Ph.D., Pharmaceutical Science, Toyama University Institute of Natural Medicine Research Center for Ethnomedicine, Division of Biofunctional Evaluation
MSc., Kyoto University Graduate School of Engineering Department of Polymer Chemistry
Dr. Fujii’s research interests are focused on the development and testing of novel botanical extracts. His current work includes research on a mushroom mycelia extract, a lychee fruit extract, and an enzyme-treated asparagus extract.
Lipase modification by various synthetic polymers for use in chloroform. Yoshihiro Ito, Hajime Fujii, Yukio Imanishi, Biotechnology Letters, 14(2): 1149-1152 (1992).
Enzyme hybridization with synthetic polymers for use in organic media. Yoshihiro Ito, Hajime Fujii, Yukio Imanishi, Macromolecular Rapid Communications, 13: 315-319 (1992).
Catalytic peptide synthesis by trypsin modified with polystyrene in chloroform. Yoshihiro Ito, Hajime Fujii, Yukio Imanishi, Biotechnology Progress, 9(2): 128-130 (1993).
Lecithinization of IL-6 enhances its thrombopoietic activity in mice. Igarashi R, Tsutsumi Y, Fujii H, Tsunoda S, Ochiai A, Takenaga M, Morizawa Y, Mayumi T, Mizushima Y., Journal of Pharmacy and Pharmacology, 49(1): 113-118 (1997).
Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Toshiaki Makino, Yasuyuki Furuta, Hajime Fujii, Takashi Nakagawa, Hannosuke Wakushima, Ken-ichi Saito, Yoshihiro Kano, Biological & Pharmaceutical Bulletin, 24(10): 1206-1209 (2001).
Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity. Takehito Miura, Lan Yuan, Buxiang Sun, Hajime Fujii, Mayumi Yoshida, Koji Wakamem, Ken-ichi Kosuna, Bioscience, Biotechnology, and Biochemistry, 66(12): 2626-2631 (2002).
Inhibition of human breast cancer growth by GCP (genistein combined polysaccharide) in xenogeneic athymic mice: involvement of genistein biotransformation by β-glucuronidase from tumor tissues. Lan Yuan, Chihiro Wagatsuma, Mayumi Yoshida, Takehito Miura, Tomomi Mukoda, Hajime Fujii, Buxiang Sun, Jung-Hwan Kim, Young-Joon Surh, Mutation Research, 523-524: 55-62 (2003).
Anti-allergic effect of Perilla frutescens and its active constituents. Toshiaki Makino, Yasuyuki Furuta, Hannosuke Wakushima, Hajime Fujii, Ken-ichi Saito, Yoshihiro Kano, Phytotherapy Research, 17(3): 240-243 (2003).
Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Yunfei Gao, Dongqing Zhang, Buxiang Sun, Hajime Fujii, Ken-Ichi Kosuna, Zhinan Yin, Cancer Immunol Immunother, 55(10): 1258-1266 (2005).
Comparative efficacy of oligonol, catechin and (-)-epigallocatechin 3-O-gallate in modulating the potassium bromate-induced renal toxicity in rats. Hiroshi Nishioka, Hajime Fujii, Buxiang Sun, Okezie I. Aruoma, Toxicology, 226: 181-187 (2006).
Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials. Okezie I. Aruoma, Buxiang Sun, Hajime Fujii, Vidushi S. Neergheen, Theeshan Bahorun, Kyung-Sun Kang, Mi-Kyung Sung, Bio Factors, 27(1-4): 245-265 (2006).
Protective effect of grape seed polyphenols against high glucose-induced oxidative stress. Hajime Fujii, Takako, Yokozawa, Young Ae Kim, Chihiro Tohda, Gen-ichiro Nonaka, Bioscience, Biotechnology, and Biochemistry, 70(9): 2104-2111 (2006).
Nutritional Food Active Hexose Correlated Compound (AHCC) Enhances Resistance against Bird Flu. Hajime Fujii, Hiroshi Nishioka, Koji Wakame, Buxiang Sun, Japanese Journal of Complementary and Alternative Medicine, 4(1): 37-40 (2007).
The influence of active hexose correlated compound (AHCC) on cisplatin-evoked chemotherapeutic and side effects in tumor-bearing mice. Aya Hirose, Eri Sato, Hajime Fujii, Buxiang Sun, Hiroshi Nishioka, Okezie I. Aruoma, Toxicology and Applied Pharmacology, 222: 152-158 (2007).
A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. Egilius L. H. Spierings, Hajime Fujii, Buxiang Sun, Thomas Walshe, Journal of Nutritional Science and Vitaminology, 53: 536-539 (2007).
Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol. Hajime Fujii, Buxiang Sun, Hiroshi Nishioka, Aya Hirose, Okezie I. Aruoma, Food and Chemical Toxicology, 45: 378-387 (2007).
Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes. Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka, Eri Sato, Aya Hirose, Yasuhiro Ueno, Buxiang Sun, Takako Yokozawa, Gen-ichiro Nonaka, Journal of Agricultural and Food Chemistry, 55(4): 1525-1531 (2007).
Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol. Koji Tomobe, Hajime Fujii, Buxiang Sun, Hiroshi Nishioka, Okezie I. Aruoma, Biomedicine & Pharmacotherapy, 61: 427-434 (2007).
Platelet Reactivity in Male Smokers Following the Acute Consumption of a Flavanol-Rich Grapeseed Extract. John A. Polagruto, Heidrun B. Gross, Faranak Kamangar, Ken-ichi Kosuna, Buxiang Sun, Hajime Fujii, Carl L. Keen, Robert M. Hackman, Journal of Medicinal Food, 10(4): 725-730 (2007).
Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Hernan Aviles, Phyllis O’Donnell, Julia Orshal, Hajime Fujii, Buxiang Sun, Gerald Sonnenfeld, The American Journal of Surgery, 195: 537-545 (2008).
Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. Claire M. Mach, Hajime Fujii, Koji Wakame, Judith Smith, Journal of the Society for Integrative Oncology, 6(3): 105-109 (2008).
Flavanols: digestion, absorption and bioactivity. Robert M. Hackman, Phytochemistry Reviews, 7: 195-208 (2008).
Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin--AP-1 and C/EBP as potential upstream targets. Joydeb Kumar Kundu, Eun-Jin Chang, Hajime Fujii, Buxiang Sun, Young-Joon Surh, Photochemistry and Photobiology, 84: 399-406 (2008).
Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes. Takuya Sakurai, Hiroshi Nishioka, Hajime Fujii, Norihiko Nakano, Takako Kizaki, Zsolt Radak, Tetsuya Izawa, Shukoh Haga, Hideki Ohno, Bioscience, Biotechnology, and Biochemistry, 72(2): 463-476 (2008).
The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes. Hideki Ohno, Takuya Sakurai, Tatsuya Hisajima, Shigeru Abe, Takako Kizaki, Jun-Etsu Ogasawara, Yoshinaga Ishibashi, Kazuhiko Imaizumi, Tohru Takemasa, Shukoh Haga, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Advances in Exercise and Sports Physiology, 13(4): 93-99 (2008).
Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts. Hajime Fujii, Hiroshi Nishioka, Koji Wakame, Bernadene A. Magnuson, Ashley Roberts, Food and Chemical Toxicology, 46(12): 3553-3562 (2008).
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. Shuhui Wang, Thomas Welte, Hao Fang, Gwong-Jen J. Chang, Willi K. Born, Rebecca L. O’Brien, Buxiang Sun, Hajime Fujii, Ken-Ichi Kosuna, Tian Wang, The Journal of Nutrition Nutritional Immunology, 139: 598-602 (2009).
The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents. Buxiang Sun, Koji Wakame, Eri Sato, Hiroshi Nishioka, Okezie I. Aruoma, Hajime Fujii, Cancer Epidemiology, 33: 293-299 (2009).
Alleviating effect of active hexose correlated compound (AHCC) for anticancer drug-induced side effects in non-tumor-bearing mice. Kota Shigama, Akihiro Nakaya, Koji Wakame, Hiroshi Nishioka, Hajime Fujii, Journal of Experimental Therapeutics and Oncology, 8(1): 43-51 (2009).
Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-κB and C/EBP as potential targets. Joydeb Kumar Kundu, Dal-Mi Hwang, Jung-Chul Lee, Eun-Jin Chang, Young Kee Shin, Hajime Fujii, Buxiang Sun, Young-Joon Surh, Cancer Letters, 273: 86-97 (2008).
Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin. Joydeb Kumar Kundu, Ki-Seok Choi, Hajime Fujii, Buxiang Sun, Young-Joon Surh, Journal of Functional Foods, 1(1): 98-108 (2009).
Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway. Junetsu Ogasawara, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Takuya Sakurai, Takako Kizaki, Tetsuya Izawa, Hitoshi Ishida, Hideki Ohno, Phytotherapy Research, 23: 1626-1633 (2009).
Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee. Jun Nishihira, Maremi Sato-Ueshima, Kentaro Kitadate, KojiWakame, Hajime Fujii, Journal of Functional Foods, 1(4): 341-348 (2009).
Review of Cancer Therapy with AHCC(R) and GCP(R); The Long-Term Follow-Up over 12 Years for Stage IV (M1) Cancer of the Lung and the Breast. Reiki Ishizuka, Hajime Fujii, Takehito Miura, Yukiko Fukuchi, Kuniyoshi Tajima, International Journal of Integrative Medicine, 2(1): 98-111 (2010).
Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor–α in healthy adults. Zhinan Yin, Hajime Fujii, Thomas Walshe, Human Immunology, 71: 1187-1190 (2010).
Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages. Takuya Sakurai, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Takako Kizaki, Yasumasa Kondoh, Tetsuya Izawa, Hitoshi Ishida, Zsolt Radák, Hideki Ohno, Journal of Nutritional Biochemistry, 21: 47-54 (2010).
Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Xiao-Hong Zhang, Hiroki Yokoo, Hiroshi Nishioka, Hajime Fujii, Naoyuki Matsuda, Toshio Hayashi, Yuichi Hattori, British Journal of Pharmacology, 159: 928–938 (2010).
Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models. Swati Kalgaonkar, Hiroshi Nishioka, Heidrun B. Gross, Hajime Fujii, Carl L. Keen, Robert M. Hackman, Phytotherapy Research, 24(8): 1223-1228 (2010).
Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice. Jeong Sook Noh, Hyun Young Kim, Chan Hum Park, Hajime Fujii, Takako Yokozawa, British Journal of Nutrition, 104(8): 1120-1128 (2010).
Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes. Junetsu Ogasawara, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Takuya Sakurai, Takako Kizaki, Tetsuya Izawa, Hitoshi Ishida, Masataka Tanno, Hideki Ohno, Biochemical and Biophysical Research Communications, 402: 554-559 (2010).
Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes. Junetsu Ogasawara, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Takuya Sakurai, Takako Kizaki, Tetsuya Izawa, Hitoshi Ishida, Hideki Ohno, Phytotherapy Research, 25(3): 467-471 (2010).
Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC). H. Fujii, N. Nishioka, R.R. Simon, R. Kaur, B. Lynch, A. Roberts, Regulatory Toxicology and Pharmacology, 59(2): 237-250 (2011).
Evaluation of active hexose correlated compound (AHCC) in combination with pegylated liposomal doxorubicin for treatment of ovarian cancer. Hunter RJ, Fujii H, Wakame K, Gaikwad A, Wolf JK, Smith JA, The International Journal of Applied Research, 4(3): 6-14 (2011).
Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1b production from monocytes in humans. Won-Woo Lee, Naeun Lee, Hajime Fujii, Insoo Kang, Cellular Immunology, 275(1-2): 19-23 (2012).
Personalized cancer therapy for stage IV non-small cell lung cancer: Combined use of active hexose correlated compound and genistein concentrated polysaccharide. Reiki Ishizuka, Hajime Fujii, Takehito Miura, Yukiko Fukuchi, Kuniyoshi Tajima, Personalized Medicine Universe, 1(1): 39-44 (2012).
Active Hexose Correlated Compound (AHCC) Alleviates Gemcitabine-Induced Hematological Toxicity in Non-Tumor-Bearing Mice. Daisuke Nakamoto, Kota Shigama, Hiroshi Nishioka, Hajime Fujii, International Journal of Clinical Medicine, 3: 361-367 (2012).
Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats. Mahesh Thirunavukkarasu, Lijun Zhan, Koji Wakame, Hajime Fujii, Hiroyoshi Moriyama, Manashi Bagchi, Toxicology Mechanisms and Methods, 22(7): 555-559 (2012).