UC Davis Nutrition Department Faculty

Photo
Charles H. Halsted
Professor Emeritus of Internal Medicine and Nutrition.
Office: 6323 Genome and Biomedical Sciences Facility
Phone: (530) 752-6778  Fax: (530) 752-3470
e-mail: chhalsted@ucdavis.edu

Education
1958 B.A., History, Stanford University
1962 M.D., University of Rochester School of Medicine
1962-63 Internship in Medicine, Cleveland Metropolitan General Hospital
1963-65 Assistant Resident in Medicine, Cleveland Metropolitan General Hospital
1965-66 Chief Resident in Medicine, Cleveland Metropolitan General Hospital
1968-70 Fellow in Gastroenterology, The Johns Hopkins Hospital, Baltimore
Certification
American Board of Internal Medicine, 3/20/70 (recertification 10/29/77)
American Board of Internal Medicine, Subspecialty of Gastroenterology, 10/16/73
American Board of Nutrition, Specialist in Human and Clinical Nutrition, 5/2/84

Research Interests
Dr. Halsted's research activities focus on the regulation of folate absorption and metabolism in health and various diseases. His group characterized the properties of folate hydrolase, an intestinal enzyme that regulates folate absorption. These studies included the molecular sequence of its gene glutamate carboxypeptidase (GCPII) and identification of a unique polymorphism in GCPII associated with decreased enzyme activity. Ongoing work focuses on GCPII genotype screening of human populations who are at risk for folate deficiency with attendant hyperhomocysteinemia and its associated clinical conditions that include increased risks for cardiovascular diseases, neural tube defects, and decreased cognition in aging. A second active research program evaluates the roles of folate deficiency and hyperhomocysteinemia in the pathogenesis of alcoholic liver disease. Using a micropig model, his group demonstrated that the development of alcoholic liver disease was promoted by the combination of folate deficiency with hyperhomocysteinemia and alcohol feeding. Ongoing studies focus on disease mechanisms including effects of alcohol exposure on enzymes that regulate homocysteine metabolism and the potential effects of increased homocysteine and its related metabolites on signal pathways for liver injury.

Selected Publications

1.  Halsted CH, Griggs RC, Harris JW. The effect of alcoholism on the absorption of folic acid (3H-PGA) evaluated by plasma levels and urine excretion. J Lab Clin Med 1967; 69:116-31.

2. Hines JD, Halsted CH, Griggs RC, Harris JW. Megaloblastic anemia secondary to folate deficiency associated with hypothyroidism. Ann Intern Med 1968; 68:792-809.

3. Halsted CH, Sheir S, Sourial N, Patwardhan VN. Small intestinal structure and absorption in Egypt: influence of parasitism and pellagra. Am J Clin Nutr 1969; 22:744-54.

4. Halsted CH, Sourial N, Guindi S, Mourad K, Kattab A, Patwardhan VN, Carter JP. Anemia of kwashiorkor in Cairo: deficiencies of protein, iron and folic acid. Am J Clin Nutr 1969; 22:1371-82.

5. Halsted CH, Sheir S, Raasch FO. The small intestine in human schistosomiasis [letter]. Gastroenterology 1969; 57:622-23.

6. McCaffrey RP, Halsted CH, Wahab MFA, Robertson RP. Chloramphenicol induced hemolysis in Caucasian glucose-6-phosphate dehydrogenase deficiency. Ann Intern Med 1971; 74:722-26.

7. Halsted CH, Grayer DE, Luebbers EH, Yardley JH, Hendrix TR. Effect of cycloheximide on intestinal secretion induced by hypertonic glucose. Gut 1971; 12:262-67.

8. Halsted CH, Bright LS, Luebbers EH, Bayless TM, Hendrix TR. A comparison of jejunal response to cholera exotoxin and hypertonic mannitol. Johns Hopkins Med J 1971; 129:179-89.

9. Halsted CH, Robles EA, Mezey E. Decreased jejunal uptake of labeled folic acid (3H-PGA) in alcoholic patients: roles of alcohol and malnutrition. N Engl J Med 1971; 285:701-6.

10. Yardley JH, Bayless TM, Luebbers EH, Halsted CH, Hendrix TR. Goblet cell mucus in the small intestine. Findings after net fluid production due to cholera toxin and hypertonic solutions. Johns Hopkins Med J 1972; 131:1-10.

11. Halsted CH, McIntyre P. Intestinal malabsorption caused by aminosalicylic acid therapy. Arch Intern Med 1972; 130:935-39.

12. Halsted CH, Robles EA, Mezey E. Intoxicated enterocytes? [letter]. N Engl J Med 1972; 286:160.

13. Halsted CH, Robles EA, Mezey E. Intestinal malabsorption in folate-deficient alcoholics. Gastroenterology 1973; 64:526-32.

14. Halsted CH, Robles E, Mezey E. Distribution of ethanol in the human gastrointestinal tract. Am J Clin Nutr 1973; 26:831-34.

15. Halsted CH. Small intestine in pellagra [letter]. Am J Clin Nutr 1973; 26:1.

16. Robles EA, Mezey E, Halsted CH, Schuster MM. Effect of ethanol on motility of the small intestine. Johns Hopkins Med J 1974; 135:17-24.

17. Bhanthumnavin K, Wright JR, Halsted CH. Intestinal transport of tritiated folic acid (3H-PGA) in the everted gut sac of different aged rats. Johns Hopkins Med J 1974; 135:152-60.

18. Halsted CH, Bhanthumnavin K, Mezey E. Jejunal uptake of tritiated folic acid in the rat studied by in vivo perfusion. J Nutr 1974; 104:1674-80.

19. Halsted CH. On the pathogenesis of gluten sensitive enteropathy [review]. Nutr Rev 1974; 32:267-70.

20. Halsted CH. Current status of jejuno-ileal bypass for obesity [review]. Nutr Rev 1974; 32:333-36.

21. Halsted CH, Baugh CM, Butterworth CE. Jejunal perfusion of simple and conjugated folates in man. Gastroenterology 1975; 68:261-69.

22. Halsted CH, Rowe J. Occurrence of celiac sprue in a patient with Fabry's disease. Ann Intern Med 1975; 83:324-25.

23. Halsted CH. The small intestine in vitamin B12 and folate deficiency [review]. Nutr Rev 1975; 33:33-37.

24. Halsted CH. Recent clinical correlates of vitamin D metabolites and calcium metabolism [review]. Nutr Rev 1975; 33:209-10.

25. Halsted CH, Reisenauer AM, Back C, Gotterer GS. In vitro uptake and metabolism of pteroylpolyglutamate by rat small intestine. J Nutr 1976; 106:485-92.

26. Yassinger S, Adelman R, Cantor D, Halsted CH, Bolt R. Association of inflammatory bowel disease and large vascular lesions. Gastroenterology 1976; 71:844-46.

27. Corcino JJ, Reisenauer AM, Halsted CH. Jejunal perfusion of simple and conjugated folates in tropical sprue. J Clin Invest 1976; 58:298-305.

28. Halsted JA, Halsted CH. Getting nutrition into the medical school [editorial]. Ann Intern Med 1976; 84:334-5.

29. Halsted CH. Folic acid, ethanol, and jejunal glycolysis [review]. Nutr Rev 1976; 34:73-5.

30. Halsted CH. Water and sodium transport in alcoholism [letter]. Gastroenterology 1977; 73:1187.

31. Adelman RD, Abern SB, Merten D, Halsted CH. Hypercalcinuria with nephrolithiasis: a complication of total parenteral nutrition. Pediatrics 1977; 59:473-5.

32. Halsted CH, Reisenauer AM, Romero JJ, Cantor DS, Ruebner B. Jejunal perfusion of simple and conjugated folates in celiac sprue. J Clin Invest 1977; 59:933-40.

33. Reisenauer AM, Krumdieck CL, Halsted CH. Folate conjugase: two separate activities in human jejunum. Science 1977; 198:196-7.

34. Halsted CH. Intestinal adaptation and hepatic decompensation after jejunoileal bypass for morbid obesity [review]. Nutr Rev 1977; 35:43-5.

35. Halsted CH, Reisenauer AM, Shane B, Tamura T. Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with celiac sprue. Gut 1978; 19:886-91.

36. Halsted CH. The intestinal absorption of folates. Am J Clin Nutr 1979; 32:846-55.

37. Mezey E, Potter JJ, Slusser RJ, Brandes D, Romero J, Tamura T, Halsted CH. Effect of ethanol feeding on hepatic lysosomes in the monkey. Lab Invest 1980; 43:88-93.

38. Halsted CH. Intestinal absorption and malabsorption of folates [review]. Ann Rev Med 1980; 31:79-87.

39. Halsted CH. Alcoholism and malnutrition. Introduction to the symposium [review]. Am J Clin Nutr 1980; 33:2705-8.

40. Halsted CH, Stern JS. ASCN workshop on obesity and its treatments, Sacramento, CA, October 5, 1979 [review]. Am J Clin Nutr 1980; 33:1326-27.

41. Halsted CH. Folate deficiency in alcoholism [review]. Am J Clin Nutr 1980; 33:2736-40.

42. Romero JJ, Tamura T, Halsted CH. Intestinal absorption of [3H]folic acid in the chronic alcoholic monkey. Gastroenterology 1981; 80:99-102.

43. Tamura T, Romero JJ, Watson JE, Gong EJ, Halsted CH. Hepatic folate metabolism in the chronic alcoholic monkey. J Lab Clin Med 1981; 97:654-61.

44. Reisenauer AM, Halsted CH. Human brush border folate conjugase: characteristics and inhibition by salicylazosulfapyridine. Biochim Biophys Acta 1981; 659:62-69.

45. Halsted CH, Gandhi G, Tamura T. Sulfasalazine inhibits the absorption of folates in ulcerative colitis. N Engl J Med 1981; 305:1513-17.

46. Halsted CH. Effects of ethanol on the stomach and small intestine [review], pp. 206-208. In: Geokas MC, moderator. Ethanol, liver, and the gastrointestinal tract. Ann Intern Med 1981; 95:198-211.

47. Halsted CH, Tamura T. Folate levels in inflammatory bowel disease [letter]. N Engl J Med 1982; 306:1488.

48. Halsted CH. Nutrition and diet therapy in gastrointestinal diseases (by MH Floch) [book rev]. Gastroenterology 1982; 83:504.

49. Rosenberg IH, Bowman BB, Cooper BA, Halsted CH, Lindenbaum J. Folate nutrition in the elderly [review]. Am J Clin Nutr 1982; 36:1060-66.

50. French SW, Ruebner BH, Mezey E, Tamura T, Halsted CH. Effect of chronic ethanol feeding on hepatic mitochondria in the monkey. Hepatology 1983; 3:34-40.

51. Mezey E, Potter JJ, French SW, Tamura T, Halsted CH. Effect of chronic ethanol feeding on hepatic collagen in the monkey. Hepatology 1983; 3:41-44.

52. Tamura T, Halsted CH. Folate turnover in chronically alcoholic monkeys. J Lab Clin Med 1983; 101:623-8.

53. Wolfe BM, Beer WH, Hayashi JT, Halsted CH, Cannon RA, Cox KL. Experience with home parenteral nutrition. Am J Surg 1983; 146:7-14.

54. Burbige EJ, Lewis DR, Halsted CH. Alcohol and the gastrointestinal tract [review]. Med Clin North Am 1984; 68:77-89.

55. Bailey LB, Cerda JJ, Block BS, Busby MJ, Vargas L, Chandler CJ, Halsted CH. Effects of age on poly- and monoglutamyl folacin absorption in human subjects. J Nutr 1984; 114:1770-76.

56. Halsted CH. Folate turnover in alcoholism [letter]. Am J Clin Nutr 1984; 39:343-44.

57. Halsted CH. Testimony at a hearing before the Select Committee on Hunger. US House of Representatives, Davis, CA, July 21, 1984. Washington, DC: US Government Printing Office, Serial No. 98-3, 1984: 36-39, 155-59.

58. Beer WH, Fan A, Halsted CH. Clinical and nutritional implications of radiation enteritis. Am J Clin Nutr 1985; 41:85-91.

59. Keen CL, Tamura T, Lonnerdal B, Hurley LS, Halsted CH. Changes in hepatic superoxide dismutase activity in alcoholic monkeys. Am J Clin Nutr 1985; 41:929-32.

60. Wang TTY, Reisenauer AM, Halsted CH. Comparison of folate conjugase activities in human, pig, rat and monkey intestine. J Nutr 1985; 115:814-19.

61. Reisenauer AM, Halsted CH, Jacobs LR, Wolfe BM. Human intestinal folate conjugase: adaptation after jejunoileal bypass. Am J Clin Nutr 1985; 42:660-65.

62. Halsted CH. Absorption and malabsorption of mineral nutrients (by NW Solomons, IH Rosenberg) [book rev]. Gastroenterology 1985; 89:1208.

63. Halsted CH. Nutrition in gerontology (by JM Ordy, D Harman, RB Alfin-Slater) [book rev]. Geriatric Med Today 1985; 5:113-15.

64. Burr RE, Gallagher C, Halsted CH, Hubbard V, Shike M, Murphy JP. Nutrition and primary care [review]. Patient Care 1986; Jun:18-163.

65. Wolfe BM, Ryder MA, Nishikawa RA, Halsted CH, Schmidt BF. Complications of parenteral nutrition. Am J Surg 1986; 152:93-99.

66. Halsted CH, Beer WH, Chandler CJ, Ross K, Wolfe BM, Bailey L, Cerda JJ. Clinical studies of intestinal folate conjugases. J Lab Clin Med 1986; 107:228-32.

67. Chandler CJ, Wang TTY, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders: purification and characterization. J Biol Chem 1986; 261:928-33.

68. Reisenauer AM, Chandler CJ, Halsted CH. Folate binding and hydrolysis by pig intestinal brush border membranes. Am J Physiol 1986; 251:G481-86.

69. Wang TTY, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa: isolation and characterization. J Biol Chem 1986; 261:13551-55.

70. Reisenauer AM, Halsted CH. Issues and opinions in nutrition: human folate requirements [review]. J Nutr 1987; 117:600-2.

71. Tamura T, Kaiser LL, Watson JE, Halsted CH, Hurley LS, Stokstad ELR. Increased methionine synthetase activity in zinc-deficient rat liver. Arch Biochem Biophys 1987; 256:311-16.

72. Halsted CH, Heise C. Ethanol and vitamin metabolism [review]. Pharmacol Ther 1987; 34:453-64.

73. Reisenauer AM, Halsted CH. Reply to the Letter of Dr. Baggott (extrapolating in vitro to in vivo nutrient requirements) [letter]. J Nutr 1987; 117:2163.

74. Soberon S, Pauley MP, Duplantier R, Fan A, Halsted CH. Metabolic effects of enteral formula feeding in alcoholic hepatitis. Hepatology 1987; 7:1204-9.

75. Halsted CH. The American Society for Clinical Nutrition as an academic society. Am J Clin Nutr 1989; 50:215-20.

76. Reisenauer AM, Buffington CAT, Villanueva JA, Halsted CH. Folate absorption in alcoholic pigs: in vivo intestinal perfusion studies. Am J Clin Nutr 1989; 50:1429-35.

77. Naughton CA, Chandler CJ, Duplantier RB, Halsted CH. Folate absorption in alcoholic pigs: in vitro hydrolysis and transport at the intestinal brush border membrane. Am J Clin Nutr 1989; 50:1436-41.

78. Halsted CH. Intestinal absorption and malabsorption of dietary folates [review]. J Am Coll Nutr 1989; 8:650-58.

79. Zidenberg-Cherr S, Halsted CH, Olin KL, Reisenauer AM, Keen CL. The effect of chronic alcohol ingestion on free-radical defense in the miniature pig. J Nutr 1990; 120:213-17.

80. Halsted CH. Periconceptional use of multivitamins and the prevalence of neural tube defects [letter]. N Engl J Med 1990; 322:1082.

81. Halsted CH, Keen CL. Alcoholism and micronutrient metabolism and deficiencies [review]. Eur J Gastroenterol Hepatol 1990; 2:399-405.

82. Heise C, Dandekar S, Kumar P, Duplantier R, Donovan RM, Halsted CH. Human immunodeficiency virus infection of enterocytes and mononuclear cells in human jejunal mucosa. Gastroenterology 1991; 100:1521-27.

83. Zidenberg-Cherr S, Olin KL, Villanueva J, Tang A, Phinney SD, Halsted CH, Keen CL. Ethanol-induced changes in hepatic free-radical defense mechanisms and fatty acid composition in the miniature pig. Hepatology 1991; 13:1185-92.

84. Chandler CJ, Harrison DA, Buffington CA, Santiago NA, Halsted CH. Functional specificity of jejunal brush-border pteroylpolyglutamate hydrolase in pig. Am J Physiol 1991; 260:G865-72.

85. Monsen ER, Vanderpool HY, Halsted CH, McNutt KW, Sandstead HH. Ethics: responsible scientific conduct. Am J Clin Nutr 1991; 54:1-6.

86. Halsted CH. Jejunal brush-border folate hydrolase a novel enzyme [review]. West J Med 1991; 155:605-9.

87. Consensus Development Conference Panel. Gastrointestinal surgery for severe obesity: Consensus Development Conference statement. Ann Intern Med 1991; 115:956-61.

88. Halsted CH. Toward standardized training of physicians in clinical nutrition. Am J Clin Nutr 1992; 56:1-3.

89. Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. Reduced tissue arachidonic acid concentration with chronic ethanol feeding in miniature pigs. Am J Clin Nutr 1992; 56:467-74.

90. Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. The body composition and lipid metabolic effects of chronic ethanol during a high omega-6 polyunsaturated fatty acid diet in micropigs. Metabolism 1993; 42:1340-50.

91. Heise C, Vogel P, Miller CJ, Halsted CH, Dandekar S. Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques: functional, pathological, and morphological changes. Am J Pathol 1993; 142:1759-71.

92. Halsted CH, Villanueva J, Chandler CJ, Ruebner B, Munn RJ, Parkkila S, Niemelä O. Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 1993; 18:954-60.

93. Halsted CH. Medical and nutritional complications of alcoholism: mechanisms and management (by CS Lieber, ed) [book rev]. Am J Clin Nutr 1994; 59:1096.

94. Halsted CH. Folate requirements and metabolism in alcoholic liver disease [review]. Nutr Res 1994; 14:1439-56.

95. Villanueva J, Chandler CJ, Shimasaki N, Tang A, Nakamura M, Phinney SD, Halsted CH. Effects of ethanol feeding on liver, kidney, and jejunal membranes in micropigs. Hepatology 1994; 19:1229-40.

96. Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. Selective reduction of D6 and D5 desaturase activities but not D9 desaturase in micropigs chronically fed alcohol. J Clin Invest 1994; 93:450-54.

97. Niemelä O, Parkkila S, Ylä-Herttuala S, Halsted C, Witztum J, Lanca A, Israel Y. Covalent chemical addition products in the liver and erythrocytes of alcohol consumers. Lab Invest 1994; 70:537-46.

98. Stone JD, Heise CC, Miller CJ, Halsted CH, Dandekar S. Development of malabsorption and nutritional complications in simian immunodeficiency virus-infected rhesus macaques. AIDS 1994; 8:1245-56.

99. Halsted CH. The importance of malnutrition in a patient with malabsorption. Gastroint Dis Today 1994; 3(6):1-9.

100. Halsted CH. Organ metabolism and nutrition: ideas for future critical care by JM Kinney, HN Tucker, eds [book rev]. Am J Clin Nutr 1995; 61:1.

101. Halsted CH. Certification of clinical nutritionists [commentary]. Am J Clin Nutr 1995; 62:10-12.

102. Niemelä O, Parkkila S, Ylä-Herttuala S, Villanueva J, Ruebner B, Halsted C. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 1995; 22:1208-14.

103. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology 1996; 23:497-505.

104. Halsted CH, Newton J, Phinney SD. Obesity and its health risks. Curr Opin Gastroenterol 1996; 12:204-9.

105. Halsted CH. The many faces of celiac disease [editorial]. N Engl J Med 1996; 334:1190-91.

106. Van Hoozen CM, Ling E, Halsted CH. Folate binding protein: molecular characterization and transcript distribution in pig liver, kidney, and jejunum. Biochem J 1996; 319:725-29.

107. Van Hoozen CM, Peeke PG, Taubeneck M, Frey CF, Halsted CH. Efficacy of enzyme supplementation after surgery for chronic pancreatitis. Pancreas 1997; 14:174-80.

108. Halsted CH. A new beginning [editorial]. Am J Clin Nutr 1997; 66:1.

109. Halsted CH. Nutrition epidemiology in The American Journal of Clinical Nutrition [editorial]. Am J Clin Nutr 1998; 67:83.

110. Halsted CH. Clinical nutrition education -relevance and role models. Am J Clin Nutr 1998; 67:192-96.

111. Halsted CH, Ling E-H, Luthi-Carter R, Villanueva JA,Gardner JM, Coyle JT. Folylpoly-g-glutamate carboxypeptidase from pig jejunum: molecular characterization and elation to glutamate carboxypeptidase II. J. Biol Chem 1998; 273:20417-20424.

112. Villanueva JA, Ling, E-H, Chandler CJ, Halsted CH. Membrane and tissue distribution offolate binding protein in pig. Am J Physiol 1998; 275P R1503-R1510.

113. Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, Heimburger DC, Lucas CP, Robbins DC, Chung J, Heymsfield SB. Weight control and risk factor reduction in obese subjects treated for two years with orlistat. JAMA 1999; 281235-42.

114. Halsted CH. Obesity effects on the liver and gastrointestinal system. Curr Opin in Clinical Nutrition and Metabolic Care 1999; 2 425-429.

115. Halsted CH. The relevance of clinical nutrition education and role models to the practice of medicine. Eur J Clin Nutr 1999; 53 S29-S34

116. Niemela O, Parkkila S, Pasanen M, Vitala K, Villanueva JA, Halsted CH Induction of Cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcoholic liver disease in micropigs. Hepatology 1999;301011-1017.

117. Parkkila S, Halsted CH, Villanueva JA, Väänänen, HK, Niemelä O. Expression of testosterone-dependent enzyme, carbonic anhydrase III and oxidative stress in experimental alcoholic liver disease. Dig Dis Sci 1999 442205-13.

118. Halsted CH. Dietary supplements and the American Journal of Clinical Nutrition [editorial]. Am J Clin Nutr 2000;71399-400.

119. Said HM, Chatterjee N, ul Haq R, Subramanian VS, Ortiz A, Matherly LH, Sirotnak FM, Halsted CH, Rubin SA. Adaptive regulation of intestinal folate uptake effect of dietary folate deficiency. Amer J Physiol 2000;279C1889-C1895

120. Devlin AM, Ling EH, Peerson JM, Clarke R, Smith AD, Halsted CH. Glutamate carboxypeptidase II A polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Human Molecular Genetics 2000;92837-2844

121. Halsted CH. Nutrition in chronic liver disease. Practical Gastroenterology. 2000;2412-23.

122. Halsted CH. Lifestyle effects on homocysteine and an alcohol paradox [editorial]. Am J Clin Nutr 2001;73501-502.

123. Villanueva JA, Devlin AM, Halsted CH. Reduced folate carrier tissue distribution and effects of chronic ethanol intake in the micropig. Alcoholism Clinical and Experimental Research 2001; 25 415-420.

124. Halsted CH, Villanueva JA, Devlin AM, James SJ. Interactions of Ethanol and Folate Deficiency in the Development of Alcoholic Liver Disease in the Micropig. Transactions of the American Clinical and Climatological Association. 2002; 113: 151-163.

125. Halsted CH, Villanueva JA, Devlin AM and Chandler CJ. Metabolic Interactions of Alcohol and Folate. Journal of Nutrition. 2002;132: 2367-2372S.

126. Halsted CH, Villanueva JA and Devlin AM. Folate Deficiency, Methionine Metabolism, and Alcoholic Liver Disease. Alcohol. 2002; 27: 169-172

127. Halsted CH, Villanueva JA, Devlin AM, Parkkila S, Niemelä O, Garrow TA, Wallock LM, Shigenaga M, Melnyk S, James SJ. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proceedings of the National Academy of Science 2002;99:10072-10077.

128. Halsted CH. Dietary supplements and functional foods: 2 sides of a coin? Am J Clin Nutr 2003 77: 1001S-1007S.

129. Morin I, Devlin AM, Leclerc D, Sabbaghian N, Halsted CH, Finnell, R, Rozen R. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.Mol Genet Metab. 2003 Jul;79(3):197-200.

  BOOK CHAPTERS

1. Halsted CH. The infectious diseases: amebiasis. In: Conn H, ed. Current Therapy. Philadelphia: WB Saunders, 1972:2-4.

2. Halsted CH. Gastrointestinal bleeding. In: Halsted JA, ed. The Laboratory in Clinical Medicine. Philadelphia: WB Saunders, 1976:370-3.

3. Halsted CH. Diseases of malabsorption. In: Halsted JA, ed. The Laboratory in Clinical Medicine. Philadelphia: WB Saunders, 1976:374-84.

4. Halsted CH. Diarrhea. In: Halsted JA, ed. The Laboratory in Clinical Medicine. Philadelphia: WB Saunders, 1976:385-93.

5. Halsted CH. Pancreatic and biliary tract disease. In: Halsted JA, ed. The Laboratory in Clinical Medicine. Philadelphia: WB Saunders, 1976:394-99.

6. Halsted CH. Nutritional implications of alcohol. In: Hegsted DM, ed. Present Knowledge of Nutrition. New York: The Nutrition Foundation, 1976:467-77.

7. Halsted CH, Reisenauer AM. Mechanism of absorption, transport and delivery of hematopoietic vitamins: folate hydrolysis and absorption by the small intestine. In: Seno S, Takaku F, Irino S, eds. Topics in Hematology. Amsterdam: Exerpta Medica, 1977:718-19.

8. Halsted CH. Anemia in alcoholism. In: Seno S, Takaku F, Irino S, eds. Topics in Hematology. Amsterdam: Exerpta Medica, 1977:980-81.

9. Halsted CH, Reisenauer AM, Gotterer GS. Process of digestion and absorption of pteroylpolyglutamate. In: Broquist HP, Butterworth CE Jr, Wagner C, eds. Folic Acid: Biochemistry and Physiology in Relation to Human Nutritional Requirement. Washington, DC: National Academy of Sciences, 1977:198-208.

10. Halsted CH. Drugs and water soluble vitamin absorption. In: Hathcock J, Coons J, eds. Nutrition and Drug Interrelations. New York: Academic Press, 1978:83-112.

11. Halsted CH, Tamura T. Folate deficiency in liver disease. In: Davidson CS, ed. Problems in Liver Disease. New York: Stratton Intercontinental Medical Book Co., 1978:91-100.

12. Halsted CH. Folate deficiency and the small intestine. In: Botez ME, ed. Folic Acid in Neurology, Psychiatry, and Internal Medicine. New York: Raven Press, 1979:113-122.

13. Halsted CH, Ott J, Reisenauer AM, Romero JJ. Effect of ethanol on folate absorption. In: Li T-K, Schenker S, Lumeng L, eds. Alcohol and Nutrition. Washington, DC: US Department of Health, Education and Welfare, 1979:207-20.

14. Mezey E, Halsted CH. Effects of alcohol on gastrointestinal and pancreatic function in alcoholics. In: Gastineau C, ed. Fermented Food Beverages in Nutrition. New York: Academic Press, 1981:277-302.

15. Halsted CH, Jacobs LR. Gastrointestinal bleeding and neoplasia. In: Halsted CH, Halsted JA, eds. The Laboratory in Clinical Medicine. 2nd ed. Philadelphia: WB Saunders, 1981:203-11.

16. Halsted CH. Diarrhea syndromes. In: Halsted CH, Halsted JA, eds. The Laboratory in Clinical Medicine. 2nd ed. Philadelphia: WB Saunders, 1981:212-24.

17. Halsted CH. Intestinal malabsorption. In: Halsted CH, Halsted JA, eds. The Laboratory in Clinical Medicine. 2nd ed. Philadelphia: WB Saunders, 1981:225-37.

18. Halsted CH. Disorders of the pancreas. In: Halsted CH, Halsted JA, eds. The Laboratory in Clinical Medicine. 2nd ed. Philadelphia: WB Saunders, 1981:238-44.

19. Halsted CH. Nutrition. In: Bolt RJ, Ruebner BH, Palmer PE, Watson DW, eds. The Digestive System. New York: John Wiley & Sons, 1983:329-44.

20. Chandler CJ, Wang TTY, Halsted CH. Brush border pteroylpolyglutamate hydrolase in pig jejunum. In: Cooper BA, Whitehead VM, eds. Chemistry and Biology of Pteridines. New York: Walter de Gruyter & Co., 1986:539-42.

21. Halsted CH. Alcoholism and folate homeostasis. In: Halsted CH, Rucker RB, eds. Nutrition and the Origins of Disease. San Diego: Academic Press, 1989:249-66.

22. Halsted CH. Folate deficiency in chronic alcoholic liver disease. In: Kim WY, Lee YC, Lee Y, Soon JJ, Kim SH, eds. Proceedings of the 14th International Congress of Nutrition, vol I. Seoul: 1989:465-8.

23. Halsted CH. Intestinal absorption of dietary folates. In: Picciano MF, Stokstad ELR, Gregory JF III, eds. Folic Acid Metabolism in Health and Disease. New York: Wiley-Liss, 1990:23-45.

24. Halsted CH. Chronic alcoholism, malnutrition, and folate deficiency. In: Palmer TN, ed. Alcoholism: a Molecular Perspective. Proceedings of a NATO Advanced Study Institute on the Molecular Pathology of Alcoholism, August 26-September 6, 1990, Il Ciocco, Italy. New York: Plenum Press, 1991:237-52.

25. Halsted CH. Folate metabolism in alcoholism. In: Watson RR, Watzl B, eds. Nutrition and Alcohol. Boca Raton, FL: CRC Press, Inc., 1992:255-67.

26. Halsted CH. The UCD micropig model of alcoholic liver disease. In: Bisson L, ed. Proceedings of a Symposium on Plant Foods in Nutrition. Davis, CA: University of California, Davis, 1992:64-71.

27. Halsted CH. Water-soluble vitamins. In: Garrow J, James WPT, eds. Human Nutrition and Dietetics. 9th ed. Edinburgh, UK: Churchill Livingstone, 1993:239-63.

28. Halsted CH, Van Hoozen CM, Ahmed B. Preoperative nutritional assessment. In: Quigley EMM, Sorrell MF, eds. The Gastrointestinal Surgical Patient: Preoperative and Postoperative Care. Baltimore: Williams & Wilkins, 1994:27-49.

29. Halsted CH. Alcohol and folate interactions: clinical implications. In: Bailey LB, ed. Folate in Health and Disease. New York: Marcel Dekker, 1995:313-28.

30. Halsted CH. Alcohol: medical and nutritional effects. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition, 7th ed. Washington, DC: ILSI Press, 1996:547-56.

31. Phinney SD, Halsted CH. Obesity, anorexia nervosa, and bulimia. In: Feldman M, Scharschmidt BF, Sleisenger MH. Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management, 6th ed. Philadelphia: WB Saunders Co., 1998: 278-297.

32. Halsted CH. Folylpoly-g-glutamate carboxypeptidase. In: Barrett A, Woessner F. Handbook of Proteolytic Enzymes. San Diego: Academic Press, 1998, pp 1437-1440.

33. Newton JM, Halsted CH. Dietary and nutritional assessment. In: Shils M, Olson JA, Shike M. Modern Nutrition in Health and Disease, 9th ed. Philadelphia: Lea & Febiger Co,  1998:895-902.

34. Halsted CH. Role of nutrition in the treatment of alcoholic liver disease. In Arroyo V, Bosch J, Bruguera M, Rodes J, Tapias JMS eds. Treatment of Liver Diseases. Barcelona, Masson,1999; 221-231.

35.  Halsted CH. Evaluating Malnutrition: What should the physician look for? In Gershwin ME, German JB, Keen CL. Nutrition and Immunology Principles and Practice. New York Humana Press, 1999; 15-20.

36. Halsted CH and Go VLW. Nutrition and gastrointestinal diseases. In Korenman S and Heber D Eds. Atlas of Clinical Endocrinology vol 5, Human Nutrition and Obesity. Philadelphia. Current Medicine, Inc. Philadelphia, 2000, pp 149-165.

37. Halsted CH. Malnutrition and nutritional assessment. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson L. Harrisons Principles of Internal Medicine, 15th ed. New York, McGraw-Hill Co. 2001, pp 455-461.

38. Halsted CH and Lönnerdal BL. Vitamin and Mineral Absorption. In: Yamada T. Textbook of Gastroenterology, 4th Edition. 2003; pp 449-471..

39. Halsted CH. Alcohol: Metabolism, Risks, Benefits, Toxicities. In: Caballero B, Trugo L and Finglas P, eds. Encyclopedia of Food Sciences and Nutrition. Academic Press, London, U.K. In Press, 2003.

40. Halsted CH. Malnutrition and nutritional assessment. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson L. Harrisons Principles of Internal Medicine, 16th ed. New York, McGraw-Hill Co. In Press,2003

Villanueva JA, Halsted CH. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 2004; 39: 1303-1310

Esfandiari F, Villanueva JA., Wong D, French SW, Halsted CH. Chronic Ethanol Feeding and Folate Deficiency Activate Hepatic Endoplasmic Reticulum Stress Pathway in Micropigs. American Journal of Physiology; Gastrointestinal and Liver Physiology. 2005; 289: G54-G63.

Villanueva JA, Esfandiari F, Wong DH, Ahmad I, Melnyk S, James SJ, Halsted CH. Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease. 2006; Alcoholism: Clinical and Experimental Research, 30: 1262-1270

Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH. Interactions among polymorphisms in folate metabolizing genes and serum total homocysteine in a healthy elderly population. Amer J Clin Nutr 2006;83:708-713

Halsted CH, Wong DH, Peerson JM, Warden CH, Refsum H, Smith AD, Nygard OK, Ueland PM, Vollset SE, Tell GS. Relationships of Glutamate Carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine levels and cognition in a homogenous Norwegian population: The Hordoland Homocysteine Study. Amer J Clin Nutr 2007;86:514-21.

Shafizadeh TB, Halsted CH Gamma-Glutamyl Hydrolase, not Glutamate Carboxypeptidase II, Hydrolyzes Dietary Folate in Rat Small Intestine J. Nutr. 2007; 137:1149-1153

Esfandiari F, Villanueva JA, Wong DH, You,M, French SW, Halsted CH. S-adenosylmethionine (SAM) attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate deficient diet. Alcoholism: Clinical and Experimental Research 2007. 31:1231-1239

Villanueva JA, Esfandiari F, White ME, Devaraj S, French SW, Halsted CH. S-adenosylmethionine (SAM) attenuates oxidative liver injury in micropigs fed ethanol with a folate deficient diet. Alcoholism: Clinical and Experimental Research 2007 In Press.


BOOKS

1. Halsted CH, Halsted JA, eds. The laboratory in clinical medicine. 2nd ed. Philadelphia: WB Saunders, 1981.

2. Halsted CH, Rucker RB, eds. Nutrition and the origins of disease. San Diego: Academic Press, 1989.

 

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