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Lynn A. Hanna

Lynn A. Hanna

  • Associate in AES



  • B.S., Nutrition Science, University of California, Davis
  • Ph.D., Nutrition, University of California, Davis

Research Interests

The primary focus of Dr. Hanna´s work is the role of trace elements in regulating early mammalian embryo development. In collaboration with Drs. Michael Clegg and Carl Keen, she is investigating the mechanisms by which zinc status regulates signal transduction, gene transcription, mRNA translation, the cell cycle and apoptosis. In collaboration with Dr. Robert Rucker and others, she is examining the role of copper in early cell differentiation in embryonic stem cells and mouse embryos. Although her research utilizes several in vitro cell and embryo culture models, findings are also integrated with those in the whole animal using several recombinant mouse models.

Selected Publications

  • Niles, BJ, Clegg, MS, Hanna, LA, Chou, SS, Momma, TY, Hong, H, Keen, CL. Zinc deficiency-induced iron accumulation: A consequence of alterations in iron regulatory protein binding activity, iron transporters, and iron storage proteins. Journal of Biological Chemistry Epub ahead of press December 12th 2007.
  • Ellis-Hutchings, RG, Cherr, GN, Hanna, LA, Keen, CL. Polybrominated Diphenyl Ether (PBDE)-Induced Alterations in Vitamin A and Thyroid Hormone Homeostasis During Lactation and Postnatal Rat Development. Toxicology and Applied Pharmacology 215:135-45 (2006).
  • Clegg MS, Hanna LA, Niles BJ, Momma TY, Keen CL. Zinc deficiency-induced cell death. IUBMB Life 57:661-9, 2005.
  • Keen CL, Hanna LA, Yang SJ, Lanoue L, Uriu-Adams JY, Rucker RB. Developmental toxicology of copper deficiency and excess. Copper 2003: Health, Environment and Sustainable Development, Vol II. Eds. Lagos GE, Warner AEM, Sanchez M. Santiago, Chile. 2004
  • Hanna LA, Clegg MS, Momma TY, Rogers JM, Daston GP, Keen CL. Zinc influences the in vitro development of peri-implantation mouse embryos. Birth Defects Research: Clinical and Molecular Teratolgoy 67:414-420, 2003.
  • Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, Uriu-Adams JY. The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. Journal of Nutrition, 133:1597S-1605S, 2003.
  • Keen CL, Hanna LA, Lanoue L, Clegg MS. Developmental consequences of trace mineral deficiencies: Acute and long-term effects. Journal of Nutrition, 133:1477S-80S, 2003.
  • Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes and Development 16:2650-2661, 2002.
  • Lanuoue L, Taubeneck MW, Muniz J, Hanna LA, Strong PL, Murray FJ, Nielsen FH, Hunt CD, Keen CL. Assessing the effect of low boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems. Biological Trace Element Research 66:271-298, 1998.
  • Hanna LA, Peters JM, Wiley LM, Zidenberg-Cherr S, and Keen CL. Enhancing effect of maternal zinc deficiency and 137Cs g-irradiation on the frequency of fetal malformations in mice. Teratogenesis, Carcinogenesis, and Mutagenesis 17:127-137, 1997.
  • Hanna LA, Peters JM, Wiley LM, Clegg MS, and Keen CL. Comparative effects of essential and nonessential metals on preimplantation mouse embryo development in vitro. Toxicology 116:123-131, 1997.