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Ahmed Bettaieb

Ahmed Bettaieb

  • Assistant Researcher Step IV

3150E Meyer

(530) 752-2645



  • Ph.D., University of Quebec at Montreal, Canada
  • M.Sc., University of Quebec at Montreal, Canada

Research Interests

Obesity and/or disorders of adipose tissue are classified according to the National Heart, Lung, and Blood Institute (NHLBI) and the American Heart Association (AHA) as the most potential etiologic risk factors for metabolic syndrome and cardiovascular diseases. Indeed, hyperplasia and hypertrophy of adipocytes as seen in obesity leads to increased production of leptin, tumor necrosis factor α, interleukin-6, acylation-stimulating protein and many other proteins, and decreased production of adiponectin, all known to be cardiovascular disease hallmarks. There is also substantial evidence that weight loss, particularly the mobilization of visceral adipose tissue, leads to simultaneous improvements of the metabolic profile. Dr. Bettaieb’s research projects focus on the role of protein tyrosine phosphatases in the metabolic functions of adipose tissue and aim to improve our understanding of the molecular signaling mechanisms as this will aid in the development of more effective therapies for obesity and its associated disorders.

Selected Publications

  • Ahmed Bettaieb, Jesse Bakke, Naoto Nagata, Kosuke Matsuo, Yannan Xi, Daniel Aboubechara, Ramzi Melhem, Stanhope Kimber, Bethany Cummings, James Graham, Bremer Andrew, Sheng Zhang, Zhang, Costas Lyssiotis, Zhong-Yin, Lewis Cantley, Peter Havel and Fawaz Haj. Protein-Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation. J Biol Chem. 2013 May 2. [Epub ahead of print] PMID: 23640882.
  • Ahmed Bettaieb, Naoto Nagata, Daniel Aboubechara, Samah Chahed, Morisseau Christophe, Bruce Hammock and Fawaz Haj. 2013. Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-Induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue. 2013 May 17;288(20):14189-99. PMID: 23576437.
  • Denise Lackey, Christopher Lynch, Kristine Olson, Rouzbeh Mostaedi, Mohamed Ali, William Smith, Fredrik Karpe, Sandy Humphreys,Daniel Bedinger, Tamara Dunn, Anthony Thomas, Pieter Oort, Dorothy Kieffer, Rajesh Amin, Ahmed Bettaieb, Fawaz Haj, Paska Permana, Tracy Anthony and Sean Adams. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab. 2013 Jun;304(11):E1175-87. PMID: 23512805.
  • Ahmed Bettaieb, Paulina Wrzal and Diana Averill-Bates. Book title: Current Cancer Treatment - Novel Beyond Conventional Approaches Chapter title: Hyperthermia: Cancer Treatment and Beyond (E. Book chapter).
  • Bethany Cummings,  Ahmed Bettaieb, James L. Graham, Jaehyoung Kim, Fangrui Ma, Noreene Shibata, Kimber L. Stanhope,  Cecilia Guilivi, Frederik Hansen, Jacob Jelsing, Niels Vrang, Mark Kowala, Michael L. Chouinard, Fawaz G. Haj, and Peter J. Havel. 2012. Ileal Interposition Surgery Increases Plasma Bile Acids, Decreases Endoplasmic Reticulum Stress, and Increases β-cell Mass in the UCD-T2DM Rat. Dis Model Mech.
  • Bora Inceoglu, Karen Wagner, Jun Yang, , Ahmed Bettaieb, Nils H. Schebb, Fawaz Haj and Bruce Hammock. 2012. Augmentation of epoxygenated fatty acid levels rapidly reduce pain-related behavior without significantly altering acute glucose metabolism in a rat model of type I diabetes. Proc Natl Acad Sci USA.
  • Bethany Cummings, Ahmed Bettaieb, James Graham, Kimber Stanhope, Mark Kowala, Fawaz Haj, Michael Chouinard, and Peter Havel. 2012. Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Accepted for publication in Endocrinology.
  • Naoto Nagata, Kosuke Matsuo , Ahmed Bettaieb , Jesse Bakke , James Graham, Izumi Matsuo , Siming Liu, Yannan Xi , Susan Gray, Dae Young Jung, Jason Kim, Peter Havel and Fawaz Haj . 2012. Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice. Accepted for publication in Endocrinology. 153(7):3158-69.
  • Ahmed Bettaieb , Kosuke Matsuo , Izumi Matsuo , Shuo Wang , Ramzi Melhem , Antonis Koromilas  and Fawaz Haj. 2012. Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2alpha Signaling in Brown Adipocytes. Plos One; 7(4):e34412.
  • Vazquez Prieto Marcela, Ahmed Bettaieb, Fawaz Haj, Fraga César and Oteiza Patricia. 2012. (-)-Epicatechin prevents TNFα-induced activation of signaling cascades leading to inflammation and insulin resistance in 3T3 adipocytes. Archives of Biochemistry and Biophysics.
  • Bethany Cummings, Ahmed Bettaieb, James Graham, Kimber Stanhope, Riva Dill, Gregory Morton, Fawaz Haj and Peter Havel. 2011. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci USA.
  • Ayala Luria, Ahmed Bettaieb , Yannan Xi, Guang-Jong Shieh, Hsin-Chen Liu, Hiromi Inoue, Hsing-Ju Tsai , John Imig, Fawaz Haj  and Bruce Hammock .  2011. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance induced by high fat diet.  Proc Natl Acad Sci U S A. 31; 108(22):9038-43.
  • Ahmed Bettaieb , Kosuke Matsuo, Izumi Matsuo  and Fawaz Haj. 2011.  Adipose-specific Src Homology Phosphatase 2 deficiency does not significantly alter systemic glucose homeostasis.  Metabolism. 60; (8): 1193-01.
  • Ahmed Bettaieb , Siming Liu, Yannan Xi, Naoto Nagata, Kosuke Matsuo , Izumi Matsuo , Samah Chahed, Jesse Bakke, Heike Keilhack , Tony Tiganis and Fawaz Haj.  2011. Differential regulation of endoplasmic reticulum stress by protein tyrosine phsophatase 1B and T cell protein tyrosine phosphatase.  J Biol Chem. 18; 286(11):9225-35.
  • Kosuke Matsuo, Ahmed Bettaieb, Naoto Nagata , Izumi Matsuo  and Fawaz Haj. 2011. Role of protein tyrosine phosphatase 1B in brown adipocyte differentiation.  PLoS One. 31; 6(1):e16446-57.
  • Kosuke Matsuo , Mirela Delibegovic , Izumi Matsuo , Naoto Nagata, Siming Liu, Ahmed Bettaieb , Yannan Xi , Kazu Araki, Wentien Yang , Barbara Kahn, Benjamin Neel  and Fawaz Haj. 2010.  Altered glucose homeostasis in mice with liver-specific deletion of Src Homology Phosphatase 2.  J Biol Chem. 17; 285(51):39750-8.
  • Julie Roy , Pragathie Pallepati , Ahmed Bettaieb  and Diana Averill-Bates . 2010. Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. Can J Physiol Pharmacol. 88(3):353-68.
  • Julie Roy, Pragathie Pallepati, Ahmed Bettaieb  and Diana Averill-Bates. 2009. Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chem Biol Interact. 7; 181(2):154-67.
  • Ahmed Bettaieb and Diana Averill-Bates. 2008. Thermotolerance induced at a fever temperature of 40 degrees C protects cells against hyperthermia-induced apoptosis mediated by death receptor signalling. Biochem Cell Biol. 86(6):521-38.
  • Paulina Wrzal , Ahmed Bettaieb , Diana Averill-Bates. 2008. Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiat Res. 170(4):498-511.
  • Ahmed Bettaieb  and Diana Averill-Bates. 2005. Thermotolerance induced at a mild temperature of 40 degrees C protects cells against heat shock-induced apoptosis. J Cell Physiol. 205(1):47-57.