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trace elements. In: Physiology of the Gastrointestinal Tract (L.R. Johnson,
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M., Sanchez, D.J., Llobet, J.M., and Keen, C.L. Relationship between
reduction in food intake and amelioration of hyperglycemia by oral vanadate
in STZ-induced diabetic rats. (Letter) Diabetes 1994;43:1267.
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G.J., Baines, D., Taubeneck, M.W., Lehman-McKeeman, L.D., Rogers, J.M.,
and Keen, C.L. Altered Zn status by a-hederin in the pregnant rat and
its relationship to adverse developmental outcome. Reproductive Toxicology
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L.E., Johnston, K.E., and Keen, C.L. In vitro zinc stimulation of angiotensin-converting
enzyme activities in various tissues of zinc-deficient rats. Nutrition
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copper on blood pressure and indices of the antioxidant system in male
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Modulation of behavioral performance of prepubertal monkeys by moderate
dietary zinc deprivation. American Journal of Clinical Nutrition 1994;60:238-243.
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M.C., Gershwin, M.E., Picanso, J.P., Garvey, J.S., and Keen, C.L. Serum
zinc and copper concentrations in relation to spontaneous abortion in
cows: implications for human fetal loss. Journal of Reproduction and
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B., Keen, C.L., and Gershwin, M.E. Auditory startle in Swiss Webster
mice fed excess aluminum in diet. Neurotoxicology and Teratology 1994;16:423-425.
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seizures. The Lancet 1994;343:1133-1134.
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C.L., Vinters, H.V., Harris, E., Chugani, H.T., Bateman, B., Rodgerson,
D., Vargas, J., Verity, A., and Ament, M. Copper deficiency secondary
to a copper transport defect: A new copper metabolic disturbance. Metabolism
1994;43:1462-1469.
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Morse, L.S. Low glutathione reductase and peroxidase activity in age-related
macular degeneration. British Journal of Ophthalmology 1994;78:791-794.
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retention/absorption of 51chromium (51Cr) from 51Cr chloride, 51Cr nicotinate
and 51Cr picolinate in a rat model. Trace Elements and Electrolytes
1994;11:182-186.
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R.H., Keen, C.L., Summary, J.J., and Dubick, M.A. Zinc status and interleukin-1b
induced alterations in mineral metabolism in rats. Proceedings of the
Society for Experimental Biology and Medicine 1994;206:438-444.
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S., and Lonnerdal, B. Nutritional and toxicological aspects of manganese
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1994.
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J.Y., Trapp, C.L., Stern, J.S., and Keen, C.L. Dietary macronutrient
composition influences tissue trace element accumulation in diabetic
Sprague-Dawley rats. Proceedings of the Society for Experimental Biology
and Medicine 1994;207:67-75.
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L.S., Murphy, C., Paul-Murphy, J., Line, S., Bellhorn, R.W., Hjelmeland,
L.M., and Keen, C.L. Trace element status and free radical defense in
elderly rhesus macaques (Macaca mulatta) with Macular Drusen. Proceedings
of the Society for Experimental Biology and Medicine 208:370-377.
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B., Keen, C.L., Gershwin, M.E., and Tarara, R.P. Behavioral performance
of Swiss Webester mice exposed to excess dietary aluminum during development
or during development and as adults. Toxicology and Applied Pharmacology
133:64-72.
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A., and Keen, C.L. Tumor necrosis factor-a alters maternal and embryonic
zinc metabolism and is developmentally toxic in mice. Journal of Nutrition
1995;125:908-919.
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S.N., Daels, P.F., Cullov, J.S., Keen, C.L., Thurmond, M.C., Dellinger,
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F2a, plasma zinc, copper and iron concentrations and fetal loss in cows
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C.L., Gershwin, M.E., and Hendrickx, A.G. Developmental zinc deficiency
and behavior. Journal of Nutrition 1995;125:2263S-2271S.
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C.L., and Dubick, M.A. Comparative effects of six-week nicotine treatment
on blood pressure and components of the antioxidant system in male spontaneous
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K.L., Fraga, C.G., and Keen, C.L. Zinc deficiency causes oxidative damage
to proteins lipids and DNA in rat testes. Journal of Nutrition 1995;125:823-829.
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M.W., Daston, G.P., Gershwin, M.E., Ansari, A. and Rogers, J.M. Primary
and secondary zinc deficiency as factors contributing to abnormal central
nervous system development. Developmental Brain Dysfunction 1995;8:79-89.
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J.R., Wiley, L.M., and Keen, C.L. Influence of antioxidants on cadmium
toxicity of mouse preimplantation embryos in vitro. Toxicology 1995;99:11-18.
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J., Keen, C.L., McCune, S.A., Rucker, R.B., and Medeiros, D.M. Copper
deficiency alters isomyosin types and levels of laminin, fibronectin
and cytochrome C oxidase subunits from rat hearts. Comparative Biochemistry
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L.M., Zidenberg-Cherr, S., and Keen, C.L. Periconceptional zinc deficiency
affects uterine 3H-estradiol binding in mice. Teratogenesis, Carcinogenesis,
and Mutagenesis 1995;15:23-31.
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J.R., Wiley, L.M., Rucker, R.B., and Keen, C.L. Effect of a metallothionein
antisense oligonucleotide on embryo development. Reproductive Toxicology
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M.S., Gershwin, M.E., Hendrickx, A.G., Lonnerdal, B., and Keen, C.L.
Extracellular superoxide dismutase activity is affected by dietary zinc
intake in non-human primate and rodent models. American Journal of Clinical
Nutrition 1995;61:1263-1267.
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Keen, C.L., Hong, K.H., Gershwin, M.E., and Fletcher, M.P. Alterations
in the chemotactic and respiratory burst responses of peripheral blood
neutrophils from zinc deficient rats. Journal of Nutritional Immunology
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zinc deficiency, but not copper deficiency or diabetes results in increased
embryonic cell death in the rat: Implications for mechanisms underlying
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M.A., and Keen, C.L. Zinc deficiency causes apoptosis but not cell cycle
alterations in organogenesis-stage rat embryos: Effect of varying duration
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C.L., and Donovan, S.M. Zinc deficiency influences the distribution
of serum insulin-like growth factor binding proteins in the rat. Metabolism
1995;44:1495-1501.
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Swan, S.H., Bui, L.M., Neutra, R.R., and Keen, C.L. Drinking water source
and reproductive outcomes in Sprague-Dawley rats. Reproductive Toxicology
1995;9:549-561.
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M., Sanchez, D., Llobet, J.M., and Keen, C.L. Toxicology of vanadium
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Behavioral changes associated with suspected complex partial seizures
in Bull Terriers. Journal of the American Veterinary Medical Association.
1996;208:688-691.
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M.S., Keen, C.L., and Grivetti, L.E. Mineral values of selected plant
foods common to Southern Burkina Faso and Niamey, Niger, West Africa.
The International Journal of Food Sciences and Nutrition 1996;47:41-53.
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B., and Keen, C.L. Iron and manganese uptake by offspring of lactating
mice fed a high aluminum diet. Toxicology. 1996;109:111-118.
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B., and Keen, C.L. Aluminum alters iron and manganese uptake and regulation
of surface transferrin receptors in primary rat oligodendrocyte cultures.
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G.N., Rifkin, E., and Keen, C.L. The effects of some redox-active metals
and reactive aldehydes on DNA-protein cross-links in vitro. Toxicology.
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R.M., and Hendrickx, A.G. Adolescent growth and maturation in zinc-deprived
rhesus monkeys. American Journal of Clinical Nutrition 1996;64:274-82.
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from zinc deficient rats. Proceedings of the Society of Experimental
Biology and Medicine 1996;213:85-91.
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T.M., Rogers, J.M., Hong, K.H., and Keen, C.L. Influence of dietary
folic acid on the developmental toxicity of methanol and the frequency
of chromosomal breakage in the CD-1 mouse. Reproductive Toxicology 1996;10:455-463.
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Rogers, J.M., Fu, S.S., Connelly, L.E., and Keen, C.L. Influence of
maternal folate status on the developmental toxicity of methanol in
the CD-1 mouse. Teratology 1996;54:198-206.
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P.T., Keen, C.L., Hendrickx, A.G., and Gershwin, M.E. Activity and attention
in zinc-deprived adolescent monkeys. American Journal of Clinical Nutrition
1996;64:908-915.
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B., and Keen, C.L. Developmental patterns of aluminum and five essential
mineral elements in the central nervous system of the fetal and infant
guinea pig. Biological Trace Element Research. 1996;55: 241-251.
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Scott, K.C., Peiffer, G.L., Jang, A.M., Keyes, W.R., Keen, C.L., and
Sakanashi, T.M. Copper status of young men consuming a low-copper diet.
American Journal of Clinical Nutrition. 1997;65:72-8.
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J.M., Wiley, L.M., Clegg, M.S., and Keen, C.L. Comparative effects and
nonessential metals on preimplantation mouse embryo development in vitro.
Toxicology 1997;116:123-31.
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of zinc and copper in Bull Terriers with lethal acrodermatitis and tail-chasing
behavior. American Journal of Veterinary Research 1997;58:808-810.
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C.L., Lönnerdal, B. and Dewey, K.G. Effects of coffee consumption on
iron, zinc and copper status in nonpregnant and pregnant Sprague-Dawley
rats. The International Journal of Food Sciences and Nutrition 1997;48:177-189.
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Keen, C.L. Effects of acetaldehyde administration on tissue trace elements
and superoxide dismutase activity in rats. Environmental and Nutritional
interactions 1997;1:161-169.
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Hackman, R.M., Keen, C.L., Stern, J.S., and Gershwin M.E. Complementary
medicine: A review of immunomodulatory effects of Chinese herbal medicines.
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D., Overmann, G.J., Keen, C.L., and Daston G.P. Repeated administration
of alpha-hederin results in alterations in maternal zinc status and
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M.W., ZidenbergCherr, S., Daston, G.P., and Rogers J.M. Toxicant exposure
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and Pharmacology. 1997;N3-4: 301-308.
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1997;344: 289-294
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D.M., Wheeler, M.D., Keen, C.L., Hendricks, A.G., Moran, F. and Gershwin,
M.E. Growth retardation in premenarchial female rhesus monkeys during
chronic administration of GnRH agonist (leuprolide acetate). Journal
of Medical Primatology. 1997;26: 248-256.
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J.M., Wiley, L.M., Zidenberg-Cherr, S. and Keen, C.L. An enhancing effect
of maternal zinc deficiency and Cs y-irradiation on the frequency of
fetal malformations in mice. Teratogenesis, Carcinogenesis, and Mutagenesis.
1997;17: 127-137
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M.W., Keen, C.L., and Gonzalez, F.J. Di(2-ethylhexyl) phthalate induces
a functional zinc deficiency during pregnancy and teratogenesis that
are independent of peroxisome proliferator-activated receptor-a. Teratology.
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J.Y., Clegg, M.S., Keen, C.L. and Rucker, R.B. Incorporation of copper
into lysyl oxidase. Biochemistry Journal. 1997;327:283-289.
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T.M., Keen, C.L. and Finegood, D.T. High fructose intake significantly
reduces kidney copper concentrations in diabetic, islet transplanted
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T., Clegg, M.S., Uriu-Hare, J.Y. and Keen, C.L. Copper, lysyl oxidase
and extracellular matrix protein cross-linking. American Journal of
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J.Y., Hawk, S.N., Jankowski, M.A., Daston, G.P., Kwik-Uribe, C.L. and
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pregnancy outcome. American Journal of Clinical Nutrition. 1998;67:1003S-1011S.
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diabetic rats: reversal by insulin administration. American Journal
of Physiology-Regulatory Integrative and Comparative Physiology 1998;43:N5:R1482-R1491.
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CL, Stern JS, Uriu-Hare JY. Copper deficiency and arachidonic acid enhance
insulin secretion in isolated pancreatic islets from lean (FaFa) Zucker
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SM, Monaco MH, Baly DL, Ensuna JL, and Keen CL. The influence of manganese
deficiency on serum IGF-1 and IGF binding proteins in the male rat.
Proceedings of the Society of Experimental Biology and Medicine 1998;219:41-47.
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C, Commisso J, Killip D Ou, C-N, Rognerud CL, Dennis K and Dunn JK.
The effect of a marathon run on plasma and urine mineral and metal concentrations.
Journal of the American College of Nutrition 1998;17:124-127.
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de Water J, Kenny TP, Keen CL, Stern, JS, Hackman RM, Gershwin ME. Comparative
effects of three species of ginseng on human peripheral blood lymphocyte
proliferative responses. International Journal of Immunotherapy 1998;14:143-152.
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Keen CL, Golub MS and Oteiza PI. Membrane composition can influence
the rate of Al 3+, mediated lipid oxidation: effect of galactolipids.
Biochemical Journal 1998;333:833-838.
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MW, Muniz J, Hanna LA, Strong PL, Murray FJ, Nielsen FH, Hunt CD, and
Keen CL. Assessing the effects of low boron diets on embryonic and fetal
development in rodents using in vitro and in vivo model systems. Biological
Trace Element Research 1998;66:271-298.
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Lee JY, Hong KL, King JC, Keen CL. Serum extracellular superoxide dismutase
activity as an indicator of zinc status in humans. Biological Trace
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CL, and Ansari AA, Gershwin ME. Nutrition and the immune system. In:
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JL, Watson MH, Baly DL, Donovan SM, Monaco M, Clegg MS. Nutritional
aspects of manganese from experimental studies. Neurotoxicology 1999;20:213-224.
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CL, DiSilvestro RA, Eskelson CD, Ireton J, Hunter GC. Antioxidant enzyme
activity in human abdominal aortic aneurysmal and occlusive disease.
The Proceedings of the Society for Experimental Biology and Medicine
1999;220:39-45.
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SJ, Keen CL, Gershwin ME. Cytokines, Chemokines, and Their Cognate Receptors
in Autoimmune Diseases. Seminars in Clinical Immunology 1999;2: 17-39.
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Mizuno Y, Johnston KE, Keen CL. Folate and homocysteine metabolism in
copper-deficient rats. Biochimica Et Biophysica Acta 1999;1427: 351-356.
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J, Keen CL, Stern JS, Hackman, R, Gershwin ME. Two mushrooms, Grifola
Frondosa and Ganoderm Lucidum, can stimulate cytokine gene expression
and proliferation in human T lymphocytes. International Journal of Immunotherapy
1999;15:13-22.
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ME, Keen CL. Behavioral and hematological consequences of marginal iron-zinc
nutrition in adolescent monkeys and the effect of a powdered beef supplement.
American Journal of Clinical Nutrition 1999;70:1059-1068.
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Effects of dietary aluminum on pubertal mice. Neurotoxicology and Teratology
1999;21: 595-602.
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PL, Keen CL. Adverse effects of a low boron environment on the preimplantation
development of mouse embryos in vitro. Journal of Trace Elements in
Experimental Medicine 1999;12: 235-250.
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JL, Clegg MS. Manganese Metabolism in Animals and Humans Including the
Toxicity of Manganese. In: Metal Ions in Biological Systems, Volume
37: Manganese and its role in biological processes (Sigel A, Sigel H,
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Influence of dietary carbohydrate on zinc deficiency induced changes
in oxidative defense mechanisms and tissue oxidative damage in rats.
Biological Trace Element Research 1999;70: 81-96.
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Patterns of vitamin/mineral supplement usage by adolescents attending
athletic high schools in Korea. International Journal of Sports Nutrition
1999;9:391-405.
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VN, Keen CL. Cadmium-induced testes oxidative damage in rats can be
influenced by dietary zinc intake. Toxicology 1999;137: 13-22.
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N, Geiger C, Keen C, King J, McDonald J, Miller S, Murphy S, Schmitz
H, Shaw A, Tong P, Weaver C. Food Choices for the 21st Century. Journal
of Nutraceuticals, Functional & Medical Foods 1999;1(4): 89-95.
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Keen CL, Gershwin ME. The Influence of Chronic Yogurt Consumption on
Immunity. Journal of Nutrition 1999;129: 1492S-1495S.
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TL, Stover EL, Strong PL, Murray FJ, Keen CL. Chronic feeding of a low
boron diet adversely affects reproduction and development in Xenopus
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Van de Water J, Keen CL, Schmitz HH, Gershwin ME. The influence of cocoa
procyanidins on the transcription of interleukin-2 in peripheral blood
mononuclear cells. International Journal of Immunotherapy 1999;15: 23-29.
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BR, Mitchell AE, Cui CT, Clegg M, Kosonen T, Uriu-Adams JY, Tchaparian
EH, Fishman M, Keen CL. Activation of Chick Tendon Lysyl Oxidase in
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JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors and immunity.
The Proceedings of the Society for Experimental Biology and Medicine
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immature mice one hour after oral exposure to gold mine tailings. Environmental
Geochemistry and Health 1999;21:199-209.
- Golub MS, Keen CL,
and Gershwin ME. Moderate Zinc-Iron Deprivation Influences Behavior
but Not Growth in Adolescent Rhesus Monkeys. The Journal of Nutrition
2000;130: 354S-357S.
- Golub MS, Han B,
Keen CL. Aluminum uptake and effects on transferrin mediated iron uptake
in primary cultures of rat neurons, astrocytes and oligodendrocytes.
Neurotoxicology 1999;20: 961-970.
- Rucker RB, Cui CT,
Tchaparian EH, Mitchell AE, Clegg M, Uriu-Hare JY and Keen CL. Dietary
vanadium, P-atpase-7A expression and the influence on lysyl oxidase
and CU accumulation in rat skin and liver. Trace Elements in Man and
Animals 2000 ;52:186-187
- Rucker RB, Cui CT,
Tchaparian EH, Mitchell AE, Clegg M, Uriu-Hare JY, Rucker B, Stites
T and Keen CL. Dietary copper, vanadate, lysyl oxidase activity, and
lysine tyrosyl quinone formation. Trace Elements in Man and Animals
2000;291:929-932.
- Lanoue L, Murray
FJ, Strong PL, and Keen CL. Adverse in vitro development of preimplantation
mouse embryos exposed to low boron diet and low boron. Trace Elements
in Man and Animals 2000;332:1083-1084.
- Uriu-Adams JY, Horwath
BJ, Murray FJ, Downing G, Strong P, and Keen CL. The temporal effects
of low dietary boron (B) on tissue B concentrations in rats. Trace Elements
in Man and Animals 2000;333:1085-1086.
- Keen CL, Ensunsa
JL, Clegg MS. Manganese metabolism in animals and humans including the
toxicity of manganese. Metal Ions in Biological Systems 2000;37: 89-121.
- Bearden MM, Pearson
DA, Rein D, Chevaux KA, Carpenter DR, Keen CL. Potential Cardiovascular
Health Benefits of Procyanidins Present in Chocolate and Cocoa. In:
Parliament TH, Ho C-T, Schieberle P (eds.). Caffeinated Beverage Health
Benefits, Physiological Effects, and Chemistry. Washington, DC: American
Chemical Society 177-187. 2000.
- Hong KH, Keen CL,
Mizuno Y, Johnston KE, Tamura T. Effects of dietary zinc deficiency
on homocysteine and folate metabolism in rats. Journal of Nutrition
and Biochemistry 2000;11: 165-169.
- Tchaparian EH, Uriu-Adams
JY, Keen CL, Mitchell AE and Rucker RB. Lysyl oxidase and P-ATPase-7A
expression during embryonic development in the rat. Archives of Biochemistry
and Biophysics 2000;379: 71-77.
- Mao TK, Powell JJ,
Van de Water J, Keen CL, Schmitz HH, Hammerstone JF, Gershwin ME. The
effect of cocoa procyanidins on the transcription and secretion of interleukin-1ß
in peripheral blood mononuclear cells. Life Sciences 2000;66: 1377-1386.
- Rein D, Paglieroni
TG, Wun T, Pearson DA, Schmitz HH, Gosselin R, and Keen CL. Cocoa inhibits
platelet activation and function. American Journal of Clinical Nutrition
2000;72:30-5.
- Gershwin ME, Borchers
AT, and Keen CL. Phenotypic and Functional Considerations in the Evaluation
of Immunity in Nutritionally Compromised Hosts. The Journal of Infectious
Diseases. 2000;182: S108-S114.
- Oteiza PI, Clegg
MS, Zago MP and Keen CL. Zinc deficiency induces oxidative stress and
AP-1 activation in 3T3 cells. Free Radical Biology & Medicine 2000;28:
1091-1099.
- Rein D, Paglieroni
TG, Pearson DA, Wun T, Schmitz HH, Gosselin R, and Keen CL. Cocoa and
wine polyphenols modulate platelet activation and function. The Journal
of Nutrition 2000;130: 2120S-2126S.
- Rein D, Lotito S,
Holt RR, Keen CL, Schmitz HH, and Fraga CG. Epicatechin in human plasma:
in vivo determination and effect of chocolate consumption on plasma
oxidation status. The Journal of Nutrition 2000;130: 2109S-2114S.
- Wang JF, Schramm
DD, Holt RR, Ensunsa JL, Fraga CG, Schmitz HH, and Keen CL. A Dose-dependent
effect from chocolate consumption on plasma epicatechin and oxidative
damage. The Journal of Nutrition 2000;130: 2114S-2119S.
- Mao T, Van de Water
J, Keen CL, Schmitz HH, and Gershwin ME. Cocoa procyanidins and human
cytokine transcription and secretion. The Journal of Nutrition 2000;130:
2100S-2104S.
- Golub MS, Keen CL,
and Gershwin ME. Moderate zinc-iron deprivation influences behavior
but not growth in adolescent rhesus monkeys. The Journal of Nutrition
2000;130: 354S-357S.
- Borchers AT, Keen
CL, Stern JS, and Gershwin ME. Inflammation and Native American Medicine:
The role of botanicals. The American Journal of Clinical Nutrition 2000;72:
339-347.
- Hirschi KK and Keen
CL. Nutrition in embryonic and fetal development. Nutrition 2000;16:
495-499.
- Kwik-Uribe CL, Golub
MS, and Keen CL. Chronic marginal iron intakes during early development
in mice alter brain iron concentrations and behavior despite postnatal
iron supplementation. The Journal of Nutrition 2000;130: 2040-2048.
- Jankowski-Hennig
MA, Clegg MS, Daston GP, Rogers JM, and Keen CL. Zinc deficient rat
embryos have increased caspase 3-like activity and apoptosis. Biochemical
and Biophysical Research Communications 2000;271: 250-256.
- Borchers AT, Keen
CL, Hannum S, and Gershwin ME. Cocoa and Chocolate: Composition, bioavailability,
and health implications. Journal of Medicinal Food 2000;3: 77-105.
- Borchers AT, Sakai
S, Henderson GL, Harkey MR, Keen CL, Stern JS, Terasawa K, and Gershwin
ME. Shosaiko-To and Other Kampo (Japanese Herbal) Medicines: A review
of their immunomodulatory activities. Journal of Ethnopharmacology 2000;73:
1-13.
- Gospe SM, Caruso
RD, Clegg MS, Keen CL, Pimstone NR, Ducore JM, Gettner SS, and Kreutzer
RA. Paraparesis, hypermanganesemia and polycythemia: a novel presentation
of cirrhosis. Archives Of Disease in Childhood 2000;83:439-442.
- Golub MS, Germann
SL, Han B, Keen CL. Lifelong Feeding of a High Aluminum Diet to Mice.
Toxicology 2000;150: 107-117.
- Mao TK, Powell JJ,
Van de Water J, Keen CL, Schmitz HH, and Gershwin ME. The Effect of
Cocoa Procyanidins on the Secretion of Interleukin-4 in Peripheral Blood
Mononuclear Cells. Journal of Medicinal Food 2000;3: 107-114.
- Borchers AT, Keen
CL, Shoenfeld Y, and Gershwin ME. How to Outfox Mother Nature: Autoimmunity:
Moving from Shadows to Sunshine. Israel Medical Association Journal
2000;2:15-22.
- Keen CL and Osburn
B. We are what we eat: Ensuring safe and healthy food in the 21st century.
[editorial overview]. California Agriculture 2000;54:4-7.
- Keen CL and Zidenberg-Cherr
SA. What are the best strategies for achieving optimal nutrition? California
Agriculture 2000;54:12-18.
- Zidenberg-Cherr
S, Neyman M, Fechner K, Sutherlin J, Johns M, Lamp C, Garrett C, and
Keen CL. Nutrition may influence toxicant susceptibility children elderly.
California Agriculture 2000;54:19-25
- Borchers AT, Keen
CL, Stern JS, and Gershwin ME. Nutraceuticals: Separating chaff from
grain. California Agriculture 2000;54:26-32.
- Lotito SB, Actis-Goretta
L, Renart ML, Caligiuri M, Rein D, Schmitz HH, Steinberg FM, Keen CL,
and Fraga CG. Influence of oligomer chain length on the antioxidant
activity of procyanidins. Biochemical and Biophysical Research Communications
2000;276: 945-951.
- Lomer MCE, Thompson
RPH, Commisso J, Keen CL and Powell JJ. Determination of titanium dioxide
in foods using inductively coupled plasma optical emission spectrometry.
Analyst 2000;125:2339-2343.
- Burke KE, Clive
J, Combs GF, Commisso J, Keen CL, Nakamura RM. The effects of topical
and oral vitamin E on pigmentation and skin cancer induced by ultraviolet
irradiation in Skh:2 hairless mice. Nutrition and Cancer 2000;38:87-97.
- Pearson DA, Schmitz
HH, Lazarus SA, Keen CL. Inhibition of in vitro low-density lipoprotein
oxidation by oligomeric procyanidins present in chocolate and cocoa.
Methods of Enzymology 2001;335:350-361
- 448. 2001 Schramm
DD, Wang JF, Holt RR, Ensunsa JL, Gonsalves JL, Lazarus SA, Schmitz
HH, and Keen CL. Chocolate procyanidins decrease the leukotriene-prostacyclin
ratio in humans and human aortic endothelial cells. American Journal
of Clinical Nutrition 73:36-40.
- Oteiza, PI, Clegg
MS, Keen CL. Short-term zinc deficiency affects NF-KB nuclear binding
activity in rat testes. Journal of Nutrition 2001;131:21-26.
- Keen CL. Chocolate:
food as medicine/medicine as food. Journal of American College Nutrition.
2001;(5 Suppl):436S-439S; discussion 440S-442S.
- Tanaka A, Borchers
AT, Ishibashi H, Ansari AA, Keen CL and Gershwin ME. Genetic and familial
considerations of primary biliary cirrhosis. American Journal of Gastroenterology
2001;96:8-15.
- Uriu-Adams JY, Reece
CK, Nguyen LK, Horvath BJ, Nair R, Barter RA and Keen CL. Effect of
butyl benzyl phthalate on reproduction and zinc metabolism. Journal
of Toxicology 2001;159:55-68.
- Satre MA, Jessen
KA, Clegg MS and Keen CL. Retinol-binding protein expression is induced
in HEPG2 cells by zinc deficiency. FEBS Letters 2001;491:266-71.
- Fraga CG, Hammerstone
JF, Lazarus SA, Schmitz H and Keen CL. More antioxidants in cocoa. Journal
of Nutrition 2001;131:835.
- Tamura T, Olin KL,
Goldenberg RL, Johnston KE, DuBard MB, and Keen CL. Plasma extracellular
superoxide dismutase activity in healthy pregnant women is not influenced
by zinc supplementation. Biological Trace Element Research 2001;80:1-7.
- Duffy JY, Miller
CM, Rutschiling GL, Ridder GM, Clegg MS, Keen CL and Daston GP. A decrease
in intracellular zinc level precedes the detection of early indicators
of apoptosis in HL-60 cells. Apoptosis 2001;6:161-172
- Kim SH, Han JH,
Ed M. and Keen CL. Vitamin and mineral supplement use by healthy teenagers
in Korea: Motivating factors and dietary consequences. Nutrition 2001;17:373-380.
- Mao TK, Van de Water
J, Keen CL, Osburn BO, Silva JS Jr., and Gershwin ME. Effects of a Combination
of Traditional Chinese Botanicals (Immune+) on the Secretion of Interleukin-1b
and Interferon-g by Peripheral Blood Mononuclear Cells. Journal of Medicinal
Food 2001;4:1-8.
- Dressendorfer RH,
Petersen SR, Moss Lovshin SE, and Keen CL. Mineral Metabolism in Male
Cyclists During High-Intensity Endurance Training. International Journal
of Sport Nutrition and Exercise Metabolism 2002;12:63-72.
- Kris-Etherton PM
and Keen CL. Evidence that the Antioxidant Flavonoids in Tea and Cocoa
are Beneficial for Cardiovascular Health. Current Opinion in Lipidology
2002;13:41-49.
- Zhu QY, Holt RR,
Lazarus SA, Ensuna JL, Hammerstone JF, Schmitz HH and Keen CL. Stability
of the Flavan-3-ols Epicatechin and Catechin and Related Dimeric Procyanidins
Derived from Cocoa. Journal of Agricultural and Food Chemistry 2002;50:6:1700-1705.
- Corlett JL, Clegg
MS, Keen CL, and Grivetti LE. Mineral Content of Culinary and Medicinal
Plants Cultivated by Hmong Refugees Living in Sacramento, California.
International Journal of Food Science and Nutrition 2002;53:117-128.
- Holt RR, Schramm
DD, Keen CL, Lazarus SA, and Schmitz HH. Flavonoid-Rich Chocolate and
Platelet Function. Journal of the American Medical Association 2002;287:2212-3.
- Zhu QY, Holt RR,
Lazarus SA, Orozco TJ, and Keen CL. Inhibitory Effects of Cocoa Flavonols
and Procyanidin Oligomers on Free Radical-Induced Erythrocyte Hemolysis.
Experimental Biology and Medicine 2002;227:321-329.
- Kim SH and Keen
CL. Vitamin and mineral supplement use among children attending elementary
schools in Korea: A survey of eating habits and dietary consequences.
Nutrition Research 2002;22:433-448.
- Borchers AT, Keen
CL, and Gershwin ME. The Influence of Yogurt/Lactobacillus on the Innate
and Acquired Immune Response. Clinical Reviews in Allergy and Immunology
2002;22:207-230.
- Golub MS, Zhang
W, Keen CL, and Goldkorn T. Cellular Action of A1 at Low (1.25 mM) Concentrations
in Primary Oligodendrocyte Culture. Brain Research 2002;94:82-90.
- Mao, T.K., Van de
Water, J., Keen, C.L., Schmitz, H.H. and Gershwin, M.E. The effect of
cocoa flavanols and their related oligomers on the secretion of interleukin-5
in peripheral blood mononuclear cells. Journal of Medicinal Foods 2002;5:17-22.
- Hannum, S.M., Schmitz, H.H.
and Keen, C.L. Chocolate: a heart-healthy food? show me the science!
Nutrition Today 2002;37:3:103-109.
- Holt, R.R., Lazarus, S.A.,
Sullards, M.C., Zhu, Q.Y., Schramm, D.D., Hammerstone, J.F., Fraga,
C.G., Schmitz, H.H. and Keen, C.L. Procyanidin dimer B2 (The epicatechin-(4b-8)-epicatechin)
in human plasma after the consumption of a flavonol-rich cocoa. The
American Journal of Clinical Nutrition 2002;76:798-804.
- Mackenzie, G.G., Zago, M.P.,
Keen, C.L. and Oteiza, P.I. Low intracellular zinc impairs the translocation
of activated NF-?B to the nuclei in human neuroblastoma IMR-32 cells.
Journal of Biological Chemistry 2002;277:34610-34617.
- Pearson, D.A., Paglieroni,
T.G., Rein, D., Wun, T., Schramm, D.D., Wang, J.F.,Holt, R.R., Gosselin,
R., Schmitz, H.H. and Keen, C.L. The effects of flavoanol-rich cocoa
and aspirin on ex vivo platelet function. Thrombosis Research 2002;106:191-197.
- Borchers, A.T., Keen, C.L.
and Gershwin, M.E. Microgravity and immune responsiveness: implications
for space travel. Nutrition 2002;18:889-898
- Mackenzie GG, Keen CL and
Oteiza PI. Zinc status of human IMR-32 neuroblastoma cells influences
their susceptibility to iron-induced oxidative stress. Developmental
Neuroscience 2002;24:125-133.
- Zhu QY, Hackman RM, Ensunsa
JL, Holt RR, and Keen CL. Antioxidant activities of oolong tea. Journal
of Agricultural and Food Chemistry 2002;50:6929-6934.
- Pearson DA, Paglieroni TG,
Rein D, Wun T, Schramm DD, Wang JF, Holt RR, Gosselin R, Schmitz HH
and Keen CL. The effects of flavanol-rich cocoa and aspirin on ex vivo
platelet function. Thrombosis Research 2002;106:191-197
- Ottaviani JI, Carrasquedo
F, Keen CL, Lazarus SA, Schmitz HH, and Fraga CG. Influence of flavan-3-ols
and procyanidins on UVC mediated formation of 8-Oxo-7, 8-dehydro-2’-deoxyguanosine
in isolated DNA. Archives of Biochemistry and Biophysics 2002;406:203-208.
- Steinberg FM, Holt RR, Schmitz
HH, and Keen CL. Cocoa procyanidin chain length does not determine ability
to protect LDL from oxidation when monomer units are controlled. The
Journal of Nutrition Biochemistry 2002;13:645-652.
- Borchers AT, Keen CL, Shoenfeld
Y, Silva JS, and Gershwin ME. Vaccines, viruses, and voodoo. Journal
of Investigative Allergology and Clinical Immunology 2002;12:155-168.
- Keen CL, Holt RR, Polagruto
JA, Wang JF, and Schmitz HH. Cocoa flavanols and cardiovascular health.
Phytochemical Reviews 2002;1:231-240.
- Mao TK, Van De Water J, Keen
CL, Schmitz HH, and Gershwin ME. Modulation of TNF-alpha secretion in
peripheral blood monocular cells by cocoa flavanols and procyanidins.
Developmental Immunology 2002;9:135-41
- Verstraeten SV, Keen CL,
Schmitz HH, Fraga CG, and Oteiza PI. Flavan-3-ols and procyanidins protect
liposomes against lipid oxidation and disruption of the bilayer structure.
Free Radical Biology and Medicine 2003;34:84-92.
- Mao TK, Van De Water J, Keen
CL, Schmitz HH, and Gershwin ME. Cocoa. flavanols and procyanidins promote
TGF –$1 homeostasis in peripheral blood mononuclear cells. Experimental
Biology and Medicine 2003;228: 93-99.
- Zhu QY, Hammerstone JF, Lazarus
SA, Schmitz HH, and Keen CL. Stabilizing effect of ascorbic acid on
flavan-3-ols and dimeric procyanidins from cocoa. Journal of Agricultural
and Food Chemistry 52003;1: 828-833.
- Steinberg FM, Bearden MM, and Keen CL. Cocoa and chocolate flavonoids:
Implications for cardiovascular health. Journal of the American Dietetic
Association 2003;103:215-223.
- Kim SH, Kim, JS, Shin, HS
and Keen CL. Influence of smoking on markers of oxidative stress and
serum mineral concentrations in teenage girls in Korea. Nutrition 2003;19:240-243.
- Schramm DD, Karim M, Schrader
HR, Holt RR, Cardetti M, and Keen CL. Honey with high levels of antioxidants
can provide protection to healthy human subjects. Journal of Agricultural
and Food Chemistry 2003;12:1732-1735.
- Hawk SN, Lanoue L, Keen CL,
Kwik-Uribe CL, Rucker RB, and Uriu-Adams JY.
Copper deficient rat embryos are characterized by low superoxide dismutase
activity and elevated superoxide anions. Biology of Reproduction 2003;68:896-903.
- Orozco TJ, Wang JF, and Keen
CL. Chronic consumption of a flavanol and procyanindin-rich diet is
associated with reduced levels of 8-hydroxy-2’-deoxyguanosine
in rat testes. Journal of Nutritional Biochemistry 2003;14:104-110.
- Golub MS, Germann SL,and
Keen CL. Developmental aluminum toxicity in mice can be modulated by
low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the diet. Biological
Trace Element Research 2003;93: 213-226.
- Keen CL, Clegg MS, Hanna
LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, and Uriu-Adams JY. The
plausibility of micronutrient deficiencies being a significant contributing
factor to the occurrence of pregnancy complications. The Journal of
Nutrition 2003;133:1597S-1605S.
- Schramm DD, Karim M, Polagruto
JA, Schrader HR, Holt RR, Kirkpatrick NJ, Ensunsa JL, Schmitz HH, and
Keen CL. Food effects on the absorption and pharmacokinetics of cocoa
flavanols. Life Sciences 2003;73: 857-869.
- Leazer TM, Daston GP, Keen
CL, and Rogers JM. The embryolethality of lipopolysaccharide in CD-1
and metallothionein I-II null mice: lack of a role for induced zinc
deficiency or metallothionein induction. Toxicological Sciences 2003;73:
442-447.
- Borchers A, Naguwa S, Keen
C, and Gershwin M. Immunopathogenesis of sjogren’s syndrome.Clinical
Review in Allergy and Immunology 2003;25:89-104.
- Kim SH, Han JH, Zhu QY, and
Keen CL. Use of vitamins, minerals, and other dietary supplements by
17- and 18-year-old students in Korea. Journal of Medicinal Foods 2003;6:27-42.
- Keen CL, Jue T, Tran CD,
Vogel J, Downing RG, Iyengar V, and Rucker RB. Analytical methods: improvements,
advancements and new horizons. The Journal of Nutrition 2003;133:1574S-1578S
- Keen CL, Hanna LA, Lanoue
L, Uriu-Adams J, Rucker RB, and Clegg MS. Developmental consequences
of trace mineral deficiencies in rodents: Acute and long-term effects.
The Journal of Nutrition 2003;133:1477S-1480S
- Hanna LA, Clegg MS, Momma
TY, Daston GP, Rogers JM, and Keen CL. Zinc influences the in vitro
development of peri-implantation mouse embryo. Birth defects research
part A: Clinical and Molecular Teratology 2003;67:414-420.
- Fraga CG and Keen CL. Flavanols
and procyanidins as modulators of oxidation in vitro and in vivo. In:
Free Radicals, Nitric Oxide and Inflammation: Molecular, Biochemical
and Clinical Aspects. NATO-ASI Series IOS Press 2003;344:24-33.
- Keen CL, Holt RR, Carrasquedo
F, Gershwin ME, Mao TK, and Schmitz HH. Flavanol-rich foods and cardiovascular
health. In: Frontiers in Cardiovascular Health (N.S. Dhalla, A Chockalingam,
H.I. Berkowitz, P.K. Singal eds) 209-226. 2003.
- Borchers AT, So C, Naguwa
SM, Keen Cl, and Gershwin ME. Clinical and immunologic components of
sarcodoisis. Clinical Review in Allergy 2003;25: 289-394.
- Tomkins A, Davies C, Goldenberg
R, Jackson A, Keen C, King J and Nestel P. Nutrition as a preventative
strategy against adverse maternal pregnancy outcomes – a USAID/Wellcome
Trust Workshop at Merton College, Oxford, UK, 18-19 July 2002 (commentary).
Public Health Nutrition 2003;6:629-630.
- Borchers AT, Keen CL and
Gershwin ME. Use and misuse of corticosteroids. Comprehensive Therapy
2003;29:157-165.
- Actis-Goretta L, Ottaviani
JI, Keen CL and Fraga CG. Inhibition of angiotensin converting enzyme
(ACE) activity by flavan-3-ols and procyanidins. FEBS Letters 555:597-600.
2003.
- Schroeter H, Holt RR, Orozco
TJ, Schmitz HH and Keen CL. Milk and absorption of dietary flavanols.
Nature 2003;426: 787-788.
- Wang JF, Lazarus SA, Schmitz
HH and Keen CL. The role of flavonols and their related oligomers in
cardiovascular health. In: Shahidi F., Weerasinghe DK, (eds). Nutraceutical
Beverages, Chemistry, Nutrition, and Health Effects. ACS Symposium Series
2004;871:237-253.
- Polagruto JA, Schramm DD,
Wang-Polagruto JF, Lee L, and Keen CL. Effects of flavonoid-rich beverages
on prostacyclin synthesis in humans and human aortic endothelial cells:
association with ex vivo platelet function. Journal of Medicinal Foods
2004;6:301-308.
- Keen CL, Hanna LA, Yang SJ,
Lanoue L, Uriu-Adams JY, Rucker RB, Andersen H, and McArdle H. Developmental
toxicology of copper deficiency and excess. In: Lagos GE, Warner AEM,
and Sanchezs M, (eds). Copper, Environment and Sustainable Development.
Vol.2 Met Soc Publications. Montreal, Canada 401-414, 2004.
- Verstraeten SV, Zago MP,
Mackenzie GG, Keen CL, and Oteiza PI. Influence of zinc deficiency on
cell membrane fluidity in Jurkat 3T3, and IMR-32 cells. Biochemical
Journal 2004;378:579-587.
- Uriu-Adams JY, Keen CL. The
influence of maternal nutrition on phthalate teratogenicity. In: Wypych,
G (eds). Handbook of Plasticizers. ChemTech Publishing, Ontario, Canada
545-556, 2004.
- Mackenzie GG, Carrasquedo
F, Delfino JM, Keen CL, Fraga CG, and Oteiza PI. Epicatechin, catechin
and dimeric procyanidins inhibit PMA-induced NF-?B activation at multiple
steps in Jurkat T cells. FASEB Journal 2004;18:167-169.
- Kenny TP, Keen CL, Jones
P, Kung HJ, Schmitz HH, and Gershwin ME. Pentameric procyanidins isolated
from Theobroma cacao seeds selectivity down-regulate ErbB2 in human
aortic endothelial cells. Experimental Biology and Medicine 2004;229:255-263.
- Borchers AT, Mao TK, Keen
CL, Schmitz HH, and Watanabe H. Traditional Asian medicine and oral
health. Journal of Traditional Medicine 2004;21:17-26.
- Borchers AT, Keen CL, and
Gershwin ME. Mushrooms, tumors and immunity: An update: Experimental
Biology and Medicine 2004;229:393-406.
- Duffy JY, Overmann GJ, Keen
CL, Clegg MS, and Daston GP. Cardiac Abnormalities induced by zinc deficiency
are associated with alterations in the expression of genes regulated
by the zinc-finger transcription factor GATA-4. Birth Defects Research
Part B: Developmental and Reproductive Toxicology 2004;71:102-109.
- Kim SH, Ensunsa JL, Zhu QY,
Kim JS, Shin HS, and Keen CL. An eighteen- month follow-up study on
the influence of smoking on blood antioxidant status of teenage girls
in comparison to male adult smokers in Korea. Nutrition 2004;20:437-444.
- Turnlund JR, Jacob RA, Keen
CL, Strain JJ, Kelley DS, Domek JM, Keyes WR, Ensunsa JL, Lykkesfeldt
J, and Coulter J. Long-term high copper intake: effects on indices of
copper status, antioxidant status, and immune function in young men.
American Journal of Clinical Nutrition 2004;79:1037-1044.
- Kris-Etherton PM, LeFevre
M, Beecher GR, Gross MD, Keen CL, Etherton TD. Bioactive compounds in
nutrition and health research methodologies for establishing biological
function: The antioxidant and anti-inflammatory effects of flavonoids
on atherosclerosis. Annual Reviews of Nutrition 2004;24:511-538.
- Keen CL, Uriu-Adams JY, Ensuna
JL, and Gershwin ME. Trace elements/minerals and immunity. In: Handbook
of Nutrition and Immunity. (ME Gershwin; P. Nestle; CL Keen; editors).
Humana Press, Totowa, New Jersey, 2004, 117-140.
- Borchers AT, Keen CL, and
Gershwin ME. Probiotics and prebiotics. In: Handbook of Nutrition and
Immunity. (ME Gershwin; P. Nestle; CL Keen; editors). Humana Press,
Totowa, New Jersey, 2004, 213-242.
- Cui CT, Uriu-Adams JY, Tchaparian
EH, Keen CL, and Rucker RB. Metavanadate causes cellular accumulation
of copper and decreased lysyl oxidase activity. Toxicology and Applied
Pharmacology 2004;199:35-43.
- Kenny TP, Jones P, Kung H-J,
Schmitz HH and Keen CL. Cocoa procyanidins inhibit proliferation and
angiogenic signals in human dermal microvascular endothelial cells following
stimulation by low level H2O2. Experimental Biology and Medicine 2004;229:255-263.
- Borchers AT, Keen CL, Cheema
GS, and Gershwin ME. The use of methotrexate in rheumatoid arthritis.
Seminars in Arthritis and Rheumatology 2004;34:465-483.
- Oberbauer AM, Stiglich C,
Murray JD, Keen CL, Fong DL, Smith LB, and Cushwa S. Dissociation of
body growth and adipose deposition effects of growth hormone in oMtla-oGh
Transgenic mice. Growth Development and Aging 2004;68:33-45.
- Borchers AT, Keen CL, Shoenfeld
Y, and Gershwin ME. Surviving the butterfly and the wolf: Mortality
trends in systemic lupus erythematosus. Autoimmunity Reviews 2004;3:423-453.
- Chou SS, Clegg MS, Momma
TY, Niles BJ, Duffy JY, Daston GP, and Keen CL. Alterations in protein
kinase C activity and processing during zinc deficiency-induced cell
death. Biochemical Journal 2004;383:63-71.
- Ensunsa JL, Symons DJ, Lanoue L, Schrader HR, and Keen CL. Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Experimental Biology and Medicine. 2004;229:1143-1153.
- Borchers AT, Naguwa SM, Keen CL and Gershwin, ME. The diagnosis and management of anaphylaxis. Comprehensive Therapy. 2004;30:111-120.
- Borchers AT, Keen CL and Gershwin, ME. Fatalities following allergen immunotherapy. Clinical Reviews in Allergy and Immunology. 2004;27:147-158.
- Keen CL, Holt RH, Oteiza PI, Fraga CG and Schmitz HH. Cocoa antioxidants and cardiovascular health. American Journal of Clinical Nutrition. 81:2985-3035, 2005
- Fraga CG, Actis-Goretta L, Ottaviani JI, Carrasquedo F, Lotito SB, Lazarus S, Schmitz HH and Keen CL. Regular consumption of a flavanol rich chocolate can improve oxidant stress in young soccer players. Clinical and Developmental Immunology. 12:11-17, 2005.
- Zhu QY, Schramm DD, Gross HB, Holt RH, Kim SH, Yamaguchi T, Kwik-uribe CL, and Keen Cl. Influence of cocoa flavanols and procyanidins of free-radical-induced human enytrocyte hemolysis. Clinical and Developmental Immunology. 12:27-34, 2005.
- Pearson DA, Holt RR, Rein D, Paglieroni, T. Schmitz, HH and Keen, CL. Flavanols and platelet reactivity. Clinical and Developmental Immunology. 12: 1-9, 2005.
- Oteiza PI, Erlejman AG, Verstraeten SV, Keen CL, and Fraga CG. Flavonoid-membrane interactions: A protective role of flavonoids at the membrane surface? Clinical and Developmental Immunology. 12:19-25, 2005.
- Kim SH, Kim JY, Ed M, and Keen CL. Comparison of dietary patterns and nutrient intakes of elementary schoolchildren living in remote rural and urban areas in Korea: their potential impact on school performance. Nutrition Research. 25:349-363, 2005.
- Borchers AT, Keen CL, and Gershwin ME. Hope for the hygiene hypothesis: When the dirt hits the fan. Journal of Asthma. 42:225-247, 2005.
- Uriu-Adams JY, Rucker RB, Commisso JF, and Keen CL. Diabetes and dietary copper alter 67 Cu metabolism and oxidant defense in the rat. Journal of Nutritional Biochemistry, 16:312-320, 2005.
- Verstraeten SV, Lanoue L, Keen CL, and Oteiza PI. Relevance of lipid polar headgroups on boron-mediated changes in membrane physical properties. Archives of Biochemistry and Biophysics, 438:103-110, 2005.
- Borchers AT, Keen CL, and Gershwin ME. Immunity. Physiological Aspects In: Encyclopedia of Human Nutrition, 2nd Edition (Caballero, B, Allen L and Prentice A, eds) Elsevier Ltd, Kidlington, Oxford, UK, Vol 3:1-6, 2005.
- Keen CL, Ensunsa JL, Lonnerdal B, and Zidenberg-Cherr S. Manganese: Physiology, dietary sources and requirements. In: Encyclopedia of Human Nutrition, 2nd Edition (Caballero, B, Allen L and Prentice A, eds) Elsevier Ltd, Kidlington, Oxford, UK, Vol 1:217-225, 2005.
- Verstraeten SV, Hammerstone JF, Keen CL, Fraga CG, and Oteiza PI. Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. Journal of Agricultural and Food Chemistry, 53:5041-5048, 2005.
- Rogers JM, Chernoff N, Keen CL, and Daston GP. Evaluation and interpretation of maternal toxicity in Segment II studies: Issues, some answers, and data needs. Toxicology and Applied Pharmacology, 207: 5367-5374, 2005.
- Borchers AT, Aoki CA, Naguwa SM, Keen CL, Shoenfeld Y, and Gershwin ME. Neuropsychiatric features of systemic lupus erythematosus. Autoimmunity Reviews, 4:329-344, 2005.
- Aoki CA, Borchers AT, Ridgway WM, Keen CL, Ansari AA, and Gershwin ME. NOD mice and autoimmunity. Autoimmunity Reviews, 4:373-379, 2005.
- Fraga CG, Oteiza PI and Keen CL. Trace elements and human health. (editorial) Molecular Aspects of Medicine, 26: 233-234, 2005.
- Uriu-Adams JY, and Keen CL. Copper, oxidative stress and human health. Molecular Aspects of Medicine, 26: 268-298, 2005.
- Zago MP, Mackenzie GG, Adamo AM, Keen CL, and Oteiza PI. Differential Modulation of MAP Kinases by Zinc Deficiency in IMR Cells: Role of H2O2. Antioxidants & Redox Signaling. 7: 1773-1782, 2005.
- Clegg MS, Hanna LA, Niles BJ, Momma TY, and Keen CL. Zinc deficiency-induced cell death. IUBMB LIFE. 57: 661 – 669, 2005.
- Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, and Oteiza PI. α-lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radical Research. 40: 75-84, 2006.
- Beckers-Trapp ME, Lanoue L, Keen CL, Rucker RB, Uriu-Adams JY. Abnormal development and increased 3-nitrotyrosine in Cu deficient mouse embryos. Free Radical Biology & Medicine. 40: 35-44, 2006.
- Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe K, Schmitz HH, and Kelm M. Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proceedings of the National Academy of Sciences. USA. 103: 1024-1029, 2006.
- Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen, CL. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. International Journal of Obesity. pp: 1-12, 2006.
- Borchers A, Keen CL, Gershwin ME. Complementary/alternative therapies in asthma. In: Current Clinical Practice: Bronchial Asthma: A Guide for Practical Understanding and Treatment. (ME Gershwin, TE Albertson, editors) Humana Press, Totowa, New Jersey, 5th edition: pp 181-199, 2006.
- Borchers A, Keen CL, Gershwin ME. Complementary/alternative therapies in asthma. In: Current Clinical Practice: Bronchial Asthma: A Guide for Practical Understanding and Treatment. (ME Gershwin, TE Albertson, editors) Humana Press, Totowa, New Jersey, 5th edition 10:1545-56, 2006.
- Ottaviani JI, Keen CL, Fraga CG. Chocolate and health: on the vascular effects of flavanols in cocoa. Agro Food Industry Hi-Tech 17:9-12, 2006.
- Borchers AT, Chang C, Keen CL, Gershwin ME. Airborne Environmental Injuries and Human Health. Clinical Reviews in Allergy & Immunology 31:1-101, 2006.
- Borchers AT, Selmi C, Cheema G, Keen CL, Shoenfeld Y, Gershwin ME. Juvenile idiopathic arthritis. Autoimmunity Reviews 5:279-298, 2006.
- Davis PA, Polagruto JA, Valacchi G, Phung A, Soucck K, Keen CL, Gershwin ME. Effects of apple extracts on NF-ĸB activation in human umbilical vein endothelial cells. Experimental Biology and Medicine 231:594-598, 2006.
- Selmi C, Mao TK, Keen CL, Schmitz HH, Gershwin ME. The anti-inflammatory properties of cocoa flavanols. Journal of Cardiovascular Pharmacology 47:S163-S171, 2006.
- Wang-Polagruto JF, Villablanca AC, Polagruto JA, Lee L, Holt, RR, Schrader HR, Ensunsa JL, Steinberg FM, Schmitz HH, and Keen CL. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. Journal of Cardiovascular Pharmacology 47:S177-S186, 2006.
- Holt RR, Actis-Goretta L, Momma TY, Keen CL. Dietary flavanols and platelet reactivity. Journal of Cardiovascular Pharmacology 47:S187-S196, 2006.
- Keen CL, Uriu-Adams JY. Assessment of zinc, copper and magnesium status: Current approaches and promising new directions. In: Mineral Requirements for Military Personnel. The National Acedemies Press. Washington DC, pp 304-315, 2006.
- Jones LC, McCarthy KA, Beard JL, Keen CL, Jones BC. Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. Nutritional Neuroscience 9:81-92, 2006.
- Ellis-Hutchings RG, Cherr GN, Hanna LA, Keen CL. Polybrominated diphenyl ether (PBDE)-induced alternations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. Toxicology Applied Pharmacology 215:135-145, 2006.
- Mackenzie GG, Keen CL, Oteiza PI. Microtubules are required for NF-ĸB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. Journal of Neurochemistry 99:402-415, 2006.
- Yang SF, Uriu-Adams JY, Keen CL, Rucker RB, Lanoue L. Effects of copper deficiency on mouse yolk sac vasculature and expression of angiogenic mediators. Birth Defects Research Part B: Developmental and Reproductive Toxicology 77:445-454, 2006.
- Polagruto JA, Wang-Polagruto JF, Braun MM, Lee L, Kwik-Uribe C, Keen CL. Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and LDL cholesterol. Journal of American Dietetic Association 106:1804-1813, 2006.
- Stern BR, Solioz M, Krewski D, Aggett P, Aw TC, Baker S, Crump K, Dourson M, Haber L, Hertzberg R, Keen CL, Meek B, Rudenko L, Schoeny R, Slout W, Starr T. Copper and human health: Biochemistry, genetics and strategies for modeling dose-response relationships. Journal of Toxicology Environmental Health Behavior B. Critical Review 10:157-222, 2006.
- Kenny TP, Keen CL, Schmitz HH, Gershwin ME. Immune affects of cocoa procyanidin oligomers on peripheral blood mononuclear cells. Experimental Biology and Medicine 232:293-300, 2007.
- Mansour M, Cheema GS, Naguwa SM, Greenspan A, Borchers AT, Keen CL, Gershwin ME. Ankylosing spondylitis: A contemporary perspective on diagnosis and treatment. Seminars in Arthritis and Rheumatism 36:210-223, 2007.
- Borchers AT, Hagie F, Keen CL, Gershwin ME. The history and contemporary challenges of the US food and drug administration. Clinical Therapeutics 29:1-16, 2007.
- Erdman JW, Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, Harnly J, Hollman P, Keen CL, Mazza G, Messina M, Scalbert A, Vita J, Williamson G, and Burrowes J. Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop May 31 – June 1, 2005, Washington, DC. The Journal of Nutrition 137:718S-737S, 2007.
- Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Stohs SJ, Stern JS and Keen CL. Response to Dr. Inchiosa (Letter to the Editor). International Journal of Obesity 31:1482-1483, 2007.
- Borchers AT, Keen CL, Gershwin ME. Drug-Induced Lupus. Ann. N.Y. Academy of Sciences New York Academy of Sciences 1108:166-182, 2007.
- Danzeisen R, Araya M, Harrison B, Keen CL, Solioz M, Thiele D, McArdle HJ. How reliable and robust are current biomarkers for copper status? British Journal of Nutrition 98:676-683, 2007.
- Hackman RM, Polagruto JA, Zhu QV, Sun B, Fujii H, Keen CL. Flavanols: digestion, absorption and bioactivity. Phytochemistry Reviews 7:195-208, 2007.
- Yang SJ, Keen CL, Lanoue L, Rucker RB, Uriu-Adams J. Low nitric oxide: a key factor underlying copper deficiency teratogenicity. Free Radical Biology & Medicine43:1639-1648, 2007.
- Seimi MN, Furlan R, Keen CL, Gershwin ME. Inflammation and oxidative stress in obstructive sleep apnea syndrome. Experimental Biology and Medicine 232:1409-1413, 2007.
- Selmi C, Bowlus CL, Keen CL, Gershwin ME. Non alcoholic fatty liver disease: the new epidemic and the need for novel nutritional approaches. Journal of Medicinal Food 10:563-565, 2007.
- Shenoy SF, Keen CL, Kalgaonkar S, Polagruto JA. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thrombosis Research121:431-432, 2007.
- Chang C, Keen CL, Gershwin ME. Treatment of eczema. Clinical Review in Allergy and Immunology 33:204-225, 2007.
- Polagruto JA, Gross, HB, Kamanger, F, Kosuna, K, Sun, B, Fujii, H, Keen CL, Hackman RM.Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. Journal of Medicinal Food 10:725-730, 2007.
- Niles BJ, Clegg MS, Hanna LA, Chou SS, Momma TY, Hong H, Keen CL. Zinc deficiency-induced iron accumulation: A consequence of alterations in iron regulatory protein binding activity, iron transporters, and iron storage proteins. Journal of Biological Chemistry. In Press
- Lopez V, Keen CL, Lanoue L. Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model. Biological Trace Element Research. In Press
Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME. The immunobiology of mushrooms. Experimental Biology and Medicine. In Press
- Gu YS, Kong J, Cheema GS, Keen CL, Wick G, Gershwin ME. The immunobiology of systemic sclerosis. Seminars in Arthritis and Rheumatism. In Press
- Actis-Goretta L, Romanczyk LJ, Rodriguez CA, Kwike-Uribe C, Keen CL. Cytotoxic effects of digalloyl dimmer procyanidins in human cancer cell lines. The Journal of Nutritional Biochemistry. In Press
- Borchers AT, Keen CL, Gershwin ME. Smoking cessation: Significance and implications for children. Clinical Review in Allergy and Immunology. In Press
- Schnorr O, Brossette T, Momma T, Kleinbongard P, Keen CL, Schroeter H, Sies H. Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo. Archives of Biochemistry and Biophysics. In Press
- Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross HB, Keen CL, Schroeter H, Kelm M. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients: A double-masked, randomized, controlled trial. Journal of the American College of Cardiology. In Press
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