UCDavis University of California

Education

• B.S., Physical Education, Universite de Sherbrooke, Canada
• M.Sc., Nutrition, Universite de Montreal, Canada
• Ph.D., Nutrition, McGill Unviversity, Montreal, Canada

Research Interests

Dr. Lanoue´s research is directed towards achieving a better understanding of the role of specific nutrient deficits or excesses on embryonic and fetal development. The goal of the research is to identify potential mechanisms and pathogenic processes associated with the developmental defects induced by a nutrient imbalance with emphasis on the trace elements copper, zinc, boron and arsenic. The research requires the use of pre- and postimplantation embryo culture models as well as yolk sac, limb and neural crest cells culture systems, whereby changes in gross morphology, protein and gene expression are monitored using histological, imaging, immunological and molecular methodologies.

Current research projects include studies regarding

1. The effects of boron on early mouse embryonic development with emphasis on membrane function.
2. The nature and extent of embryonic oxidative damage induced by copper deficiency in mice.
3. The expression of extra-cellular proteins in heart of copper deficient rat embryos and fetuses.
4. The alteration of neural crest cell metabolism and its effect on heart malformation during zinc deficiency. Other areas of interest include looking at the epigenetic and anti-atherogenic effects of plant flavonoids during development and in adult animals.

Selected Publications

• Lanoue, L., Miniaci, S. and K.G. Koski. Placental composition does not respond to changes in maternal dietary carbohydrate intake in rats. J. Nutr. 1992;122: 2374-238.
• Koski, K.G., Lanoue, L. and S.N. Young. Restriction of maternal dietary carbohydrate decreases fetal brain indoles and glycogen in rats. 1993; J. Nutr. 123: 42-51.
• Lanoue, L. and K.G. Koski. Glucose-restricted diets alter milk composition and mammary gland development in lactating rat dams. 1994;J. Nutr. 124: 94-102.
• Koski, K.G., Lanoue, L. and S.N. Young. Restriction of maternal dietary carbohydrate influences the developmental profile of postnatal brain indoleamine metabolism. Biol. Neonate 1995;67: 127-131.
• Dehart, D.B., Lanoue, L., Tint, G.S. and K.K. Sulik. Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome. Am. J. Med. Genet. 1997;68: 328-337.
• Lanoue, L., Dehart, D.B., Hinsdale, M.E., Maeda, N., Tint, G.S. and K.K. Sulik . Limb, genital, CNS and facial malformations result from gene/envionment-induced cholesterol deficiency: further evidence for a link to sonic hedgehog. Am. J. Med. Genet. 1997;73: 24-31.
• Lanoue, L. Taubeneck, M.W., Muniz, J., Hanna, L.A., Strong, P.L., Murray, F.J., Nielsen, F.H., Hunt, C.D. and C.L. Keen. Assessing the effects of lpw boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems. Biol. Trace Elem. Res. 1998;66: 261-298.
• Lanoue, L., Strong, P.A. and C.L. Keen. Adverse effects of a low boron environment on the preimplantation development of mouse embryos in vitro. J. Trace Elem. Exp. Med. 1999;121: 235-250.
• Lanoue, L., Liu, X.J. and K.G. Koski. Postnatal profiles of glycogenolysis and gluconeogenesis are modified in rat pups by maternal dietary glucose restriction. J. Nutr. 1999;129: 820-827.
• Hawk SN, Lanoue L, Keen CL, Kwik-Uribe CL, Rucker RB, Uriu-Adams JY. Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions. Biol Reprod. 2003;68(3):896-903.
• Keen CL, Hanna LA, Lanoue L, Uriu-Adams JY, Rucker RB, Clegg MS. Developmental consequences of trace mineral deficiencies in rodents: acute and long-term effects. J Nutr. 2003;133(5 Suppl 1):1477S-80S. Review.
• Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, Uriu-Adams JY. The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr. 2003;133(5 Suppl 2):1597S-1605S. Review.