnormal development. Teratology 1995;51:85-93.
  • Uriu-Hare JY, Swan SH, Bui LM, Neutra RR, and Keen CL. Drinking water source and reproductive outcomes in Sprague-Dawley rats. Reprod Toxicol 1995;9:549-61.
  • Miller GD, Keen CL, Stern JS, and Uriu-Hare JY. Copper absorption, endogenous excretion, and distribution in Sprague-Dawley and lean (Fa/Fa) Zucker rats. Biol Trace Elem Res 1996;53:261-79.
  • Rucker RB, Romero-Chapman N, Wong T, Lee J, Steinberg FM, McGee C, Clegg MS, Reiser K, Kosonen T, Uriu-Hare JY, Murphy J, and Keen CL. Modulation of lysyl oxidase by dietary copper in rats. J Nutr 1996;126:51-60.
  • Kosonen T, Uriu-Hare JY, Clegg MS, Keen CL, and Rucker RB. Incorporation of copper into lysyl oxidase. Biochem J 1997;327 ( Pt 1):283-9.
  • Bui LM, Taubeneck MW, Commisso JF, Uriu-Hare JY, Faber WD, and Keen CL. Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. Toxicology 1998;126:9-21.
  • Hawk SN, Uriu-Hare JY, Daston GP, Jankowski MA, Kwik-Uribe C, Rucker RB, and Keen CL. Rat embryos cultured under copper-deficient conditions develop abnormally and are characterized by an impaired oxidant defense system. Teratology 1998;57:310-20.
  • Rucker RB, Kosonen T, Clegg MS, Mitchell AE, Rucker BR, Uriu-Hare JY, and Keen CL. Copper, lysyl oxidase, and extracellular matrix protein cross-linking. Am J Clin Nutr 1998;67:996S-1002S.
  • Tchaparian EH, Uriu-Adams JY, Keen CL, Mitchell AE, and Rucker RB. Lysyl oxidase and P-ATPase-7A expression during embryonic development in the rat. Arch Biochem Biophys 2000;379:71-7.
  • Uriu-Adams JY, Kevin Reece C, Nguyen LK, Horvath BJ, Nair R, Barter RA, and Keen CL. Effect of butyl benzyl phthalate on reproduction and zinc metabolism. Toxicology 2001;159:55-68.
  • Hawk SN, Lanoue L, Keen CL, Kwik-Uribe CL, Rucker RB, and Uriu-Adams JY. Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions. Biol Reprod 2003;68:896-903.
  • Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, and Uriu-Adams JY. The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr 2003;133:1597S-605S.
  • Keen CL, Hanna LA, Lanoue L, Uriu-Adams JY, Rucker RB, and Clegg MS. Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects. J Nutr 2003;133:1477S-80S.
  • Cui CT, Uriu-Adams JY, Tchaparian EH, Keen CL, and Rucker RB. Metavanadate causes cellular accumulation of copper and decreased lysyl oxidase activity. Toxicol Appl Pharmacol 2004;199:35-43.
  • Daston GP, and Uriu-Adams JY. How does nutrition influence development? . In: Teratology Primer. Fugh-Berman A, Hales BF, Scialli AR, Tassinari MS, eds. Teratology Society: Wiley-Liss Publishing, 2005:69-71.
  • Kazaks A, Uriu-Adams JY, Stern JS, and Albertson TE. No significant relationship between exhaled nitric oxide and body mass index in people with asthma. J Allergy Clin Immunol 2005;116:929-30; author reply 30.
  • Uriu-Adams JY, and Keen CL. Copper, oxidative stress, and human health. Mol Aspects Med 2005;26:268-98.
  • Uriu-Adams JY, Rucker RB, Commisso JF, and Keen CL. Diabetes and dietary copper alter 67Cu metabolism and oxidant defense in the rat. J Nutr Biochem 2005;16:312-20.
  • Beckers-Trapp ME, Lanoue L, Keen CL, Rucker RB, and Uriu-Adams JY. Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos. Free Radic Biol Med 2006;40:35-44.
  • Kazaks AG, Uriu-Adams JY, Albertson TE, and Stern JS. Multiple measures of magnesium status are comparable in mild asthma and control subjects. J Asthma 2006;43:783-8.
  • Yang SJ, Uriu-Adams JY, Keen CL, Rucker RB, and Lanoue L. Effects of copper deficiency on mouse yolk sac vasculature and expression of angiogenic mediators. Birth Defects Res B Dev Reprod Toxicol 2006;77:445-54.
  • Yang SJ, Keen CL, Lanoue L, Rucker RB, and Uriu-Adams JY. Low nitric oxide: a key factor underlying copper deficiency teratogenicity. Free Radic Biol Med 2007;43:1639-48.
  • Kazaks AG, Uriu-Adams JY, Albertson TE, Shenoy SF and Stern JS. Effect of magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate ashtma: a randomized placebo controlled trial.  Journal of Asthma 2010;47:83-92.
  • Keen CL, Uriu-Adams JY, Skalny A, Grabeklis A, Grabeklis S, Green K, Yevtushok L, Wertelecki WW and Chambers CD.  The plausibility of maternal nutritional status being a contributing factor to the risk for Fetal Alcohol Spectrum Disorders:  The potential influence of zinc status as an example.  BioFactors 2010;36:125-35.
  • Uriu-Adams JY, Scherr ER, Lanoue L and Keen CL.  Influence of copper on early development: prenatal and postnatal considerations. BioFactors 2010;36:136-152.
  • Uriu-Adams JY and Keen CL.  Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development.  Birth Defects Research Part B: Developmental and Reproductive Toxicology. 2010;89:313-325.