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Javier Ottaviani

Javier Ottaviani

  • Associate in AES
  • Manager of MARS CoreLab at UC Davis, MARS, Incorporated

3150D Meyer

(530) 752-3548

jottaviani@ucdavis.edu

Email

Education

  • Ph.D., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
  • B.Sc./M.S., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

Research Interests

Dr. Ottaviani’s research focuses on understanding the beneficial effects of dietary flavanols and procyanidins on cardiovascular health. His interests include i) the characterization of absorption, distribution, metabolism and excretion of flavanols and procyanidins in humans and other species; ii) the development and validation of methodologies capable of quantifying flavanols and procyandins in different biological samples, and iii) elucidating the biochemical mechanisms behind the vascular effects mediated by flavanol and procyanidin consumption.

Selected Publications

  • Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. Ottaviani JI, Kwik-Uribe C, Keen CL, Schroeter H. Am J Clin Nutr. 2012 Feb 29.
  • Structurally related (-)-epicatechin metabolites in humans: Assessment using de novo chemically synthesized authentic standards. Ottaviani JI, Momma TY, Kuhnle GK, Keen CL, Schroeter H. Free Radic Biol Med. 2011 Dec 23.
  • The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL. Free Radic Biol Med. 2011 Jan 15;50(2):237-44. Epub 2010 Nov 11.
  • Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. J Am Coll Cardiol. 2010 Jul 13;56(3):218-24.