UC Davis Nutrition Department Faculty

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Patricia Oteiza
Associate Professor
Department of Nutrition
Nutritionist in Agricultural Experiment Station 

Office: 3109 Meyer
Phone: (530) 754-6074
Email: poteiza@ucdavis.edu


Education
Ph.D., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
M.S., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
M.S., Clinical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

Research Interests
Dr. Oteiza has two primary areas of research. The first is centered on the characterization of the effects of trace mineral deficiencies, and trace mineral toxicities, on early developmental processes. Dr. Oteiza’s second area of research is focused on the putative health benefits of flavonoids.


Selected Publications
Pasquini, J.M., Bizzozero, O., Sato, C., Oteiza, P. I., and Soto, E.F. Abnormal myelinogenesis and changes in brain cell membranes in neonatal malnutrition in the rat. En New Trends in Nutrition, Lipid Research and Cardiovascular Diseases (Bazan, N., Paoletti, R. and Iacono, J., Eds.) Alan Liss, New York, pp. 73-89, 1981.

Pasquini, J.M., Bizzozero, O., Sato, C., Oteiza, P. I., and Soto, E.F. Neonatal hypotyrodism and early undernutrition affect myelin and myelin precursor membranes in a different way. International Journal of Develpmental Neurosciences 1:105-111 (1983)

Pasquini, J.M., De Paoli, T., Hager, A.A., Oteiza, P.I. and Soto, E.F. Biochemical and biophysical studies on the action of thyroid hormones upon cell membranes. En New Concepts in Thyroid Diseases . (Soto R., Sartorio, G. and De Forteza, I., Eds) Alan Liss, New York, pp. 45-46, 1983.

Pasquini, J.M., Oteiza, P.I., De Paoli, T., Hager, A.A., Faryna, I.A. and Soto, E.F. The effect of thyroid hormones upon phospholipid composition and CDP-choline incorporation in mitochondria. En Novel Biochemical, Pharmacological and Clinical Aspects of Cytidinediphosphocholine (Zappia, V., Kennedy, E.P., Nilsson, B.I. and Galetti, P., Eds) Elsevier Science Publishing Co., New York, pp. 25-34, 1985.

Oteiza, P.I. Adamo, A.M., Aloise, P.A., Paladini, A.C., Paladini, A.A. and Soto E.F. Cysteinyl residues of bovine white matter proteolipid proteins. Role of disulphides in proteolipids conformation. Biochemical Journal 245:507-513 (1987)

Oteiza, P.I., Hurley, L.S., Lonnerdal, B. and Keen, C.L. Marginal zinc deficiency affects maternal brain microtubule assembly in rats. Journal of Nutrition 118:735-738 (1988)

Oteiza, P.I. Revisión del libro: Basic and clinical aspects of nutrition and brain development. Journal of Nutrition 118:1598 (1988)

Oteiza, P.I., Keen, C.L., Lonnerdal, B. and Hurley, L.S. Marginal zinc deficiency affects pup brain microtubule assembly in rats. En Trace Elements in Man and Animals (Hurley, L.S., Keen, C.L., Lonnerdal, B. and Rucker, R.B., Eds.) Plenum Press, New York, pp. 631-632, 1989

Pasquini J.M., Guarna M.M., Besio Moreno M.A., Iturregui, M.T., Oteiza, P.I. and Soto, E.F. Inhibition of the synthesis of glycosphingolipids affects the traslocation of proteolipid protein to the myelin membrane. Journal of Neuroscience Research 22:289-296 (1989)

Oteiza, P.I., Golub, M.S., Gershwin, M.E., Donald, J.M. and Keen, C.L. The influence of high dietary aluminum on brain microtubule polymerization in mice. ToxIcology Letters 47:279-285 (1989)

Oteiza, P.I., Cuellar S., Lonnerdal, B., Hurley, L.S. and Keen, C.L. Influence of maternal dietary zinc intake on in vitro tubulin polymerization in fetal brain. Teratology 41:97-104 (1990)

Oteiza, P.I., Hurley, L.S., Lonnerdal, B. and Keen, C.L. Effects of marginal zinc deficiency on microtubule polymerization in the developing rat brain. Biological Trace Elements Research 24:13-23 (1990)

Fraga, C.G., Oteiza, P.I., Golub, M.S., Gershwin, M.E. and Keen, C.L. Effects of aluminum on brain lipid peroxidation. Toxicology Letters. 51: 213-219 (1990)

Rogers, J.M., Oteiza, P.I. and Keen, C.L. Zinc and manganese deficiencies in prenatal and neonatal development with special reference to the central nervous system. En: (Mal)Nutrition and infant brain (Gelder, N.M., Butterworth, R.F. and Drujan, B.D., eds) Wiley-Liss, New York, pp. 225-236, 1990

Oteiza, P.I. and Keen, C.L. Glycerophospholipid synthesis in zinc deficient rats. In: Trace Elements in Man and Animals (Momcilovic, B., Ed.), IMI, Zagreb, Yugoslavia. pp. 7:18-8, 1991.

Oteiza, P. I. Trastornos ocasionados por deficiencia de zinc. (1991) Ciencia Hoy 3:18-19

Liu, H., Oteiza, P.I., Gershwin, M.E., Golub, M.S.and Keen, C.L. Effects of maternal marginal zinc deficiency on myelin protein profiles in the suckling rat and infant rhesus monkey. Biological Trace Element Research. 34:55-66 (1992)

Oteiza, P.I., Fraga C.G. and Keen, C.L. Aluminum has both oxidant and antioxidants effects in mouse brain membranes in vitro. Archives of Biochemistry and Biophysics 300:517-521 (1993)

Oteiza, P.I., Keen, C.L., B. Han and Golub, M. S. Aluminum accumulation and neurotoxicity in Swiss-Webster mice after chronic dietary exposure to aluminum and citrate. Metabolism 42:1296-1300 (1993)

Oteiza, P.I. and Bechara, E.J.H. 5-Aminolevulinic Acid Induces Lipid Peroxidation in Cardiolipin-rich Liposomes. Archives of Biochemistry and Biophysics 305:282-287 (1993).

Oteiza, P.I. A mechanism for the stimulatory effect of aluminum on iron-induced lipid peroxidation. Archives of Biochemistry and Biophysics 308:374-379 (1994)

Oteiza, P. I., Kleinman, C. G, Demasi, M. and Bechara, E.J.H. 5-Aminolevulinic acid induces iron release from ferritin. Archives of Biochemistry and Biophysics 316:607-611 (1995)

Fraga, C. G. y Oteiza, P.I. Vitaminas antioxidantes: bioquímica, nutrición y participación en la prevención de ciertas patologías. Boletín de Educación Bioquímica 14: 12-17 (1995)

Oteiza, P. I., Olin, K, Fraga, C. G.. and Keen, C. L. Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. Journal of Nutrition 125:823-829 (1995)

Oteiza, P. I. Modificación oxidativa de proteínas. Antioxidantes y calidad de vida 2:12-20 (1995)

Verstraeten, S. V. and Oteiza, P. I. Sc3+, Ga3+, In3+, Y3+, and Be2+ promote changes in membrane physical properties and facilitate Fe2+-initiated lipid peroxidation. Archives of Biochemistry and Biophysics 322:284-290 (1995)

Oteiza, P. I. Radicales libres y nutrición. Antioxidantes y calidad de vida 2:11-12 (1995)

Oteiza, P. I., Verstraeten, S. V. and Adonaylo, V. N. Oxidative damage induced by metals without redox capacity in biological systems. Ciencia e Cultura 47:330-335 (1995)

Oteiza, P. I., Olin, K, Fraga, C. G. and Keen, C. L. Oxidant defense systems in testes from zinc deficient rats. Proceedings of the Society of Experimental Biology and Medicine 213:85-91 (1996)

Fraga, C. G., Lotito, S. B., Carrasquedo, F., Cavanagh, E. M. V. de and Oteiza, P.I. Antioxidant defenses and mechanisms of protection against oxygen radicals. En Physiology and Biochemistry of the Fishes of the Amazon. (Val, A. L., Almeida-Val, V. M. F. and Randall, D. J., eds) pp. 323-330, 1996

Verstraeten, S. V., Scherier, S., Nogueira, L. and Oteiza, P. I. Effect of trivalent metal ions on phase separation and membrane lipid packing. Role in lipid peroxidation. Archives of Biochemistry and Biophysics 338:121-127 (1997)

Oteiza,P. I., Uchitel, O. D., Carrasquedo, F., Dubrovski, A. L., Roma, J. C. and Fraga, C. G. Evaluation of antioxidants, lipid and protein oxidation parameters in patients with amiotrophic lateral sclerosis. Journal of Neurochemical Research 22:535-539 (1997)

Verstraeten, S. V., Golub, M. S., Keen, C.L., and Oteiza, P. I. Myelin is a preferential target for aluminum-mediated oxidative damage. Archives of Biochemistry and Biophysics 344:289-294 (1997)

Oteiza, P. I. Radicales libres en la enfermedad de Alzheimer. (1997)Ciencia Hoy 7:41

Verstraeten, S. V., Keen, C.L., Golub, M. S., and Oteiza, P. I. Membrane composition can influence the rate of Al3+-mediated lipid oxidation. Effect of galactolipids. Biochemical Journal 333:833-838 (1998)

Adamo, A. M., Pasquini, L., Besio Moreno, M., Oteiza, P. I., Soto, E. F. and Pasquini, J. M. Ubiquitylation of oxidized proteins in the central nervous system. Journal of Neurochemical Research 55:523-531 (1999)

Adonaylo, V. N. and Oteiza, P. I. Pb2+ promotes lipid oxidation and alterations in membrane physical properties. Toxicology 132:19-32 (1999)

Adonaylo, V. N. and Oteiza, P. I. Lead intoxication: antioxidant defenses and oxidative damage in rat brain. Toxicology 135:577-85 (1999)

Meglio, L. and Oteiza, P. I. Aluminum enhances melanin-induced lipid peroxidation Neurochemical Research 24:1003-1010 (1999)

Oteiza, P. I., Adonaylo, V. and Keen, C. L. Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. Toxicology 137:13-22 (1999)

Verstraeten, S. V. and Oteiza, P. I. Effects of aluminum and related metals on membrane phase state and hydration. Correlation with lipid oxidation. Archives of Biochemistry and Biophysics 375:340-346 (2000)

Oteiza, P. I., Clegg, M. S., Zago, M. P. and Keen, C. L. Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radicals in Biology and Medicine 28: 1091-1099 (2000)

Zago, M. P., Verstraeten, S. V. and Oteiza, P. I. Zinc in the prevention of Fe2+-initiated lipid and protein oxidation. Biological Research 33: 143-150 (2000)

Oteiza, P. I., Clegg, M. S. and Keen, C. L. Short-term zinc deficiency affects NF-kB nuclear binding activity in rat testes. Journal of Nutrition 131: 21-26 (2001)

Zago, M. P and Oteiza, P. I. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radicals in Biology and Medicine 31: 266-274 (2001)

Oteiza, P. I., Verstraeten, S. V. y Zago, M. P. Modulación de la oxidación lipídica por metales sin capacidad redox. Antioxidantes y calidad de vida 8, 14-18 (2001)

Verstraeten, S. V., Erlejman, A. G., Zago, M. P., and Oteiza, P. I. Aluminum selectively affects membrane physical properties in human neuroblastoma (IMR-32) cells before and after differentiation. Archives of Biochemistry and Biophysics 399: 167-173 (2002)

Actis-Goreta, L., Mackenzie, G. G., Oteiza, P. I. and Fraga, C. G. Comparative study of the antioxidant capacity of wines and other plant-derived beverages. Annals of the New York Academy of Sciences 957: 1-5 (2002)

Fraga, C. G. and Oteiza, P. I. Iron toxicity and antioxidant nutrients. Toxicology 180: 23-32 (2002)

Mackenzie, G. G., Zago, M. P., Keen, C. L. and Oteiza, P. I. Low intracellular zinc impairs the translocation of activated NF-kB to the nuclei in human neuroblastoma IMR-32 cells. Journal of Biological Chemistry 277:34610-34617 (2002)

Erlejman, A. G. and Oteiza P.I. The oxidant defense system in human neuroblastoma IMR-32 cells pre- and post- differentiation to neuronal phenotypes. Neurochemical Research 27: 1491-1498 (2002)

Mackenzie, G. G., Keen, C. L. and Oteiza, P. I. The zinc status of human neuroblastoma IMR-32 cells influences their susceptibility to iron-induced oxidative stress. Developmental Neuroscience 24: 125-133 (2002)

Verstraeten, S. V., Keen, C. L., Schmitz, H. H., Fraga, C. G. and Oteiza, P. I. Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radicals in Biology and Medicine 34: 84-92 (2003)

Verstraeten, S. V., and Oteiza, P. I. Aluminum-mediated changes on membrane physical properties participate in the inhibition of polyphosphoinositides hydrolysis. Archives of Biochemistry and Biophysics 408:263-271 (2002)

Actis-Goreta, L., Mackenzie, G. G., Oteiza, P. I. and Fraga, C. G. Polyphenols containing beverages protect cultured cells, human plasma, liposomes, and a pure chemical system, from free radical-mediated oxidation. Alternate Medicine and Emerging Drugs (in press)

Verstraeten, S. V., Villaverde, M. S. and Oteiza, P. I. Aluminum-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC. Chemistry and Physics of Lipids 122:159-163 (2003)

Verstraeten, S. V., and Oteiza, P. I. Aluminum-mediated changes on membrane physical properties participate in the inhibition of polyphosphoinositides hydrolysis. Archives of Biochemistry and Biophysics 408:263-271 (2003)

Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 1;378(Pt 2):579-87.

Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan;18(1):167-9. Epub 2003 Nov 20.

Oteiza PI, Mackenzie GG, Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr;25(1-2):103-15. Review.

Verstraeten SV, Oteiza PI, Fraga CG. Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells. Biol Res. 2004;37(2):293-300.


 


Department of Nutrition | 3135 Meyer Hall | University of California | One Shields Avenue
Davis, CA 95616-5270
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