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John W. Newman

John W. Newman

  • Associate Adjunct Professor, Department of Nutrition
  • USDA ARS Western Human Nutrition Research Center Scientist

210 WHNRC

(530) 752-1009

john.newman@ars.usda.gov

Email

Education

  • B.A, Biochemistry & Molecular Biology, University of California, Santa Cruz
  • Ph.D., Pharmacology & Toxicology, University of California, Davis

Research Interests

Dr. Newman’s laboratory uses analytical technologies to investigate the interactions of diet and metabolism on nutritional phenotypes in the context of obesity and associated co-morbidities, developing novel analytical tools as needed to address these questions.

Selected Publications

  • Watkins, S.M., B.D. Hammock, J.W. Newman, J.B. German. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am J Clin Nutr. 74(3):283-6.
  • Newman, J.W., T. Watanabe, B.D. Hammock. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by high-performance liquid chromatography - tandem mass spectroscopy. J Lipid Res. 43:1563-1578.
  • Newman, J.W., C. Morisseau, T.R. Harris, B.D. Hammock. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Nat Acad Sci USA. 100(4):1558-63.
  • Dey, A., R.S. Williams, D.M. Pollock, D.W. Stepp, J.W. Newman, B.D. Hammock, J.D. Imig. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12:1278-89.
  • Newman, J.W., C. Morisseau, B.D. Hammock. 2005. Epoxide hydrolases: Their role and interactions with lipid metabolism. Prog Lipid Res. 44:1-51.
  • Schmelzer, K., L. Kubala, J. Eiserich, J.W. Newman, B.D. Hammock. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. PNAS. 102(28):9772-77.
  • Luria, A., S.M. Weldon, A.K. Kabcenell, R.H. Ingraham, D. Matera, R. Gill, C. Morisseau, J.W. Newman , B.D. Hammock. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice. J Biol Chem. 282(5):2891-2898.
  • Wheelock, C.E., S. Goto, B.D. Hammock, J.W. Newman. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics. 3(2):137-145.
  • Newman, J.W., B.D. Hammock, G.A. Kaysen, G.C. Shearer. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J. Lipid Res. 48(8):1792-800.
  • Driesbach, A., J.C. Rice,S. Japa,J.W. Newman,A. Sigel, R.S. Gill, A.E. Hess, B.D. Hammock, J.J.L. Lertora, L.L. Hamm. 2008. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects.  Hypertension. 51:755-761.
  • Sanchez-Mejia, R.S., J.W. Newman, S. Toh, G-Q. Yu, Y. Zhou, K. Scearce-Levie, I.H. Cheng, L. Gan, J.J. Palop, J.V. Bonventre, L. Mucke.  2008. Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer’s disease. Nat Neurosci. 11(11):1311-8.
  • Wang, L., R. Gill, T.L. Pedersen, J.W. Newman, J.C. Rutledge. 2009. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that induce endothelial cell inflammation.  J. Lipid Res. 50(2):204-13 [EPub Sept, 2008].
  • Shearer, G.C, J.W. Newman. 2008. Lipoprotein lipase liberates esterified oxylipins from very low-density lipoproteins. Prostaglandins Leukot. Essent. Fatty Acids. 79(6):215–22.
  • Paulino, G., C.B. de la Serre, T. Knotts, P. Oort, J.W. Newman, S. Adams, H. Raybould. 2009. Altered expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. Am. J. Physiol. – Endocrin. Metab. [E-Pub Feb. 3, 2009].
  • Adams, S.H., C.L. Hoppel, K. Lok, L. Zhao, S. Wong, P.E. Minkler, D.H. Hwang, J.W Newman, W.T. Garvey. 2009. Plasma acylcarnitine profiles suggest incomplete fatty acid β-oxidation and altered TCA cycle activity in type 2 diabetes. J. Nutr. 139(6):1073-81.
  • Shearer, G.C., W.S. Harris, T.L. Pedersen, J.W. Newman. 2009. Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters.  J. Lipid Res. [EPub Aug, 2009].
  • Shearer, G.C., J.W. Newman. 2009. Impact of circulating esterified eicosanoids and other oxylipins on endothelial function. Curr. Atheroscler. Rep. 11(6):403-10.
  • van Erk, M.J., S. Wopereis, C. Rubingh, T. van Vliet, E. Verheij, N.H.P. Cnubben, T. L. Pedersen, J.W. Newman, A.K.Smilde, J. van der Greef, H.F.J. Hendriks, B. van Ommen. 2010. Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. BMC Medical Genomics. 3(5).