The primary focus of Dr. Hanna´s work is the role of trace elements in regulating early mammalian embryo development. In collaboration with Drs. Michael Clegg and Carl Keen, she is investigating the mechanisms by which zinc status regulates signal transduction, gene transcription, mRNA translation, the cell cycle and apoptosis. In collaboration with Dr. Robert Rucker and others, she is examining the role of copper in early cell differentiation in embryonic stem cells and mouse embryos. Although her research utilizes several in vitro cell and embryo culture models, findings are also integrated with those in the whole animal using several recombinant mouse models.