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Carolyn M. Slupsky

Carolyn M. Slupsky

  • Assistant Professor, Department of Nutrition/ Department of Food Science & Technology
  • Assistant Nutritionist in Agricultural Experiment Station

3247 Meyer

(530) 219-5757

cslupsky@ucdavis.edu

Email

Education

  • Ph.D., Biochemistry, University of Alberta
  • B.Sc., Biochemistry, University of Alberta

Research Interests

Dr. Slupsky’s research interests include the application of analytical metabolomics for the purpose of studying cellular metabolism as it relates to food, nutrient intake, and health status. She predominantly uses NMR spectroscopy to collect as much chemical information as possible about the identity and concentrations of metabolites in cell cultures, tissues, and body fluids obtained from animal models and humans.

Selected Publications

  • McNiven EM, German JB, Slupsky CM. Analytical metabolomics: nutritional opportunities for personalized health.J Nutr Biochem. 2011 Nov;22(11):995-1002.
  • Zhang X, Breksa AP 3rd, Mishchuk DO, Slupsky CM. Elevation, rootstock, and soil depth affect the nutritional quality of mandarin oranges. J Agric Food Chem. 2011 Mar 23;59(6):2672-9. Epub 2011 Feb 20.
  • Moroz J, Turner J, Slupsky C, Fallone G, Syme A. Tumour xenograft detection through quantitative analysis of the metabolic profile of urine in mice. Phys Med Biol. 2011 Feb 7;56(3):535-56. Epub 2011 Jan 6.
  • Slupsky CM, Steed H, Wells TH, Dabbs K, Schepansky A, Capstick V, Faught W, Sawyer MB. Urine metabolite analysis offers potential early diagnosis of ovarian and breast cancers. Clin Cancer Res. 2010 Dec 1;16(23):5835-41. Epub 2010 Oct 18.
  • Wang H, Tso VK, Slupsky CM, Fedorak RN. Metabolomics and detection of colorectal cancer in humans: a systematic review. Future Oncol. 2010 Sep;6(9):1395-406. Review.
  • Sekar Y, Moon TC, Slupsky CM, Befus AD. Protein tyrosine nitration of aldolase in mast cells: a plausible pathway in nitric oxide-mediated regulation of mast cell function. J Immunol. 2010 Jul 1;185(1):578-87. Epub 2010 May 28.
  • Slupsky CM (2010) "NMR-based analysis of metabolites in urine provides a rapid diagnosis and etiology of pneumonia." Biomark Med 4: 195 -197.
  • Slupsky CM, Rankin KN, Fu H, Chang D, Rowe BH, Charles PGP, McGeer A, Low D, Long R, Kunimoto D, Sawyer MB, Fedorak RN, Adamko DJ, Saude EJ, Shah SL, Marrie TJ  (2009) "Determination of the etiology of pneumonia through urinary metabolomics." J Proteome Res 8, 5550 - 5558.
  • Slupsky CM, Cheypesh A, Chao D, Fu H, Rankin KN, Marrie TJ, Lacy P (2009) "Differences in the metabolic response to pneumonia caused by Streptococcus pneumoniae or Staphylococcus aureus." J Proteome Res 8, 3029 - 3036.
  • Takeda I, Stretch C, Barnaby P, Bhatnager K, Rankin K, Fu H, Weljie A, Jha N, Slupsky CM (2009) "Understanding the human salivary metabolome." NMR Biomed 22: 577 - 584.
  • Mahadevan S, Shah SL, Marrie TJ, Slupsky CM (2008) "Analysis of Metabolomic Data using Support Vector Machines." Anal Chem 80, 7562-7570.
  • Murdoch TB, Fu H, Martin S, Sydora B, Fedorak RN, Slupsky CM (2008) "Urinary metabolic profiles reveal progression of inflammatory bowel disease in interleukin-10 gene deficient mice." Anal Chem 80, 5524-5531.
  • McGrath BM, McKay R, Dave S, Seres P, Weljie AM, Slupsky CM, Hanstock CC, Greenshaw AJ, Silverstone PH (2008) "Acute dextro-amphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3T and 18.8T." Neurosci Res 61, 351 - 359.
  • Slupsky CM, Rankin KN, Wagner J, Fu H, Chang D, Weljie AM, Saude EJ, Lix B, Adamko DJ, Shah S, Greiner R, Sykes BD, and Marrie TJ (2007) "Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles." Anal Chem 79, 6995 - 7004.
  • Slupsky CM, Spyracopoulos L, Booth VK, Crump MP, and Sykes BD (2007) "Probing nascent structures in peptides using natural abundance 13C NMR relaxation and reduced spectral density mapping." Proteins 67, 18 - 30.
  • McGrath BM, Greenshaw AJ, McKay R, Slupsky CM, and Silverstone PH (2007) "Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol." Neuroreport 18, 1595 - 1598.
  • McGrath BM, Greenshaw AJ, McKay R, Slupsky CM, and Silverstone PH (2006) "Lithium treatment alters regional rat brain myo-inositol concentrations at 2 and 4 weeks: An Ex Vivo MRS study at 18.8 Tesla." NeuroReport 17, 1323 - 1326.
  • Saude EJ, Slupsky CM, and Sykes BD (2006) "Optimization of NMR analysis of biological fluids for quantitative accuracy." Metabolomics 2, 113 - 123.
  • Weljie AM, Newton J, Mercier P, Carlson E and Slupsky CM (2006) "Targeted profiling: Quantitative analysis of 1H-NMR metabolomics data." Anal Chem 78, 4430 - 4442.
  • Graether SP, Slupsky CM, and Sykes BD (2006) "Effect of a mutation on the structure and dynamics of an a-helical antifreeze protein in water and ice." Proteins 63, 603 - 610.