Skip directly to: Main page content
Siming Liu

Siming Liu

  • Assistant Project Scientist, Department of Nutrition

4306 Meyer

(530)752-5611

sigliu@ucdavis.edu

Email

Education

  • Ph.D., Cell and Molecular Biology, Miami University, Ohio, USA
  • M.D., Clinical Medicine, Tianjin Medical University, China

Research Interests

Dr. Liu's research aims to address the mechanisms of islet mass loss during development of diabetes. In a close collaboration with Dr. Fawaz Haj, his research is addressing the roles of protein-tyrosine phosphatases in the regulation of islet function and survival under conditions of obesity-induced diabetes. Dr. Liu's work also focuses on dissecting the apoptotic machinery in islets destruction during the progression of type 1 and type 2 diabetes. His research uses genetically-engineered mouse models, ex vivo islet functional assays, pancreatic beta cell lines in combination with advanced imaging and electron microscopy ultrastructural analysis.

Selected Publications

  • Siming Liu, Terumasa Okada, Anke Assmann, Jamie Soto, Chong Wee Liew, Heiko Bugger, Orian Shirihai, E. Dale Abel and Rohit N. Kulkarni. Insulin signaling regulates mitochondrial function in pancreatiC beta-cells. PLoS ONE. 2009, Nov24;4(11):e7983.
  • Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. 2007. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb;56(2):311-9.
  • Liu S, Hennessey T, Rankin S, and Pennock DG. 2005. Mutations in genes encoding inner arm dynein heavy chains in Tetrahymena thermophila lead to axonemal hypersensitivity to Ca2+. Cell Motility and Cytoskeleton. 2005 Nov; 62(3):133-40.
  • Liu S, Hard R, Rankin S, Hennessey T, Pennock DG. 2004. Disruption of genes encoding predicted inner arm dynein heavy chains causes motility phenotypes in Tetrahymena. Cell Motil Cytoskeleton. 2004 Nov;59(3):201-14.